公开(公告)号：US06542241B1

公开(公告)日：2003-04-01

申请号：US09518295

申请日：2000-03-03

申请人： Guenter Thorwirth ,  Werner Reiland

发明人： Guenter Thorwirth ,  Werner Reiland

IPC分类号： G01N2159

CPC分类号： G01N21/6452 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00707 ,  G01N21/31

摘要： An arrangement is disclosed for optically reading out the information from substrates having a multiplicity of individual samples, in particular for analyzing chemical and biological sample carriers. The arrangement presents a new possibility for optically reading out the information from matrix-type substrates having a multiplicity of individual samples which allows a fast read-out of a radiation which is influenced by the individual samples with a high degree of sensitivity. This possibility is achieved by the fact that, in the case of optically reading a matrix-type substrate having a multiplicity of metrically ordered pixels, the receiver that is provided is an individual receiver which has high sensitivity and a uniform receiver area, an electrooptical matrix and also an imaging optical system are present, each substrate pixel being assigned to a matrix pixel region by the imaging optical system, and the matrix can be driven in such a way that matrix regions which allow exclusively the feeding of radiation from a substrate pixel to the receiver can be switched separately. Radiation quantities from in each case at least one substrate pixel successively impinging on the receiver over a suitably chosen time interval. The result is that it is possible to evaluate a series of measured radiation quantities from selected sequences of substrate pixels at the output of the receiver.

摘要翻译： 公开了一种用于从具有多个单独样品的衬底光学读出信息的装置，特别是用于分析化学和生物样品载体。 该布置提供了从具有多个单独样本的矩阵型衬底光学读出信息的新的可能性，其允许以高灵敏度快速读出受各个样品影响的辐射。 这种可能性通过以下事实实现：在光学读取具有多个有秩序像素的矩阵型衬底的情况下，所提供的接收器是具有高灵敏度和均匀接收器面积的单独接收器，电光矩阵 并且还存在成像光学系统，每个基板像素由成像光学系统分配给矩阵像素区域，并且可以以这样的方式驱动矩阵，使得仅允许从衬底像素馈送辐射的矩阵区域 接收机可以单独切换。 在每种情况下，至少一个衬底像素在适当选择的时间间隔上连续地照射在接收器上的辐射量。 结果是可以在接收器的输出处评估来自选定的衬底像素序列的一系列测量的辐射量。

公开(公告)号：US06496260B1

公开(公告)日：2002-12-17

申请号：US09220177

申请日：1998-12-23

申请人： Dean G. Hafeman ,  Calvin Y. Chow

发明人： Dean G. Hafeman ,  Calvin Y. Chow

IPC分类号： G01N2159

CPC分类号： G01J3/08 ,  G01J3/1804 ,  G01N21/253 ,  G01N21/31 ,  G01N21/314 ,  G01N21/6452

摘要： Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical pathlength of liquid samples containing the solvent. This relationship is used to establish the optical pathlength for samples containing an unknown concentration of analyte but having similar solvent composition. Further disclosed are methods and devices for determining the concentration of analyte in such samples where both the optical pathlength and the concentration of analyte are unknown. The methods and devices rely on separately determining, at different wavelengths of light, light absorption by the solvent and light absorption by the analyte. Light absorption by the analyte, together with the optical pathlength so determined, is used to calculate the concentration of the analyte. Devices for carrying out the methods particularly advantageously include vertical-beam photometers containing samples disposed within the wells of multi-assay plates, wherein the photometer is able to monitor light absorption of each sample at multiple wavelengths, including in the visible or UV-visible region of the spectrum, as well as in the near-infrared region of the electromagnetic spectrum. Novel photometer devices are described which automatically determine the concentration of analytes in such multi-assay plates directly without employing a standard curve.

摘要翻译： 公开了用于确定含有溶解或悬浮在溶剂中的分析物的液体样品的光程长度的光度测定方法和装置。 所述方法和装置依赖于确定溶剂的光吸收性质和含有溶剂的液体样品的光程长度之间的关系。 该关系用于建立含有未知浓度的分析物但具有相似溶剂组成的样品的光程。 进一步公开了用于确定样品中分析物浓度的方法和装置，其中光程长和分析物浓度都是未知的。 方法和装置依赖于在不同波长的光下分别确定溶剂的光吸收和被分析物的光吸收。 被分析物的光吸收以及如此确定的光程长度被用于计算分析物的浓度。 用于实施方法的装置特别有利地包括垂直光束光度计，其包含设置在多测定板的孔内的样品，其中光度计能够监测包括在可见光或可见光区域中的多个波长的每个样品的光吸收 的光谱，以及在电磁光谱的近红外区域。 描述了新的光度计装置，其直接在不使用标准曲线的情况下自动确定这种多测定板中的分析物的浓度。

