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    APOPTOSIS-INDUCING AGENT FOR PROSTATE CANCER CELLS
    2.
    发明申请
    APOPTOSIS-INDUCING AGENT FOR PROSTATE CANCER CELLS 有权
    用于前列腺癌细胞的病毒诱导剂

    公开(公告)号：US20110166545A1

    公开(公告)日：2011-07-07

    申请号：US13006198

    申请日：2011-01-13

    申请人： Hiromi KUMON ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu

    发明人： Hiromi KUMON ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu

    IPC分类号： A61M37/00 ,  A61K38/17 ,  A61K31/7088 ,  A61P35/00 ,  A61P35/04 ,  C12N15/85

    CPC分类号： C07K14/4747 ,  A61K38/00

    摘要： According to the present invention, an apoptosis-inducing agent for prostate cancer comprising REIC/Dkk-3 DNA or an REIC/Dkk-3 protein, and a therapeutic agent for prostate cancer and an agent for inhibiting prostate cancer metastasis that comprise such apoptosis-inducing agent are provided.An apoptosis-inducing agent for prostate cancer, comprising, as an active ingredient, an REIC/Dkk-3 protein (a) or (b) or REIC/Dkk-3 DNA (c) or (d): (a) a protein consisting of the amino acid sequence represented by SEQ ID NO: 2; (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by substitution or deletion of 1 or more amino acids; (c) DNA consisting of the nucleotide sequence represented by SEQ ID NO: 1; or (d) DNA that hybridizes under stringent conditions to DNA consisting of a nucleotide sequence complementary to the nucleotide sequence represented by SEQ ID NO: 1 and encodes a protein having apoptosis activity; and a therapeutic agent for prostate cancer comprising such apoptosis-inducing agent are provided

    摘要翻译： 根据本发明，包含REIC / Dkk-3 DNA或REIC / Dkk-3蛋白的前列腺癌细胞凋亡诱导剂，前列腺癌治疗剂和抑制前列腺癌转移的药剂， 提供诱导剂。 一种用于前列腺癌的凋亡诱导剂，其包含REIC / Dkk-3蛋白（a）或（b）或REIC / Dkk-3 DNA（c）或（d）作为活性成分：（a）蛋白质 由SEQ ID NO：2表示的氨基酸序列组成; （b）通过取代或缺失1个或多个氨基酸由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的蛋白质; （c）由SEQ ID NO：1表示的核苷酸序列组成的DNA; 或（d）在严格条件下与由与SEQ ID NO：1所示的核苷酸序列互补的核苷酸序列组成的DNA杂交的DNA，并编码具有凋亡活性的蛋白质; 并提供包含这种凋亡诱导剂的前列腺癌治疗剂

    Partial Fragment of REIC/Dkk-3 Gene and Cancer Therapeutic Agent Comprising the Same
    3.
    发明申请
    Partial Fragment of REIC/Dkk-3 Gene and Cancer Therapeutic Agent Comprising the Same 有权
    REIC / Dkk-3基因的部分片段和包含其的癌症治疗剂

    公开(公告)号：US20130274199A1

    公开(公告)日：2013-10-17

    申请号：US13925041

    申请日：2013-06-24

    申请人： HIROMI KUMON ,  NAM-HO HUH ,  MASAKIYO SAKAGUCHI ,  YASUTOMO NASU ,  FERNANDO GUILLERMO ABARZUA CABEZAS

    发明人： HIROMI KUMON ,  NAM-HO HUH ,  MASAKIYO SAKAGUCHI ,  YASUTOMO NASU ,  FERNANDO GUILLERMO ABARZUA CABEZAS

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4747

    摘要： This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.

    摘要翻译： 本发明提供了包含REIC / Dkk-3基因的片段的癌细胞中的凋亡诱导剂和包含其的癌症治疗剂。 本发明还提供编码具有凋亡活性的多肽的编码REIC / Dkk-3蛋白（a）或（b）的多核苷酸片段：（a）编码包含氨基酸1的氨基酸序列的多肽的多核苷酸至任何 的如SEQ ID NO：2所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸39至78; 或（b）编码多肽的多核苷酸，其包含衍生自SEQ ID NO：1所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸1至氨基酸39至78的氨基酸序列的氨基酸序列的氨基酸序列 NO：2通过取代，缺失或添加1个或几个氨基酸并具有凋亡活性。

