-
1.发明申请公开(公告)号：US20080009444A1
公开(公告)日：2008-01-10
申请号：US11704086
申请日：2007-02-08
申请人： Andrew Nash , Kim Jachno , Louis Fabri , Kate Reid , Perry Bartlett , Douglas Hilton , Yasuhiko Nakata , Masakazu Hasegawa
发明人： Andrew Nash , Kim Jachno , Louis Fabri , Kate Reid , Perry Bartlett , Douglas Hilton , Yasuhiko Nakata , Masakazu Hasegawa
IPC分类号： A61K38/22 , A61K38/02 , A61P43/00 , C07H21/00 , C07K14/00 , C07K14/575 , C07K16/00 , C07K2/00 , C12N15/63 , G01N33/68
CPC分类号： E05B63/06 , E05B17/0012 , E05B17/0062 , E05B17/06 , E05C9/021 , E05C9/1808 , E05C9/185 , Y10T292/0843 , Y10T292/0993 , Y10T292/432
摘要： The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.
摘要翻译： 本发明一般涉及包含至少两个异源分子的生物活性复合物。 更具体地，本发明的生物活性复合物包含一种或多种多肽的至少两种多肽或部分，片段，截短物或蛋白酶活化形式，其中单独或与受体，配体或其它分子缔合的复合物有助于 细胞的增殖，分化和/或存活。 本发明的生物活性复合物的鉴定允许激活剂和拮抗剂测定生物活性复合物的形成以及基于生物活性复合物或生物活性复合物与受体之间相互作用的治疗和诊断试剂， 配体或其他分子。
-
2.发明授权公开(公告)号：US07192576B1
公开(公告)日：2007-03-20
申请号：US10110172
申请日：2000-10-06
申请人： Andrew Nash , Kim Maree Jachno , Louis J. Fabri , Kate Reid , Perry F. Bartlett , Douglas J. Hilton , Yasuhiko Nakata , Masakazu Hasegawa
发明人： Andrew Nash , Kim Maree Jachno , Louis J. Fabri , Kate Reid , Perry F. Bartlett , Douglas J. Hilton , Yasuhiko Nakata , Masakazu Hasegawa
CPC分类号： C07K14/715 , A61K38/00 , A61K48/00 , C07K14/52 , C07K2319/00
摘要： The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.
摘要翻译： 本发明一般涉及包含至少两个异源分子的生物活性复合物。 更具体地，本发明的生物活性复合物包含一种或多种多肽的至少两种多肽或部分，片段，截短物或蛋白酶活化形式，其中单独或与受体，配体或其它分子缔合的复合物有助于 细胞的增殖，分化和/或存活。 本发明的生物活性复合物的鉴定允许激活剂和拮抗剂测定生物活性复合物的形成，以及基于生物活性复合物或生物活性复合物与受体之间相互作用的治疗和诊断试剂， 配体或其他分子。
-
公开(公告)号：US08474439B2
公开(公告)日：2013-07-02
申请号：US12772272
申请日：2010-05-03
CPC分类号： F02M25/0836 , F02M25/0854 , F02M25/0872 , F02M25/089 , F02M37/0023 , F02M37/0052 , F02M37/025 , F02M37/106 , F02M37/20
摘要： A fuel vapor processor has a fuel tank, a canister, a recovery pipe, a fuel pump, a negative pressure generator, a pressure regulator, a fuel intake pipe and a fuel intake regulator. The vapor pipe leads the fuel vapor generated in the fuel tank into the canister for trapping the fuel vapor. The recovery pipe connects the fuel tank and the canister for recovering the fuel vapor trapped in the canister into the fuel tank. The fuel intake pipe directly connects the fuel pump provided in the fuel tank with the negative pressure generator for leading fuel to the negative pressure generator. The negative pressure generator generates negative pressure depending on an amount of fuel supplied to the negative pressure generator from the fuel pump. The fuel vapor trapped in the canister is recovered to the fuel tank through the recovery pipe due to the negative pressure. The pressure regulator is connected with the fuel pump for returning excess fuel discharged from the fuel pump into the fuel tank. The fuel intake regulator disposed on the fuel intake pipe controls the amount of the fuel supplied to the negative pressure generator from the fuel pump.