公开(公告)号：US06175420B1

公开(公告)日：2001-01-16

申请号：US09082086

申请日：1998-05-20

申请人： Donald Barry ,  Glen Jorgensen ,  Bruce H. Edwards ,  Jeremy Fennelly

发明人： Donald Barry ,  Glen Jorgensen ,  Bruce H. Edwards ,  Jeremy Fennelly

IPC分类号： G01N2159

CPC分类号： G01N21/31

摘要： An optical sensor is disclosed for use in an interactive cell processing system that includes a plurality of sensors arranged for monitoring and providing sensor data to a control module that directs processing of biological cells. The sensors including an optical sensor for characterizing a fluid transferred in a sterile manner during the processing. The optical sensor includes a light source, a light detector, a cuvette and a control circuit. The light source is connected to a control circuit and is constructed and arranged to emit light of at least one selected wavelength directed toward the fluid. The cuvette is constructed as a part of a fluid distribution manifold that includes several conduits for transferring the sterile fluid during the processing, wherein the cuvette is constructed and arranged to convey the fluid. The light detector is connected to the control circuit and is constructed and arranged to detect light that was emitted from the source and has interacted with the fluid flowing inside the cuvette. The control circuit is constructed and arranged to characterize the fluid in the cuvette based on the detected light.

摘要翻译： 公开了一种用于交互式电池处理系统中的光学传感器，该系统包括多个传感器，其布置成用于监视并向控制模块提供传感器数据，该控制模块指导生物细胞的处理。 传感器包括用于表征处理期间以无菌方式转移的流体的光学传感器。 光学传感器包括光源，光检测器，比色皿和控制电路。 光源连接到控制电路，并被构造和布置成发射指向流体的至少一个选定波长的光。 试管被构造为流体分配歧管的一部分，其包括用于在处理期间传送无菌流体的多个导管，其中反应杯被构造和布置成输送流体。 光检测器连接到控制电路，并被构造和布置成检测从源发射并与在比色皿内流动的流体相互作用的光。 控制电路被构造和布置成基于检测到的光来表征比色皿中的流体。

公开(公告)号：US06788414B1

公开(公告)日：2004-09-07

申请号：US10070531

申请日：2002-06-05

申请人： Edward S. Yeung ,  Xiaoyi Gong

发明人： Edward S. Yeung ,  Xiaoyi Gong

IPC分类号： G01N2159

CPC分类号： G01N30/95 ,  B01J2219/00522 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00707 ,  G01N21/253 ,  G01N21/31 ,  G01N27/44721 ,  G01N27/44782 ,  G01N30/74 ,  G01N30/466

摘要： The present invention provides a method of analyzing multiple samples simultaneously by absorption detection. The method comprises: (i) providing a planar array of multiple containers, each of which contains a sample comprising at least one absorbing species, (ii) irradiating the planar array of multiple containers with a light source and (iii) detecting absorption of light with a detetion means that is in line with the light source at a distance of at leaat about 10 times a cross-sectional distance of a container in the planar array of multiple containers. The absorption of light by a sample indicates the presence of an absorbing species in it. The method can further comprise: (iv) measuring the amount of absorption of light detected in (iii) indicating the amount of the absorbing species in the sample. Also provided by the present invention is a system for use in the abov metho.The system comprises; (i) a light source comrnpising or consisting essentially of at leaat one wavelength of light, the absorption of which is to be detected, (ii) a planar array of multiple containers, and (iii) a detection means that is in line with the light source and is positioned in line with and parallel to the planar array of multiple contiainers at a distance of at least about 10 times a cross-sectional distance of a container.

