摘要:
A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine. Also provided are kits useful for the methods of the invention.
摘要:
A system clock signal generator circuit comprising a first PLL circuit that is frequency and phase locked to a wobble signal; a frequency and phase comparator for comprising a first output signal from the first PLL circuit with a system clock signal as frequency divided by M and for outputting a second output signal based on the differences in frequency and in phase; a PLL filter for providing a predetermined cutoff to the second output signal to output a third output signal; a pulse width modulating circuit for generating a pulse wave, the carrier frequency of which is a second reference clock signal, and for outputting a fourth output signal obtained by modulating the pulse width of the pulse wave by the third output signal; a low pass filter for smoothing the fourth output signal to output a fifth output signal; a VCO circuit the control voltage of which is the fifth output signal; a first frequency divider circuit for frequency dividing an output signal of the VCO circuit by N to output a system clock signal; and a second frequency divider circuit for frequency dividing, by M, and feeding the system clock signal back to the frequency and phase comparator.
摘要:
A switch pack assembly for cable clusters of network switches includes a central framework and two covers arranged movably at two sides of the central framework. Several longitudinal parallel holding troughs are arranged on the central framework. The main body of the cover covers the holding troughs to form cavities. Open windows are arranged at positions on the cover corresponding to the front parts of at least one pair of cavities. A longitudinal sliding guide component and a pulling resisting component are arranged on the outside of the switch pack assembly and are designed to interact with a release tool. A shape of a front end of the release tool matches a shape of the switch pack assembly. At the front end of the tool are arranged unlocking pressure plates to interact with snap latches of plugs in the open windows. At the inside of the tool are arranged a longitudinal sliding positioning mechanism to interact with the sliding guide component and a pulling force-applying mechanism to interact with the pulling resisting component. With these structures, the operation of plugging and pulling cables as a whole is convenient and quick.
摘要:
Motifs and patterns are generated by computer and printed on fabric, paper or plastic materials in continuous non-repeating patterns. The data is produced automatically by a random math algorithm, so that each of the printed patterns is similar, but not identical. The layout is arranged in a random manner, so that every part of the print is unique and exclusive. The size, color, motifs as well as the level of similarity or variety of the motifs and any other parameter essential to the design are all managed by the software.
摘要:
A waterproof camera sealing method includes steps of: the chamber body of the camera is provided with a charging valve installation hole, a camera lens, a circuit board, a data line and the chamber body of the camera are assembled as a waterproof camera semi-finished product; the charging valve is arranged inside the charging valve installation hole on the camera chamber body; the air is filled into the chamber body of the camera; the waterproof camera semi-finished product is poured into water; whether continuous bubbles burst out or not is observed so as to detect the sealing performance of the camera; the semi-finished product where bubbles continuously burst out is an unqualified product; the air inside the camera chamber body with qualified sealing performances is pumped out till the vacuum exists in the chamber body; the idler gas is filled into the chamber body of the camera; the charging valve installation hole is sealed by waterproof sealing glue; thus obtain the finished waterproof camera with sealing completed.
摘要:
A promoter comprising the isolated promoter region of the human Thymic Stromal Lymphopoietin (TSLP) gene and functional portions of the promoter region having TSLP promoter activity. The promoters are useful for identifying promoter agonists and antagonists that can be used to prevent or treat allergic conditions and autoimmune diseases.
摘要:
Mast cell-expressed membrane proteins that are highly expressed in human mast cells and the lungs as compared to brain, heart, kidney, liver, tracheal, and similar tissues. The proteins are transmembrane proteins involved in the regulation of mast cell and lung tissue function, including degranulation of mast cells. The preferred protein is a 187 amino acid transmembrane protein having an intercellular domain comprising amino acids 1 through 82, a transmembrane domain comprising amino acids 83 through 105, and an extracellular domain comprising amino acids 106 through 187 (SEQ ID NO:2).
摘要翻译:与大脑,心脏,肾脏,肝脏,气管和类似组织相比,肥大细胞表达的膜蛋白在人类肥大细胞和肺中高度表达。 蛋白质是涉及肥大细胞和肺组织功能调节的跨膜蛋白,包括肥大细胞的脱颗粒。 优选的蛋白质是187氨基酸跨膜蛋白,其具有包含氨基酸1至82的细胞间结构域,包含氨基酸83至105的跨膜结构域和包含氨基酸106至187(SEQ ID NO:2)的细胞外结构域。