公开(公告)号：US09170706B2

公开(公告)日：2015-10-27

申请号：US13106732

申请日：2011-05-12

Applicant: Matthew Robert Scott ,  Tzuwei Shih ,  Yaping Liu

Inventor： Matthew Robert Scott ,  Tzuwei Shih ,  Yaping Liu

IPC: G06F3/048 ,  G06F3/0481 ,  G06F17/30 ,  G06F9/44

CPC classification number: G06F3/0481 ,  G06F9/453 ,  G06F17/30967

Abstract: Tools and techniques for a polymorphic query box operating on a computing device are described herein. The polymorphic query box application provides an adaptive query box via a single graphical user interface that detects an input scenario based on the type of input received via the polymorphic query box. In accordance with the detected scenario, the polymorphic query box dynamically changes appearance and function. In some implementations, the techniques include the polymorphic application ordering web search and/or translation based on the input being received. In some implementations, the techniques include providing context sensitive controls for input editing before completing the query.

Abstract translation: 本文描述了在计算设备上操作的多态查询框的工具和技术。 多态查询框应用程序通过单个图形用户界面提供自适应查询框，该界面根据通过多态查询框接收的输入类型来检测输入场景。 根据检测到的情况，多态查询框动态地改变外观和功能。 在一些实现中，这些技术包括基于所接收的输入的多态应用排序网页搜索和/或翻译。 在一些实现中，这些技术包括在完成查询之前提供用于输入编辑的上下文敏感控件。

公开(公告)号：US20120283284A1

公开(公告)日：2012-11-08

申请号：US13508277

申请日：2010-11-04

Applicant: Xiaodong Luo ,  Tao Feng ,  Yan Li ,  Yuanyuan Wang ,  Xianghai Cai ,  Yaping Liu

Inventor： Xiaodong Luo ,  Tao Feng ,  Yan Li ,  Yuanyuan Wang ,  Xianghai Cai ,  Yaping Liu

IPC: C07D519/00 ,  A61P35/00 ,  A61P35/02 ,  A61K31/4375

CPC classification number: C07D519/04 ,  A61K31/4375 ,  A61K31/475 ,  A61K36/24 ,  C07D519/00

Abstract: The present invention relates to pharmaceutical technical field, to melonine bisindole compounds, pharmaceutical compositions thereof, and preparation methods thereof. Specifically, the present invention relates to melonine bisindole compounds of Formula I, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts thereof. The present invention further relates to method for preparing the melonine bisindole compounds of Formula I or pharmaceutically acceptable salts thereof, and the use of the melonine bisindole compounds of Formula I or pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of cancers.

Abstract translation: 本发明涉及药用技术领域，甜瓜双吲哚化合物及其药物组合物及其制备方法。 具体地，本发明涉及式I的甜瓜双吲哚化合物，其药学上可接受的盐，包含该化合物或其药学上可接受的盐的药物组合物。 本发明还涉及制备式I的甜菜双吲哚化合物或其药学上可接受的盐的方法，以及式I的甜瓜双吲哚化合物或其药学上可接受的盐在制备用于治疗或预防 癌症

公开(公告)号：US20120278309A1

公开(公告)日：2012-11-01

申请号：US13331942

申请日：2011-12-20

Applicant: QUAN TANG ,  KUN JING ,  YAPING LIU ,  WINNY K. SO ,  MENGTONG YANG ,  PENGYANG XU

Inventor： QUAN TANG ,  KUN JING ,  YAPING LIU ,  WINNY K. SO ,  MENGTONG YANG ,  PENGYANG XU

IPC: G06F17/30

CPC classification number: G06F17/30864 ,  G06F17/30867

Abstract: Systems, methods, and computer media for providing alternative market search results are provided. A user search query in a first market is received. Search results relevant to the user search query are identified for the first market in a first language. A user intent to receive search results for the user search query for a second market and in a second language is determined. A search results page is presented that includes headings and search results for the first market in the first language as well as a search result toggle that includes a user-selectable option to present alternative search results for a second market in a second language. Selection of the option to present alternative search results causes search results for the second market and in the second language to be presented in the search results page along with the search results page headings in the first language.

