公开(公告)号：US07705577B2

公开(公告)日：2010-04-27

申请号：US11755331

申请日：2007-05-30

申请人： Jian Li ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

发明人： Jian Li ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

IPC分类号： G05F1/00

CPC分类号： H02M3/157

摘要： A switched voltage regulator provides improved regulation at a lower clock rate/sampling frequency (e.g. several orders of magnitude lower than would be required for comparable regulation) while using a low resolution digital pulse width modulator such that limit cycle oscillations occur (and thus of low cost and complexity and small size) by limiting the amplitude of limit cycle oscillations which therefore need not be avoided by more complex arrangements which are not commercially feasible. Limiting of amplitude of limit cycle oscillations is achieved by adding essentially a digitized ripple voltage signal corresponding to the difference between the output of the voltage regulator and an average output of the voltage regulator as an input to the digital pulse width modulator. Performance of this arrangement may be enhanced by adding a ramp signal to the digitized ripple voltage signal and even further enhanced by limiting the ramp signal to a range which corresponds to steady state operation but not transients.

摘要翻译： 开关电压调节器在使用低分辨率数字脉冲宽度调制器时，以较低的时钟频率/采样频率（例如比可比较的调节要求的数量级低几个数量级）提供改进的调节器，从而发生极限循环振荡（从而降低 成本和复杂性以及小尺寸）通过限制极限循环振荡的幅度，因此不可避免地由于商业上不可行的更复杂的布置。 极限循环振荡幅度的限制通过将基本上相当于电压调节器的输出与调压器的平均输出之间的差值相对应的数字化纹波电压信号作为数字脉宽调制器的输入来实现。 可以通过向数字化纹波电压信号添加斜坡信号并且甚至通过将斜坡信号限制到对应于稳态操作但不是瞬变的范围来进一步增强该布置的性能。

公开(公告)号：US20100273661A1

公开(公告)日：2010-10-28

申请号：US12663311

申请日：2008-06-11

申请人： Yang Qiu ,  Dilip Rajagopalan ,  Lei Zhu ,  Susan C Connor ,  Guanghui Hu ,  David Maclean ,  Doris Damian ,  Amir Handzel ,  Rajalakshmi Balasubramanian

发明人： Yang Qiu ,  Dilip Rajagopalan ,  Lei Zhu ,  Susan C Connor ,  Guanghui Hu ,  David Maclean ,  Doris Damian ,  Amir Handzel ,  Rajalakshmi Balasubramanian

IPC分类号： G01N33/92 ,  G01N33/68 ,  G01N33/48 ,  C12Q1/37 ,  G01N33/66 ,  G01N33/72 ,  C40B30/00 ,  G06F19/00 ,  A61B5/00

CPC分类号： G01N33/6893 ,  G01N2333/54 ,  G01N2800/042 ,  G06Q50/24 ,  G16B40/00 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/201666 ,  Y10T436/203332

摘要： A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine. Also provided are kits useful for the methods of the invention.

摘要翻译： 提供了预测II型糖尿病患者对罗格列酮治疗反应的方法。 该方法涉及来自患有II型糖尿病的患者的至少一种样品，并分析预测将对罗格列酮治疗作出反应的患者的生物标志物。 生物标志物至少包括白细胞介素-8，组氨酸，柠檬酸盐。 这些生物标志物在至少一种选自基于多数投票的分类器和支持向量机（SVM）分类器的分类分析中被鉴定。 还提供了用于在开始治疗后8周预测II型糖尿病患者对格列本脲的治疗反应的方法。 该方法包括从已经用格列本脲治疗约4周的II型糖尿病患者获得样品，并分析预测在8周时对格列本脲治疗作出反应的患者的生物标志物。 在该方法中有用的生物标志物至少包括鞘磷脂23：1和L-苯丙氨酸。 还提供了可用于本发明方法的试剂盒。

公开(公告)号：US08245135B2

公开(公告)日：2012-08-14

申请号：US12555351

申请日：2009-09-08

申请人： Wei Jia Cai ,  Xiao Xiao Lian ,  Shixia Liu ,  Shimei Pan ,  Wei Hong Qian ,  Yang Qiu Song ,  Qiang Zhang ,  Michelle Xue Zhou

