公开(公告)号：US20130053574A1

公开(公告)日：2013-02-28

申请号：US13447632

申请日：2012-04-16

申请人： Wanbin Zhang ,  Delong Liu ,  Hui Guo ,  Yangang Liu

发明人： Wanbin Zhang ,  Delong Liu ,  Hui Guo ,  Yangang Liu

IPC分类号： C07C29/145 ,  C07C213/00 ,  C07D213/30 ,  C07C41/26

CPC分类号： C07C29/145 ,  C07B53/00 ,  C07B2200/07 ,  C07C37/002 ,  C07C41/26 ,  C07C213/00 ,  C07C2102/08 ,  C07C2102/10 ,  C07C2602/08 ,  C07C2602/10 ,  C07C33/22 ,  C07C33/20 ,  C07C33/46 ,  C07C43/23 ,  C07C39/11 ,  C07C33/24 ,  C07C33/18 ,  C07C35/36 ,  C07C35/32 ,  C07C215/68

摘要： The invention relates to an asymmetric hydrogenation method for ketone compounds, comprising the step of: under hydrogen atmosphere, in the presence of an in situ catalyst derived from a chiral ligand and a ruthenium salt, adding a ketone compound and a base into a second solvent to carry out an asymmetric hydrogenation for the ketone compound. The invention can obtain a conversion of 100% and a highest asymmetric inducement effect of 99.7% for the ketone compound. The invention has the advantages including simple procedure, high conversion and selectivity, good atom economy and good prospect of industrial application.

摘要翻译： 本发明涉及酮化合物的不对称氢化方法，包括以下步骤：在氢气氛下，在衍生自手性配体和钌盐的原位催化剂存在下，将酮化合物和碱加入到第二溶剂中 对酮化合物进行不对称氢化。 本发明可以获得酮化合物的100％转化率和99.7％的最高不对称诱导效果。 本发明具有工艺简单，转化率高，选择性好，原子经济性好，工业应用前景好的优点。

公开(公告)号：US08962852B2

公开(公告)日：2015-02-24

申请号：US13447632

申请日：2012-04-16

申请人： Wanbin Zhang ,  Delong Liu ,  Hui Guo ,  Yangang Liu

发明人： Wanbin Zhang ,  Delong Liu ,  Hui Guo ,  Yangang Liu

IPC分类号： C07F15/00 ,  C07C29/145 ,  C07C37/00 ,  C07C41/26 ,  C07C213/00 ,  C07B53/00

CPC分类号： C07C29/145 ,  C07B53/00 ,  C07B2200/07 ,  C07C37/002 ,  C07C41/26 ,  C07C213/00 ,  C07C2102/08 ,  C07C2102/10 ,  C07C2602/08 ,  C07C2602/10 ,  C07C33/22 ,  C07C33/20 ,  C07C33/46 ,  C07C43/23 ,  C07C39/11 ,  C07C33/24 ,  C07C33/18 ,  C07C35/36 ,  C07C35/32 ,  C07C215/68

摘要： The invention relates to an asymmetric hydrogenation method for ketone compounds, comprising the step of: under hydrogen atmosphere, in the presence of an in situ catalyst derived from a chiral ligand and a ruthenium salt, adding a ketone compound and a base into a second solvent to carry out an asymmetric hydrogenation for the ketone compound. The invention can obtain a conversion of 100% and a highest asymmetric inducement effect of 99.7% for the ketone compound. The invention has the advantages including simple procedure, high conversion and selectivity, good atom economy and good prospect of industrial application.

摘要翻译： 本发明涉及酮化合物的不对称氢化方法，包括以下步骤：在氢气氛下，在衍生自手性配体和钌盐的原位催化剂存在下，将酮化合物和碱加入到第二溶剂中 对酮化合物进行不对称氢化。 本发明可以获得酮化合物的100％转化率和99.7％的最高不对称诱导效果。 本发明具有工艺简单，转化率高，选择性好，原子经济性好，工业应用前景好的优点。

公开(公告)号：US06628395B2

公开(公告)日：2003-09-30

申请号：US10093787

申请日：2002-03-06

申请人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

发明人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

IPC分类号： G01N2159

CPC分类号： G01N21/474 ,  G01F23/292 ,  G01F23/2928 ,  G01N21/255 ,  G01N21/51 ,  G01N21/55

摘要： A device and method for performing a preliminary test on a neat serum sample contained in a primary collection tube is provided herein. The method includes the steps of positioning of an optical probe near the primary collection tube and monitoring the neat serum sample in the primary collection tube to determine whether an interferant, such as hemolysis, icteris and lipemia are present in the serum sample. From this test, a hemolytic index, an icteric index and a lipemic index can also be established for the neat serum sample. Based upon these serum indices, the neat serum sample can be transferred to a clinical analyzer for additional testing or to waste receptacle because the sample is compromised. Additionally, a volume test can be performed on the serum sample in the primary collection tube so that the serum sample can be properly allocated during subsequent testing.

公开(公告)号：US06388750B1

公开(公告)日：2002-05-14

申请号：US09213736

申请日：1998-12-17

申请人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

发明人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

IPC分类号： G01N2159

CPC分类号： G01N21/474 ,  G01F23/292 ,  G01F23/2928 ,  G01N21/255 ,  G01N21/51 ,  G01N21/55

摘要： A device and method for performing a preliminary test on a neat serum sample contained in a primary collection tube is provided herein. The method includes the steps of positioning of an optical probe near the primary collection tube and monitoring the neat serum sample in the primary collection tube to determine whether an interferant, such as hemolysis, icteris and lipemia are present in the serum sample. From this test, a hemolytic index, an icteric index and a lipemic index can also be established for the neat serum sample. Based upon these serum indices, the neat serum sample can be transferred to a clinical analyzer for additional testing or to waste receptacle because the sample is compromised. Additionally, a volume test can be performed on the serum sample in the primary collection tube so that the serum sample can be properly allocated during subsequent testing.

摘要翻译： 本文提供了对包含在初级收集管中的纯净血清样品进行初步测试的装置和方法。 该方法包括以下步骤：将光学探针定位在主收集管附近并监测初级收集管中的纯血清样品，以确定血清样品中是否存在干扰素，如溶血，黄疸和血脂。 从该测试中，也可以为纯血清样品建立溶血指数，黄疸指数和血液指数。 基于这些血清指数，纯血清样品可以转移到临床分析仪进行额外的测试或废物容器，因为样品受损。 另外，可以对初级收集管中的血清样品进行体积测试，使得在随后的测试期间可以适当地分配血清样品。