    Therapeutic Agent for Malignant Mesothelioma and Immunostimulant
    4.
    发明申请
    Therapeutic Agent for Malignant Mesothelioma and Immunostimulant 有权
    恶性间皮瘤和免疫刺激剂的治疗剂

    公开(公告)号：US20110189237A1

    公开(公告)日：2011-08-04

    申请号：US13056443

    申请日：2009-07-30

    申请人： Hiromi Kumon ,  Yasutomo Nasu ,  Yuji Kashiwakura ,  Masami Watanabe ,  Nam-ho Huh ,  Masakiyo Sakaguchi

    发明人： Hiromi Kumon ,  Yasutomo Nasu ,  Yuji Kashiwakura ,  Masami Watanabe ,  Nam-ho Huh ,  Masakiyo Sakaguchi

    IPC分类号： A61K31/7088 ,  A61P35/00 ,  A61P37/04

    CPC分类号： C07K14/47 ,  A61K35/13 ,  A61K38/00 ,  C12N2799/022

    摘要： According to the present invention, a method for treating malignant mesothelioma using REIC/Dkk-3 and a therapeutic agent for malignant mesothelioma comprising REIC/Dkk-3 are provided. A mesothelioma therapeutic agent is provided, comprising the following REIC/Dkk-3 DNA or a vector comprising the DNA as an active ingredient: (a) a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1; or (b) a DNA hybridizing under stringent conditions to a DNA consisting of a nucleotide sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1 and encoding a protein having apoptosis-inducing activity and IL-7 production-accelerating activity in cells.

    摘要翻译： 根据本发明，提供了使用REIC / Dkk-3治疗恶性间皮瘤的方法和包含REIC / Dkk-3的恶性间皮瘤治疗剂。 提供间皮瘤治疗剂，其包含以下REIC / Dkk-3 DNA或包含该DNA作为活性成分的载体：（a）由SEQ ID NO：1所示核苷酸序列组成的DNA; 或（b）在严格条件下与由与SEQ ID NO：1所示核苷酸序列互补的核苷酸序列组成的DNA杂交并编码细胞中具有凋亡诱导活性和IL-7生产加速活性的蛋白质的DNA。

    Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same
    5.
    发明申请
    Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same 有权
    REIC / Dkk-3基因的部分片段和包含其的癌症治疗剂

    公开(公告)号：US20100173404A1

    公开(公告)日：2010-07-08

    申请号：US12447044

    申请日：2007-10-24

    申请人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu ,  Fernando Guillermo Abarzua Cabezas

    发明人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu ,  Fernando Guillermo Abarzua Cabezas

    IPC分类号： C07K14/435 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K16/18 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4747

    摘要： This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.

    摘要翻译： 本发明提供了包含REIC / Dkk-3基因的片段的癌细胞中的凋亡诱导剂和包含其的癌症治疗剂。 本发明还提供编码具有凋亡活性的多肽的编码REIC / Dkk-3蛋白（a）或（b）的多核苷酸片段：（a）编码包含氨基酸1的氨基酸序列的多肽的多核苷酸至任何 的如SEQ ID NO：2所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸39至78; 或（b）编码多肽的多核苷酸，其包含衍生自SEQ ID NO：1所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸1至氨基酸39至78的氨基酸序列的氨基酸序列的氨基酸序列 NO：2通过取代，缺失或添加1个或几个氨基酸并具有凋亡活性。

    Apoptosis-Inducing Agent for Prostate Cancer Cells
    6.
    发明申请
    Apoptosis-Inducing Agent for Prostate Cancer Cells 审中-公开
    前列腺癌细胞凋亡诱导剂

    公开(公告)号：US20090005538A1

    公开(公告)日：2009-01-01

    申请号：US11886338

    申请日：2006-01-10

    申请人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu

    发明人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu

    IPC分类号： C07K14/00

    CPC分类号： C07K14/4747 ,  A61K38/00

    摘要： According to the present invention, an apoptosis-inducing agent for prostate cancer comprising REIC/Dkk-3 DNA or an REIC/Dkk-3 protein, and a therapeutic agent for prostate cancer and an agent for inhibiting prostate cancer metastasis that comprise such apoptosis-inducing agent are provided.An apoptosis-inducing agent for prostate cancer, comprising, as an active ingredient, an REIC/Dkk-3 protein (a) or (b) or REIC/Dkk-3 DNA (c) or (d): (a) a protein consisting of the amino acid sequence represented by SEQ ID NO: 2; (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by substitution or deletion of 1 or more amino acids; (c) DNA consisting of the nucleotide sequence represented by SEQ ID NO: 1; or (d) DNA that hybridizes under stringent conditions to DNA consisting of a nucleotide sequence complementary to the nucleotide sequence represented by SEQ ID NO: 1 and encodes a protein having apoptosis activity; and a therapeutic agent for prostate cancer comprising such apoptosis-inducing agent are provided