发明人： Wei Jia Cai ,  Xiao Xiao Lian ,  Shixia Liu ,  Shimei Pan ,  Wei Hong Qian ,  Yang Qiu Song ,  Qiang Zhang ,  Michelle Xue Zhou

IPC分类号： G06F17/00 ,  G06F17/30

CPC分类号： G06F17/30884

摘要： A method and system of producing a visual text summarization. According to the method, a plurality of topics may be extracted from a collection of text documents, where each of the topics comprises a distribution of topic keywords. An importance ranking for each of the topics may be determined, and an importance ranking for each of the topic keywords of a topic may also be determined. A graph may be displayed having a plurality of stacked layers representing a group of topics selected from the plurality of topics based on the importance ranking of the topics. A keyword cloud within each layer of the graph may also be displayed, where the one keyword cloud is a group of topic keywords selected from the extracted topic keywords based on the importance ranking of the extracted topic keywords.

摘要翻译： 一种生产视觉文本摘要的方法和系统。 根据该方法，可以从文本文档的集合中提取多个主题，其中每个主题包括主题关键词的分发。 可以确定每个主题的重要性排名，并且还可以确定主题中的每个主题关键字的重要性排名。 可以基于主题的重要性排序，显示具有代表从多个主题中选择的一组主题的多个堆叠层的图形。 还可以显示图中每一层内的关键字云，其中一个关键词云是基于所提取的主题关键词的重要性等级从所提取的主题关键词中选择的一组主题关键字。

公开(公告)号：US20110060983A1

公开(公告)日：2011-03-10

申请号：US12555351

申请日：2009-09-08

申请人： Wei Jia Cai ,  Xiao Xiao Lian ,  Shi Xia Liu ,  Shimei Pan ,  Wei Hong Qian ,  Yang Qiu Song ,  Qiang Q. Zhang ,  Michelle X. Zhou

发明人： Wei Jia Cai ,  Xiao Xiao Lian ,  Shi Xia Liu ,  Shimei Pan ,  Wei Hong Qian ,  Yang Qiu Song ,  Qiang Q. Zhang ,  Michelle X. Zhou

IPC分类号： G06F3/14

CPC分类号： G06F17/30884

摘要： A method and system of producing a visual text summarization. According to the method, a plurality of topics may be extracted from a collection of text documents, where each of the topics comprises a distribution of topic keywords. An importance ranking for each of the topics may be determined, and an importance ranking for each of the topic keywords of a topic may also be determined. A graph may be displayed having a plurality of stacked layers representing a group of topics selected from the plurality of topics based on the importance ranking of the topics. A keyword cloud within each layer of the graph may also be displayed, where the one keyword cloud is a group of topic keywords selected from the extracted topic keywords based on the importance ranking of the extracted topic keywords.

摘要翻译： 一种生产视觉文本摘要的方法和系统。 根据该方法，可以从文本文档的集合中提取多个主题，其中每个主题包括主题关键词的分发。 可以确定每个主题的重要性排名，并且还可以确定主题中的每个主题关键字的重要性排名。 可以基于主题的重要性排序，显示具有代表从多个主题中选择的一组主题的多个堆叠层的图形。 还可以显示图中每一层内的关键字云，其中一个关键词云是基于所提取的主题关键词的重要性等级从所提取的主题关键词中选择的一组主题关键字。

公开(公告)号：US07570037B2

公开(公告)日：2009-08-04

申请号：US11561104

申请日：2006-11-17

申请人： Jian Li ,  Dong S. Ha ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

发明人： Jian Li ,  Dong S. Ha ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

IPC分类号： G05F1/575 ,  G05F1/618

CPC分类号： H02M3/157

摘要： A digital pulse width modulator leverages clock frequency to achieve very fine duty cycle resolution by using a constant number of time slots for each state of a pulse signal and varying the number of time slots in a switching cycle within acceptable limits for variation of the switching cycle frequency or by using two relatively low frequency clocks of slightly differing frequency and selecting pulse leading and trailing edges in accordance with pulses output therefrom. A fine resolution of duty cycle adjustment can thus be provided corresponding to a much higher effective clock frequency than is actually used; allowing improvement of efficiency of clock and switching circuits, particularly in switching voltage regulator applications.