Abstract translation: 提供了用于提供替代市场搜索结果的系统，方法和计算机媒体。 接收到第一市场中的用户搜索查询。 搜索与用户搜索查询相关的搜索结果以第一语言识别第一市场。 确定用于接收用于第二市场和第二语言的用户搜索查询的搜索结果的用户。 提供搜索结果页面，其中包括第一语言的第一个市场的标题和搜索结果，以及搜索结果切换，其包括用户可选择的选项来呈现第二语言的第二市场的替代搜索结果。 选择提供替代搜索结果的选项会导致第二个市场和第二种语言的搜索结果与搜索结果页面标题中的第一语言一起显示在搜索结果页面中。

公开(公告)号：US20070124947A1

公开(公告)日：2007-06-07

申请号：US11585931

申请日：2006-10-25

Applicant: Jay Munroe ,  Haizhang Li ,  Yaping Liu

Inventor： Jay Munroe ,  Haizhang Li ,  Yaping Liu

IPC: G01C15/00

CPC classification number: G01C15/004 ,  G02B3/02 ,  Y10S33/21

Abstract: A non-cylindrically surfaced lens converts a collimated light beam into a light plane that increases a light intensity toward distal portions of the light plane's arc so as to substantially uniformly project a reference light line onto a reference surface onto which the light plane is projected. The non-cylindrically surfaced lens has first and second surfaces that remain constant over at least a portion of the z direction length of the lens. The second surface defines a multiple-radius curve in an x,y plane. The lens may be incorporated into a self-leveled optical device that projects a reference light line onto a reference surface at a predetermined angle relative to horizontal.

Abstract translation: 非圆柱形表面的透镜将准直光束转换成光平面，该光平面朝向光平面弧的远端部分增加光强度，从而基本上均匀地将参考光线投影到光平面投射到的参考表面上。 非圆柱形表面的透镜具有在透镜的z方向长度的至少一部分上保持恒定的第一和第二表面。 第二表面在x，y平面中限定多重半径曲线。 透镜可以结合到自平层光学装置中，该装置将参考光线相对于水平面以预定角度投影到参考表面上。

公开(公告)号：US08788591B2

公开(公告)日：2014-07-22

申请号：US10794411

申请日：2004-03-04

Applicant: Jianguo Jiang ,  Yaping Liu ,  Jingwei Liang ,  Wei Huang ,  Shijun Wu

Inventor： Jianguo Jiang ,  Yaping Liu ,  Jingwei Liang ,  Wei Huang ,  Shijun Wu

IPC: G06F15/16

CPC classification number: H04L51/26 ,  G06F9/546 ,  H04L47/2441 ,  H04L47/50 ,  H04L47/521 ,  H04L47/6215 ,  H04L49/90 ,  H04L49/9036 ,  H04L51/14 ,  H04L51/30

Abstract: Messages are received and retained in memory and are batch processed including transferring the messages to a cell pool having cells of predetermined size. The location and size of the messages are recorded in a table map with other pertinent information as is required. Messages in the cell pool are processed and delivered asynchronously.

Abstract translation: 消息被接收并保留在存储器中并被批处理，包括将消息传送到具有预定大小的小区的小区池。 消息的位置和大小记录在表格映射中，并且需要其他相关信息。 单元池中的消息将被异步处理和传送。

公开(公告)号：US08595208B2

公开(公告)日：2013-11-26

申请号：US13355195

申请日：2012-01-20

Applicant: Kun Jing ,  Matthew Robert Scott ,  Kaihua Yin ,  Ye Xu ,  Yaping Liu ,  Quan Tang ,  Hao Wei

Inventor： Kun Jing ,  Matthew Robert Scott ,  Kaihua Yin ,  Ye Xu ,  Yaping Liu ,  Quan Tang ,  Hao Wei

IPC: G06F17/30

CPC classification number: G06F17/30864 ,  G06F17/30905

Abstract: Systems, methods, and computer-readable media for presenting video as at least a portion of the background of search engine home pages are provided. Upon receiving a request for presentation of a search engine home page, a static image is transmitted for presentation as at least a portion of the background for the search engine home page. Also transmitted is a streaming video file. The static image may or may not be associated with the streaming video file. After a predetermined amount of time, play of the streaming video file is initiated without user action, the streaming video file replacing the static image as at least a portion of the background of the search engine home page. In this way, the user receives a seamless transition from a static image to a video presentation and is provided a rich, immersive experience at the search engine home page.

Abstract translation: 提供了用于呈现作为搜索引擎主页背景的至少一部分的视频的系统，方法和计算机可读介质。 在接收到呈现搜索引擎主页的请求时，发送用于呈现的静态图像作为用于搜索引擎主页的背景的至少一部分。 还传输了一个流式视频文件。 静态图像可以是也可以不与流式视频文件相关联。 在预定量的时间之后，无需用户动作即可启动流式视频文件的播放，流媒体视频文件将静态图像替换为搜索引擎主页背景的至少一部分。 以这种方式，用户从静态图像到视频呈现的无缝转换，并在搜索引擎主页上提供丰富的沉浸式体验。

