公开(公告)号：US20080009444A1

公开(公告)日：2008-01-10

申请号：US11704086

申请日：2007-02-08

申请人： Andrew Nash ,  Kim Jachno ,  Louis Fabri ,  Kate Reid ,  Perry Bartlett ,  Douglas Hilton ,  Yasuhiko Nakata ,  Masakazu Hasegawa

发明人： Andrew Nash ,  Kim Jachno ,  Louis Fabri ,  Kate Reid ,  Perry Bartlett ,  Douglas Hilton ,  Yasuhiko Nakata ,  Masakazu Hasegawa

IPC分类号： A61K38/22 ,  A61K38/02 ,  A61P43/00 ,  C07H21/00 ,  C07K14/00 ,  C07K14/575 ,  C07K16/00 ,  C07K2/00 ,  C12N15/63 ,  G01N33/68

CPC分类号： E05B63/06 ,  E05B17/0012 ,  E05B17/0062 ,  E05B17/06 ,  E05C9/021 ,  E05C9/1808 ,  E05C9/185 ,  Y10T292/0843 ,  Y10T292/0993 ,  Y10T292/432

摘要： The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.

摘要翻译： 本发明一般涉及包含至少两个异源分子的生物活性复合物。 更具体地，本发明的生物活性复合物包含一种或多种多肽的至少两种多肽或部分，片段，截短物或蛋白酶活化形式，其中单独或与受体，配体或其它分子缔合的复合物有助于 细胞的增殖，分化和/或存活。 本发明的生物活性复合物的鉴定允许激活剂和拮抗剂测定生物活性复合物的形成以及基于生物活性复合物或生物活性复合物与受体之间相互作用的治疗和诊断试剂， 配体或其他分子。

公开(公告)号：US07192576B1

公开(公告)日：2007-03-20

申请号：US10110172

申请日：2000-10-06

申请人： Andrew Nash ,  Kim Maree Jachno ,  Louis J. Fabri ,  Kate Reid ,  Perry F. Bartlett ,  Douglas J. Hilton ,  Yasuhiko Nakata ,  Masakazu Hasegawa

发明人： Andrew Nash ,  Kim Maree Jachno ,  Louis J. Fabri ,  Kate Reid ,  Perry F. Bartlett ,  Douglas J. Hilton ,  Yasuhiko Nakata ,  Masakazu Hasegawa

IPC分类号： C12N15/19 ,  C12N15/63 ,  A61K38/19 ,  C07K14/52

CPC分类号： C07K14/715 ,  A61K38/00 ,  A61K48/00 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.

摘要翻译： 本发明一般涉及包含至少两个异源分子的生物活性复合物。 更具体地，本发明的生物活性复合物包含一种或多种多肽的至少两种多肽或部分，片段，截短物或蛋白酶活化形式，其中单独或与受体，配体或其它分子缔合的复合物有助于 细胞的增殖，分化和/或存活。 本发明的生物活性复合物的鉴定允许激活剂和拮抗剂测定生物活性复合物的形成，以及基于生物活性复合物或生物活性复合物与受体之间相互作用的治疗和诊断试剂， 配体或其他分子。