摘要:
PAD4 inhibitory compositions and methods for their use in treatment of cancer and autoimmune disease are provided according to embodiments of the present invention.
摘要:
PAD4 inhibitory compositions and methods for their use in treatment of cancer and autoimmune disease are provided according to embodiments of the present invention.
摘要:
A method of preparing a tobacco material for use in a smoking article is provided, including (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof; (ii) heating the mixture; and (iii) incorporating the heat-treated mixture into a smoking article as a smokable material. A smoking article in the form of a cigarette is also provided that includes a tobacco material pre-treated to inhibit reaction of asparagine to form acrylamide in mainstream smoke. Upon smoking, the smoking article is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article.
摘要:
A meltable smokeless tobacco composition configured for insertion into the mouth of a user is provided. The smokeless tobacco composition includes a particulate tobacco material and a lipid having a melting point of about 36° C. to about 45° C. An associated process is also provided. The process includes melting a lipid having a melting point of about 36° C. to about 45° C. to form a molten lipid composition, mixing a particulate tobacco material with the molten lipid composition to form a molten smokeless tobacco composition slurry, and cooling the molten smokeless tobacco composition slurry to form a solidified smokeless tobacco composition.
摘要:
A photomask may include a patterned layer, a phase-shift layer adjacent the patterned layer, a first aperture, a second aperture, and a light-absorbing layer. The first aperture may allow light to pass through the patterned layer and the phase-shift layer and provide a first phase shift. The second aperture may allow light to pass through the patterned layer and the phase-shift layer and provide a second phase shift different than the first phase-shift. The light-absorbing layer may be disposed adjacent the first aperture and may include a light-absorbing material that reduces the intensity of light passing through the first aperture such that the intensity of light passing through the first aperture is substantially equal to the intensity of light passing through the second aperture.
摘要:
A diesel engine (10) wherein both the operating speed of the engine (RPM) and the timing of the fuel injection into the engine (AA) are cooperatively controlled to be responsive to both the temperature and the pressure of the air (30) used for combustion. A controller (44) receives a temperature signal (28), an air pressure signal (36), and a power demand signal (24) and executes control logic to produce a fuel injection control signal (46) and an engine speed control signal (48) for controlling a fuel injection system (16). A control strategy based on engine inlet air temperature and pressure or manifold air density may be useful for variable speed and power applications. For applications with discreet speed and power points, such as a locomotive, a speed and timing control strategy based on ambient temperature and pressure is useful for maximizing power during high altitude and/or high ambient/inlet air temperature operation.
摘要:
Automatic control of the temperature of the inlet air being supplied to the engine (12) of a locomotive (10) in order to optimize the performance of the engine (12) under a variety of ambient air temperatures and pressures. One or more valves (38) is utilized to control the flow of warm air from the engine compartment (14) into the air inlet path (20). The position of valve (38) is controlled by controller (42) in response to at least one of an ambient air temperature signal TA, an ambient atmospheric pressure signal PA, and an inlet air temperature signal TI. The temperature of the air flowing through the warm air flow path 28 may be controlled by selecting from among a plurality of possible inlets (30, 32, 50). By varying the volume and temperature of the air flowing through the warm air flow path (28), the temperature and density of the air supplied at the engine inlet (18) may be moderated across a broad range of ambient air temperatures and pressures.
摘要:
A method for alignment in photolithographic processes includes providing a target (31) comprising features having a characteristic spatial period (P). An optical image of the target is captured, and components (33) of the image lacking the characteristic spatial period (P) are filtered out. The filtered image is integrated in the direction of the characteristic period (P) thereby creating an alignment signal (40). The alignment signal (40) is a symmetric signal which correlates to the symmetric target (31). A linear centroid (41) of the alignment signal is located, and corresponds to the precise linear center of the target (31). Consequently, the linear location of an object (10) upon which the target (31) is printed, can be accurately located. The process is performed in two perpendicular dimensions (x,y) so that the object (10) can be precisely located and positioned in two dimensions (x,y).
摘要:
A laser using a distributed phase shift structure is disclosed. The active medium is formed in the shape of a stripe having first and second surfaces and two ends. The stripe includes a large central portion and two end portions with the central portion being of different widths than the two end portions. A laser device which utilizes the active medium of the present invention further includes at least one P-guide layer and at least one N-guide layer, both having a higher bandgap energy than the active medium. The P-guide layer and the N-guide layer are located on opposing surfaces of the active medium. A current which is injected through the N-guide layer, the P-guide layer and the active medium induces single mode, narrow linewidth coherent light to issue from the active medium.
摘要:
A method is provided for curing tobacco. The method includes steps of wilting, bruising, aerating, and drying tobacco, where each of the steps is measured in hours or days rather than months. In some aspects, aeration may take two to twelve hours or less. In some aspects, the entire curing method may be completed in 24 hours or less.