摘要翻译： 数字脉冲宽度调制器利用时钟频率通过对脉冲信号的每个状态使用恒定数量的时隙来实现非常精细的占空比分辨率，并且在开关周期内将开关周期中的时隙数量改变为可接受的开关周期变化的限度内 或通过使用两个稍微不同频率的相对低频的时钟，并根据从其输出的脉冲选择脉冲前沿和后沿。 因此，可以对应于比实际使用的更高的有效时钟频率提供精确的占空比调整分辨率; 允许提高时钟和开关电路的效率，特别是在开关稳压器应用中。

公开(公告)号：US20080298090A1

公开(公告)日：2008-12-04

申请号：US11755331

申请日：2007-05-30

申请人： Jian Li ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

发明人： Jian Li ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

IPC分类号： H02M3/335

CPC分类号： H02M3/157

摘要： A switched voltage regulator provides improved regulation at a lower clock rate/sampling frequency (e.g. several orders of magnitude lower than would be required for comparable regulation) while using a low resolution digital pulse width modulator such that limit cycle oscillations occur (and thus of low cost and complexity and small size) by limiting the amplitude of limit cycle oscillations which therefore need not be avoided by more complex arrangements which are not commercially feasible. Limiting of amplitude of limit cycle oscillations is achieved by adding essentially a digitized ripple voltage signal corresponding to the difference between the output of the voltage regulator and an average output of the voltage regulator as an input to the digital pulse width modulator. Performance of this arrangement may be enhanced by adding a ramp signal to the digitized ripple voltage signal and even further enhanced by limiting the ramp signal to a range which corresponds to steady state operation but not transients.

摘要翻译： 开关电压调节器在使用低分辨率数字脉冲宽度调制器时，以较低的时钟频率/采样频率（例如比可比较的调节要求的数量级低几个数量级）提供改进的调节器，从而发生极限循环振荡（从而降低 成本和复杂性以及小尺寸）通过限制极限循环振荡的幅度，因此不可避免地由于商业上不可行的更复杂的布置。 极限循环振荡幅度的限制通过将基本上相当于电压调节器的输出与调压器的平均输出之间的差值相对应的数字化纹波电压信号作为数字脉宽调制器的输入来实现。 可以通过向数字化纹波电压信号添加斜坡信号并且甚至通过将斜坡信号限制到对应于稳态操作但不是瞬变的范围来进一步增强该布置的性能。

公开(公告)号：US20080116871A1

公开(公告)日：2008-05-22

申请号：US11561104

申请日：2006-11-17

申请人： Jian Li ,  Dong S. Ha ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

发明人： Jian Li ,  Dong S. Ha ,  Yang Qiu ,  Ming Xu ,  Fred C. Lee

IPC分类号： G05F1/00

CPC分类号： H02M3/157

摘要： A digital pulse width modulator leverages clock frequency to achieve very fine duty cycle resolution by using a constant number of time slots for each state of a pulse signal and varying the number of time slots in a switching cycle within acceptable limits for variation of the switching cycle frequency or by using two relatively low frequency clocks of slightly differing frequency and selecting pulse leading and trailing edges in accordance with pulses output therefrom. A fine resolution of duty cycle adjustment can thus be provided corresponding to a much higher effective clock frequency than is actually used; allowing improvement of efficiency of clock and switching circuits, particularly in switching voltage regulator applications.

摘要翻译： 数字脉冲宽度调制器利用时钟频率通过对脉冲信号的每个状态使用恒定数量的时隙来实现非常精细的占空比分辨率，并且在开关周期内将开关周期中的时隙数量改变为可接受的开关周期变化的限度内 或通过使用两个稍微不同频率的相对低频的时钟，并根据从其输出的脉冲选择脉冲前沿和后沿。 因此，可以对应于比实际使用的更高的有效时钟频率提供精确的占空比调整分辨率; 允许提高时钟和开关电路的效率，特别是在开关稳压器应用中。