摘要翻译： 燃料蒸汽处理器具有燃料箱，罐，回收管，燃料泵，负压发生器，压力调节器，燃料进入管和燃料进入调节器。 蒸汽管将燃料箱中产生的燃料蒸气引导到罐中以捕获燃料蒸气。 回收管连接燃料箱和罐，用于将容纳在罐中的燃料蒸汽回收到燃料箱中。 燃料吸入管直接将设置在燃料箱中的燃料泵与用于引导燃料的负压发生器连接到负压发生器。 负压发生器根据从燃料泵供给到负压发生器的燃料量产生负压。 捕获在罐中的燃料蒸气由于负压而通过回收管被回收到燃料箱。 压力调节器与燃料泵连接，用于将从燃料泵排出的多余的燃料返回到燃料箱中。 设置在燃料吸入管上的燃料进入调节器控制从燃料泵供给到负压发生器的燃料量。
-
公开(公告)号：US20100310556A1
公开(公告)日：2010-12-09
申请号：US12746229
申请日：2008-12-05
IPC分类号： A61K39/395
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/76
摘要： The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus.
摘要翻译： 本发明人从人抗体噬菌体文库中分离克隆BM095，其在IL-31依赖性Ba / F3细胞生长测定系统中具有强的生长抑制活性。 当施用于瘙痒模型小鼠时，抗小鼠NR10中和抗体表现出明显的症状抑制作用。 因此，显示抗NR10中和抗体可用作瘙痒的治疗剂。
-
公开(公告)号：US08518164B2
公开(公告)日：2013-08-27
申请号：US13192645
申请日：2011-07-28
IPC分类号： B01D53/02
摘要： An adsorbent canister has a housing defining an adsorption chamber therein, an adsorbent filled in the adsorption chamber, and a honeycomb core. The honeycomb core is made from a material having a higher thermal conductivity than the adsorbent, defines therein a plurality of cells passing through the honeycomb core and is disposed in the adsorption chamber. The adsorbent canister can further have a heater for heating the honeycomb core or the honeycomb core can be made from a material, which produce heat when current is applied.
-
公开(公告)号：US20100055092A1
公开(公告)日：2010-03-04
申请号：US12303684
申请日：2007-06-08
IPC分类号： A61K39/395 , C07K16/00 , A61P29/00
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/54 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.
摘要翻译： 本发明人从人抗体的噬菌体文库获得了在IL-31依赖性Ba / F3细胞增殖分析系统中显示出强的增殖抑制活性的抗小鼠NR10中和抗体表达BM095克隆。 当向NC / Nga小鼠施用这种抗小鼠NR 10中和抗体时，是由于重复使用苦基氯，类风湿性关节炎的小鼠模型和由此引起的慢性皮炎小鼠模型的特应性皮炎模型 观察到骨关节炎的小鼠模型，观察到症状抑制的显着作用。 这表明抗NR10中和抗体确实作为炎性疾病的治疗剂有效。 此外，本发明人成功地获得了抗人NR10中和抗体，其具有实用的临床应用的非常有用的治疗剂。
-
公开(公告)号：US06309561B1
公开(公告)日：2001-10-30
申请号：US08998400
申请日：1997-12-24
申请人： Masakazu Hasegawa , Michael P. Keyes , Marc D. Radcliffe , Patricia M. Savu , Daniel C. Snustad , Terence D. Spawn
发明人： Masakazu Hasegawa , Michael P. Keyes , Marc D. Radcliffe , Patricia M. Savu , Daniel C. Snustad , Terence D. Spawn
IPC分类号： C09K1934
CPC分类号： C07D239/26 , C07D239/34 , C09K19/3405 , C09K19/3463 , C09K19/3469 , C09K19/3491 , C09K19/3497 , C09K2019/3408
摘要： Fluorine-containing, chiral liquid crystal compounds comprise (a) a chiral fluorochemical terminal portion comprising (i) at least one chiral center, which can optionally be heteroatom-substituted; (ii) a terminal fluoroalkyl, fluoroether, perfluoroalkyl, or perfluoroether group; and (iii) an alkylene or fluoroalkylene group optionally containing at least one catenary ether oxygen atom; (b) a chiral or achiral terminal portion consisting of a hydrocarbon or hydrocarbon ether group, and, when chiral, comprising at least one chiral center, which can optionally be heteroatom-substituted; and (c) a central core connecting the terminal portions; the alkylene or fluoroalkylene group of the chiral fluorochemical terminal portion having at least 3 in-chain atoms and being located between the chiral center of the chiral fluorochemical terminal portion and the central core. The compounds have smectic mesophases or latent smectic mesophases and are useful, for example, in liquid crystal display devices.