摘要翻译： 本发明提供了通过吸收检测同时分析多个样品的方法。 该方法包括：（i）提供多个容器的平面阵列，每个容器包含包含至少一个吸收物质的样品，（ii）用光源照射多个容器的平面阵列，以及（iii）检测光的吸收 具有与多个容器的平面阵列中的容器的横截面距离的至少约10倍的距离与光源一致的检测装置。 样品对光的吸收表明其中存在吸收物质。 该方法还可以包括：（iv）测量在（iii）中检测到的光的吸收量，指示样品中吸收物质的量。 本发明还提供了一种在上述方法中使用的系统。 （i）光源，其包括或基本上由至少一个波长的光，其吸收被检测，（ii）多个容器的平面阵列，以及（iii）检测装置，其符合 光源并且与容器的横截面距离的至少约10倍的距离定位成与多个容器的平面阵列成直线并平行。

公开(公告)号：US06748342B1

公开(公告)日：2004-06-08

申请号：US09959071

申请日：2002-01-18

申请人： Bertold Dickhaus

发明人： Bertold Dickhaus

IPC分类号： G01N2159

CPC分类号： H04B10/0775 ,  H04B10/07953 ,  H04B10/07955 ,  H04B2210/078

摘要： The method and respective device monitors the quality of data transmission over wavelength-division-multiplexed channels on an optical waveguide using an analog check signal. The analog check signal is formed by decoupling and combining a fraction p of the signals of each of the wavelengths being monitored at a starting point of a monitoring path, and is then transmitted on an additional wavelength in parallel with the wavelengths being monitored. At a monitoring point on the monitoring path provided for the purpose, a fraction p of the signals on the wavelengths being monitored are decoupled again, as well as at least a fraction of the analog check signal. These decoupled signals are evaluated in order to determine if these has been any change in the intensities of the signals on the wavelengths being monitored between the starting point and the monitoring point.

摘要翻译： 该方法和各自的设备使用模拟检查信号监视光波导上的波分复用信道上的数据传输质量。 模拟检查信号通过在监测路径的起点处去除和组合被监测的每个波长的信号的分数p并且然后与被监测的波长并行地以附加波长传输而形成。 在为此目的提供的监控路径上的监测点，被监测的波长上的信号的分数p再次去耦，以及模拟检查信号的至少一部分。 对这些去耦信号进行评估，以确定这些信号是否已经在起始点和监测点之间被监测的波长上的信号强度有任何变化。

公开(公告)号：US06436717B1

公开(公告)日：2002-08-20

申请号：US09509299

申请日：2000-03-23

申请人： Huan Ping Wu

发明人： Huan Ping Wu

IPC分类号： G01N2159

CPC分类号： G01N21/80 ,  G01N21/7703 ,  G01N21/78 ,  G01N21/8507 ,  Y10T436/204998

摘要： The invention comprises a method for determining an analyte in which a dye solution is illuminated to induce a first and a second output light at a first and second wavelength, respectively, and the analyte concentration is determined from the measured first and second output intensities. The apparatus includes a probe (12) containing a dye solution, a light source (24), a frequency-sensitive photodetector (28) and a controller (90).

摘要翻译： 本发明包括一种用于测定分析物的方法，其中染料溶液被照射以分别诱导第一和第二波长的第一和第二输出光，并且从所测量的第一和第二输出强度确定分析物浓度。 该装置包括含有染料溶液的探针（12），光源（24），频敏光电检测器（28）和控制器（90）。

公开(公告)号：US06678052B1

公开(公告)日：2004-01-13

申请号：US09677612

申请日：2000-10-03

申请人： Vijay Kumar Millikarjun Hanagandi ,  Mark Erik Nelson ,  Ravi Rajamani

发明人： Vijay Kumar Millikarjun Hanagandi ,  Mark Erik Nelson ,  Ravi Rajamani

IPC分类号： G01N2159

CPC分类号： G01N21/85 ,  G01N2021/8557

摘要： An on-line sensor is provided that supplies light to a spectrophotometer to measure the color a product extruded through a conduit having a bypass section. The on-line sensor includes a transparent member with an opaque outer surface and an interior portion extending from a first end to a second end to the transparent member. The interior portion is connected to the bypass section, and the product that flows through the bypass section is supplied to the interior section of the transparent member. A light source connected to the transparent member and provides light to the transparent member inside the opaque outer surface. A light receiver is connected to the transparent member and captures light from the light source in the transparent member that is affected by the product. The captured light is supplied to the spectrophotometer to at least measure the properties of the product supplied to the interior portion of the transparent member.

