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    Devices, methods and systems for collecting material from a breast duct
    1.
    发明授权
    Devices, methods and systems for collecting material from a breast duct 有权
    用于从乳房管收集材料的装置，方法和系统

    公开(公告)号：US06413228B1

    公开(公告)日：2002-07-02

    申请号：US09473510

    申请日：1999-12-28

    申请人： David Hung ,  Christopher G. M. Ken ,  Xuanmin He ,  Phillip M. Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    发明人： David Hung ,  Christopher G. M. Ken ,  Xuanmin He ,  Phillip M. Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    IPC分类号： A61B1000

    CPC分类号： A61M3/0279 ,  A61B10/0041 ,  A61B10/0045 ,  A61M3/0262 ,  A61M2210/1007 ,  G01N33/57415

    摘要： The invention provides methods, devices and systems for collecting breast ductal fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductal access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for indentification of breast precancer or cancer in patient.

    摘要翻译： 本发明提供了用于收集乳腺导管液的方法，装置和系统，包括细胞材料和用于分析的其它有用标记物。 所述方法通常包括进入至少一个乳房导管并从该管道收集与乳房中所有其他导管分开的材料。 这些装置包括导管进入装置，其提供从与乳房中的所有其他导管分开的单个管道收集流体的机会。 系统采用一起使用的方法和装置，其提供用于分析特定于被访问的乳房导管的患者的乳房状况的系统。 方法，装置和系统对于患者中乳腺癌前病变或癌症的鉴别特别有用。

    Devices, methods and systems for collecting material from a breast duct
    2.
    发明申请
    Devices, methods and systems for collecting material from a breast duct 审中-公开
    用于从乳房管收集材料的装置，方法和系统

    公开(公告)号：US20070270708A1

    公开(公告)日：2007-11-22

    申请号：US11880811

    申请日：2007-07-24

    申请人： David Hung ,  Christopher Ken ,  Xuanmin He ,  Phillip Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    发明人： David Hung ,  Christopher Ken ,  Xuanmin He ,  Phillip Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    IPC分类号： A61B10/02

    CPC分类号： A61B10/02 ,  A61B10/0041 ,  A61B10/0045 ,  A61B10/0283

    摘要： The invention provides methods, devices and systems for collecting breast ductal fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductal access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for indentification of breast precancer or cancer in patient.

    摘要翻译： 本发明提供了用于收集乳腺导管液的方法，装置和系统，包括细胞材料和用于分析的其它有用标记物。 所述方法通常包括进入至少一个乳房导管并从该管道收集与乳房中所有其他导管分开的材料。 这些装置包括导管进入装置，其提供从与乳房中的所有其他导管分开的单个管道收集流体的机会。 系统采用一起使用的方法和装置，其提供用于分析特定于被访问的乳房导管的患者的乳房状况的系统。 方法，装置和系统对于患者中乳腺癌前病变或癌症的鉴别特别有用。

    Methods and systems for treating breast tissue
    4.
    发明授权
    Methods and systems for treating breast tissue 有权
    用于治疗乳腺组织的方法和系统

    公开(公告)号：US06712816B2

    公开(公告)日：2004-03-30

    申请号：US10144853

    申请日：2002-05-15

    申请人： David Hung ,  Chris Ken ,  Julian Nikolchev ,  Susan Love ,  Shawn O'Leary

    发明人： David Hung ,  Chris Ken ,  Julian Nikolchev ,  Susan Love ,  Shawn O'Leary

    IPC分类号： A61B1818

    CPC分类号： A61B18/00 ,  A61B18/02 ,  A61B18/1485 ,  A61B2018/0212 ,  A61N5/0601 ,  A61N5/062

    摘要： Methods, systems, and kits for treating breast tissue rely on transferring energy to or from cells lining an individual breast duct. Energy can be introduced into the breast duct, e.g., by filling the duct with an electrically conductive medium and applying radiofrequency energy to the medium. Other energy forms could also be used, such as light, ultrasound, radiation, microwave energy, heat, cold, direct current, and the like. By treating individual breast ducts, cancerous and pre-cancerous conditions originating in the duct can be effectively treated.

    摘要翻译： 用于治疗乳腺组织的方法，系统和试剂盒依赖于将能量转移到单独的乳房导管衬里的细胞或从细胞内移出能量。 可以将能量引入到乳房管道中，例如通过用导电介质填充管道并且向介质施加射频能量。 也可以使用其他能量形式，例如光，超声，辐射，微波能量，热，冷，直流电等。 通过治疗个体乳腺导管，可以有效地治疗起源于管道的癌性和癌前病症。

    Methods using pressure to obtain fluids and cellular material from breast ducts
    5.
    发明授权
    Methods using pressure to obtain fluids and cellular material from breast ducts 有权
    使用压力从乳房导管获得流体和细胞材料的方法

    公开(公告)号：US06494859B2

    公开(公告)日：2002-12-17

    申请号：US09301058

    申请日：1999-04-28

    申请人： Susan M. Love ,  David Hung ,  Xuanmin He

    发明人： Susan M. Love ,  David Hung ,  Xuanmin He

    IPC分类号： A61M100

    CPC分类号： A61B10/0045

    摘要： Methods, kits, and apparatus for obtaining cellular, chemical, and other materials from breast ducts are described. A single milk duct is accessed and washed with a washing fluid to obtain marker materials from the lining the duct. The washing fluid is then collected, and the marker materials in the washing fluid identified and analyzed. Usually, the washing fluid is introduced using a syringe through a lumen of a dual-lumen catheter. The ductal volume is filled with the washing fluid and excess fluid flows outwardly through a second lumen of the dual-lumen catheter, from which it is collected. Methods and kits provide for collection of fluid and cells by a lavage procedure that includes applying external pressure to the breast to improve the yield of fluid and cells from the breast duct.

    摘要翻译： 描述了从乳房导管获得细胞，化学和其他材料的方法，试剂盒和装置。 单个牛奶管被接入并用洗涤液洗涤，以从管道衬里获得标记材料。 然后收集洗涤液，并鉴定和分析洗涤液中的标记物质。 通常，使用注射器通过双腔导管的内腔引入洗涤液。 导管体积填充有洗涤液，过量的流体向外流过双腔导管的第二腔，从其收集。 方法和试剂盒通过灌洗程序提供流体和细胞的收集，其包括向乳房施加外部压力以提高流体和来自乳房导管的细胞的产量。