    摘要翻译： 根据本发明，包含REIC / Dkk-3 DNA或REIC / Dkk-3蛋白的前列腺癌细胞凋亡诱导剂，前列腺癌治疗剂和抑制前列腺癌转移的药剂， 提供诱导剂。 一种用于前列腺癌的凋亡诱导剂，其包含REIC / Dkk-3蛋白（a）或（b）或REIC / Dkk-3 DNA（c）或（d）作为活性成分：（a）蛋白质 由SEQ ID NO：2表示的氨基酸序列组成; （b）通过取代或缺失1个或多个氨基酸由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的蛋白质; （c）由SEQ ID NO：1表示的核苷酸序列组成的DNA; 或（d）在严格条件下与由与SEQ ID NO：1所示的核苷酸序列互补的核苷酸序列组成的DNA杂交的DNA，并编码具有凋亡活性的蛋白质; 并提供包含这种凋亡诱导剂的前列腺癌治疗剂

    Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same
    7.
    发明授权
    Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same 有权
    REIC / Dkk-3基因的部分片段和包含其的癌症治疗剂

    公开(公告)号：US08618273B2

    公开(公告)日：2013-12-31

    申请号：US12447044

    申请日：2007-10-24

    申请人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu ,  Fernando Guillermo Abarzua Cabezas

    发明人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu ,  Fernando Guillermo Abarzua Cabezas

    IPC分类号： C07H21/02 ,  C07H21/04

    CPC分类号： C07K16/18 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4747

    摘要： This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.

    摘要翻译： 本发明提供了包含REIC / Dkk-3基因的片段的癌细胞中的凋亡诱导剂和包含其的癌症治疗剂。 本发明还提供编码具有凋亡活性的多肽的编码REIC / Dkk-3蛋白（a）或（b）的多核苷酸片段：（a）编码包含氨基酸1的氨基酸序列的多肽的多核苷酸至任何 的如SEQ ID NO：2所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸39至78; 或（b）编码多肽的多核苷酸，其包含衍生自SEQ ID NO：1所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸1至氨基酸39至78的氨基酸序列的氨基酸序列的氨基酸序列 NO：2通过取代，缺失或添加1个或几个氨基酸并具有凋亡活性。

    Direct administration of REIC/Dkk-3 to mesothelioma
    10.
    发明授权
    Direct administration of REIC/Dkk-3 to mesothelioma 有权
    将REIC / Dkk-3直接给予间皮瘤

    公开(公告)号：US09475865B2

    公开(公告)日：2016-10-25

    申请号：US13925041

    申请日：2013-06-24

    申请人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu ,  Fernando Guillermo Abarzua Cabezas

    发明人： Hiromi Kumon ,  Nam-ho Huh ,  Masakiyo Sakaguchi ,  Yasutomo Nasu ,  Fernando Guillermo Abarzua Cabezas

    IPC分类号： A61K48/00 ,  C12N15/85 ,  C07K16/18 ,  A61K31/711 ,  C07K14/47 ,  A61K38/00

    CPC分类号： C07K16/18 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4747

    摘要： This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.

    摘要翻译： 本发明提供了包含REIC / Dkk-3基因的片段的癌细胞中的凋亡诱导剂和包含其的癌症治疗剂。 本发明还提供编码具有凋亡活性的多肽的编码REIC / Dkk-3蛋白（a）或（b）的多核苷酸片段：（a）编码包含氨基酸1的氨基酸序列的多肽的多核苷酸至任何 的如SEQ ID NO：2所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸39至78; 或（b）编码多肽的多核苷酸，其包含衍生自SEQ ID NO：1所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸1至氨基酸39至78的氨基酸序列的氨基酸序列的氨基酸序列 NO：2通过取代，缺失或添加1个或几个氨基酸并具有凋亡活性。