摘要翻译： 提供在线传感器，其向分光光度计提供光以测量通过具有旁路部分的导管挤出的产品的颜色。 在线传感器包括具有不透明外表面的透明构件和从第一端延伸到第二端到透明构件的内部部分。 内部部分连接到旁路部分，并且流过旁路部分的产品被供应到透明部件的内部。 连接到透明构件并在不透明外表面内部向透明构件提供光的光源。 光接收器连接到透明构件并且捕获来自受产品影响的透明构件中的光源的光。 捕获的光被提供到分光光度计以至少测量供应到透明构件的内部的产品的性质。

公开(公告)号：US06657726B1

公开(公告)日：2003-12-02

申请号：US09643830

申请日：2000-08-18

申请人： Yuchun Wang ,  Boguslaw Swedek

发明人： Yuchun Wang ,  Boguslaw Swedek

IPC分类号： G01N2159

CPC分类号： G01B11/28 ,  B24B49/12 ,  B24B57/02 ,  G01B11/06

摘要： A method and apparatus for measuring a slurry distribution. A slurry solution is doped with a light absorbing dye having an absorptivity sensitive to a physical parameter such as acidity, temperature or pressure. The solution is delivered between a platen and substrate in a first physical state where it absorbs light. A laser beam is generated, transmitted through the slurry layer, reflected off of the substrate, and detected by a photodetector. The thickness of the slurry is measured from its absorptivity and the transmittance of the laser beam. A relative motion between the light source and substrate allows the slurry layer thickness to be measured as a function of distance from the center of the substrate. A final water rinse removes the slurry and brings any residual slurry to a/second physical state where it does not absorb light.

摘要翻译： 一种用于测量浆料分布的方法和装置。 浆料溶液掺杂有对诸如酸度，温度或压力的物理参数敏感的吸收性的吸光染料。 溶液在其吸收光的第一物理状态下在压板和衬底之间传送。 产生激光束，透过浆料层，从衬底反射出来，由光电检测器检测。 从其吸收率和激光束的透射率测量浆料的厚度。 光源和衬底之间的相对运动允许测量浆料层厚度作为距离衬底中心的距离的函数。 最终的水冲洗去除浆料并将任何残留的浆料带入不吸收光的第二物理状态。

公开(公告)号：US06628395B2

公开(公告)日：2003-09-30

申请号：US10093787

申请日：2002-03-06

申请人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

发明人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

IPC分类号： G01N2159

CPC分类号： G01N21/474 ,  G01F23/292 ,  G01F23/2928 ,  G01N21/255 ,  G01N21/51 ,  G01N21/55

摘要： A device and method for performing a preliminary test on a neat serum sample contained in a primary collection tube is provided herein. The method includes the steps of positioning of an optical probe near the primary collection tube and monitoring the neat serum sample in the primary collection tube to determine whether an interferant, such as hemolysis, icteris and lipemia are present in the serum sample. From this test, a hemolytic index, an icteric index and a lipemic index can also be established for the neat serum sample. Based upon these serum indices, the neat serum sample can be transferred to a clinical analyzer for additional testing or to waste receptacle because the sample is compromised. Additionally, a volume test can be performed on the serum sample in the primary collection tube so that the serum sample can be properly allocated during subsequent testing.

公开(公告)号：US06388750B1

公开(公告)日：2002-05-14

申请号：US09213736

申请日：1998-12-17

申请人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

发明人： Yangang Liu ,  Tung Rung Wang ,  Ian Nguyen ,  Shirley Pfeifer ,  Jack McNeal

IPC分类号： G01N2159

CPC分类号： G01N21/474 ,  G01F23/292 ,  G01F23/2928 ,  G01N21/255 ,  G01N21/51 ,  G01N21/55

摘要： A device and method for performing a preliminary test on a neat serum sample contained in a primary collection tube is provided herein. The method includes the steps of positioning of an optical probe near the primary collection tube and monitoring the neat serum sample in the primary collection tube to determine whether an interferant, such as hemolysis, icteris and lipemia are present in the serum sample. From this test, a hemolytic index, an icteric index and a lipemic index can also be established for the neat serum sample. Based upon these serum indices, the neat serum sample can be transferred to a clinical analyzer for additional testing or to waste receptacle because the sample is compromised. Additionally, a volume test can be performed on the serum sample in the primary collection tube so that the serum sample can be properly allocated during subsequent testing.

摘要翻译： 本文提供了对包含在初级收集管中的纯净血清样品进行初步测试的装置和方法。 该方法包括以下步骤：将光学探针定位在主收集管附近并监测初级收集管中的纯血清样品，以确定血清样品中是否存在干扰素，如溶血，黄疸和血脂。 从该测试中，也可以为纯血清样品建立溶血指数，黄疸指数和血液指数。 基于这些血清指数，纯血清样品可以转移到临床分析仪进行额外的测试或废物容器，因为样品受损。 另外，可以对初级收集管中的血清样品进行体积测试，使得在随后的测试期间可以适当地分配血清样品。