摘要翻译： 含氟手性液晶化合物包含（a）手性含氟末端部分，其包含（i）至少一个可任选被杂原子取代的手性中心; （ii）末端氟代烷基，氟代醚，全氟烷基或全氟醚基团; 和（iii）任选地含有至少一个链状醚氧原子的亚烷基或氟亚烷基; （b）由烃或烃醚基组成的手性或非手性末端部分，以及当手性包含至少一个手性中心时，该手性中心可任选被杂原子取代; 和（c）连接端子部分的中心芯部; 手性含氟末端部分的亚烷基或氟亚烷基具有至少3个链内原子并且位于手性含氟末端部分的手性中心和中心核心之间。 这些化合物具有近晶中间相或潜在的近晶中间相，并且可用于例如液晶显示装置。
-
公开(公告)号：US4701117A
公开(公告)日：1987-10-20
申请号：US851777
申请日：1986-04-14
申请人： Michio Takaoka , Tsuneaki Motai , Motoyuki Ono , Isao Kaji , Masakazu Hasegawa , Masayuki Tan , Masaru Kurata
发明人： Michio Takaoka , Tsuneaki Motai , Motoyuki Ono , Isao Kaji , Masakazu Hasegawa , Masayuki Tan , Masaru Kurata
CPC分类号： H02G1/145 , B29C33/202 , B29C70/845 , B29C45/00 , B29K2105/24 , B29K2995/0007 , B29L2031/3462
摘要： An apparatus for jointing CV cables includes a lock mechanism which closes a split portion of a mold, used for extrusion-molding and opens the split portion by heat when crosslinking is performed.
摘要翻译： 用于连接CV电缆的装置包括一个闭合模具的分割部分的锁定机构，用于挤出成型，并且在进行交联时通过加热打开分离部分。
-
9.发明授权Method of treating an inflammatory disease comprising administering an NR 10 antibody antagonist 有权治疗炎性疾病的方法，包括施用NR 10抗体拮抗剂公开(公告)号：US09028821B2
公开(公告)日：2015-05-12
申请号：US12303684
申请日：2007-06-08
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/54 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.
摘要翻译： 本发明人从人抗体的噬菌体文库获得了在IL-31依赖性Ba / F3细胞增殖分析系统中显示出强的增殖抑制活性的抗小鼠NR10中和抗体表达BM095克隆。 当向NC / Nga小鼠施用这种抗小鼠NR 10中和抗体时，是由于重复使用苦基氯，类风湿性关节炎的小鼠模型和由此引起的慢性皮炎小鼠模型的特应性皮炎模型 观察到骨关节炎的小鼠模型，观察到症状抑制的显着作用。 这表明抗NR10中和抗体确实作为炎性疾病的治疗剂有效。 此外，本发明人成功地获得了抗人NR10中和抗体，其具有实用的临床应用的非常有用的治疗剂。
-
公开(公告)号：US07673847B2
公开(公告)日：2010-03-09
申请号：US11520037
申请日：2006-09-13
IPC分类号： F16K31/02
CPC分类号： F16K31/0655 , F02D19/024 , F02M21/0254 , F02M21/0266 , Y02T10/32
摘要： A movable valve 131 is movably supported by a support plate 135 within a valve body having a gas injection nozzle 129. The valve body consists of a plurality of members 103, 105, 107, 109, 127. Impermeable joints 147a, 147b, 147c are formed between the members. The support plate 135 includes a plurality of elastically deformable support portions each having an inner radial connection, an outer radial connection and a circumferential connection. The support portions are phase adjusted to radial fluid passages 131h formed in the movable valve 113.
摘要翻译： 可移动阀131由具有气体喷射喷嘴129的阀体内的支撑板135可移动地支撑。阀体由多个构件103,105,107,109,127组成。不透气接头147a，147b，147c是 成员之间形成。 支撑板135包括多个可弹性变形的支撑部分，每个支撑部分具有内径向连接，外径向连接和圆周连接。 支撑部分相对于形成在可动阀113中的径向流体通道131h进行相位调节。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.047 秒)