公开(公告)号：US20120323878A1

公开(公告)日：2012-12-20

申请号：US13355195

申请日：2012-01-20

Applicant: KUN JING ,  MATTHEW ROBERT SCOTT ,  KAIHUA YIN ,  YE XU ,  YAPING LIU ,  QUAN TANG ,  HAO WEI

Inventor： KUN JING ,  MATTHEW ROBERT SCOTT ,  KAIHUA YIN ,  YE XU ,  YAPING LIU ,  QUAN TANG ,  HAO WEI

IPC: G06F17/30

CPC classification number: G06F17/30864 ,  G06F17/30905

Abstract: Systems, methods, and computer-readable media for presenting video as at least a portion of the background of search engine home pages are provided. Upon receiving a request for presentation of a search engine home page, a static image is transmitted for presentation as at least a portion of the background for the search engine home page. Also transmitted is a streaming video file. The static image may or may not be associated with the streaming video file. After a predetermined amount of time, play of the streaming video file is initiated without user action, the streaming video file replacing the static image as at least a portion of the background of the search engine home page. In this way, the user receives a seamless transition from a static image to a video presentation and is provided a rich, immersive experience at the search engine home page.

Abstract translation: 提供了用于呈现作为搜索引擎主页背景的至少一部分的视频的系统，方法和计算机可读介质。 在接收到呈现搜索引擎主页的请求时，发送用于呈现的静态图像作为用于搜索引擎主页的背景的至少一部分。 还传输了一个流式视频文件。 静态图像可以是也可以不与流式视频文件相关联。 在预定量的时间之后，无需用户动作即可启动流式视频文件的播放，流媒体视频文件将静态图像替换为搜索引擎主页背景的至少一部分。 以这种方式，用户从静态图像到视频呈现的无缝转换，并在搜索引擎主页上提供丰富的沉浸式体验。

公开(公告)号：US20220034902A1

公开(公告)日：2022-02-03

申请号：US17299559

申请日：2019-12-06

Applicant: Eberhard DURR ,  Yaping LIU ,  Zhifeng CHEN ,  Arthur FRIDMAN ,  Merck Sharp & Dohme Corp.

Inventor： Eberhard Durr ,  Yaping Liu ,  Zhifeng Chen ,  Arthur Fridman

IPC: G01N33/68 ,  C07K16/12

Abstract: A method is described for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of antibody producing cell libraries such as B-cell and hybridoma libraries. Specifically, the method relates to application of reversed immunocapture and high resolution tandem mass spectrometry for the identification of heavy and light chain pairs of binding antibodies obtained from high throughput screens of antibody producing cell libraries.

公开(公告)号：US20190177792A1

公开(公告)日：2019-06-13

申请号：US16323158

申请日：2017-08-04

Applicant: Yaping LIU ,  Manolis KELLIS ,  Viktor ADALSTEINSSON ,  Zhizhuo ZHANG ,  THE BROAD INSTITUTE, INC. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： YAPING LIU ,  MANOLIS KELLIS ,  VIKTOR ADALSTEINSSON ,  ZHIZHUO ZHANG

IPC: C12Q1/6874 ,  G16B20/20 ,  G16B30/00 ,  C12N15/10

Abstract: As described below, disclosed herein are methods of analyzing DNA methylation in cell-free DNA (cfDNA) and genomic DNA (gDNA) from sequencing data.

公开(公告)号：US20120290967A1

公开(公告)日：2012-11-15

申请号：US13106732

申请日：2011-05-12

Applicant: Matthew Robert Scott ,  Tzuwei Shih ,  Yaping Liu

Inventor： Matthew Robert Scott ,  Tzuwei Shih ,  Yaping Liu

IPC: G06F3/048

CPC classification number: G06F3/0481 ,  G06F9/453 ,  G06F17/30967

Abstract: Tools and techniques for a polymorphic query box operating on a computing device are described herein. The polymorphic query box application provides an adaptive query box via a single graphical user interface that detects an input scenario based on the type of input received via the polymorphic query box. In accordance with the detected scenario, the polymorphic query box dynamically changes appearance and function. In some implementations, the techniques include the polymorphic application ordering web search and/or translation based on the input being received. In some implementations, the techniques include providing context sensitive controls for input editing before completing the query.

Abstract translation: 本文描述了在计算设备上操作的多态查询框的工具和技术。 多态查询框应用程序通过单个图形用户界面提供自适应查询框，该界面根据通过多态查询框接收的输入类型来检测输入场景。 根据检测到的情况，多态查询框动态地改变外观和功能。 在一些实现中，这些技术包括基于所接收的输入的多态应用排序网页搜索和/或翻译。 在一些实现中，这些技术包括在完成查询之前提供用于输入编辑的上下文敏感控件。