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    Method for regulating neuron development and maintenance
    3.
    发明授权
    Method for regulating neuron development and maintenance 失效
    调节神经元发育和维持的方法

    公开(公告)号：US06177402B1

    公开(公告)日：2001-01-23

    申请号：US08410402

    申请日：1995-03-27

    申请人： Perry Bartlett ,  Mark Murphy

    发明人： Perry Bartlett ,  Mark Murphy

    IPC分类号： A01N3718

    CPC分类号： A61K38/185 ,  A61K38/2093 ,  A61K2300/00

    摘要： The present invention provides methods for regulating neuron development, regeneration and maintenance by administration of leukemia inhibitory factor (LIF). Pharmaceutical compositions containing LIF and one or more additional neuron stimulating factors are also provided.

    摘要翻译： 本发明提供了通过施用白血病抑制因子（LIF）来调节神经元发育，再生和维持的方法。 还提供了含有LIF和一种或多种另外的神经元刺激因子的药物组合物。

    Method of Treatment
    6.
    发明申请
    Method of Treatment 审中-公开
    治疗方法

    公开(公告)号：US20070270352A1

    公开(公告)日：2007-11-22

    申请号：US10514374

    申请日：2003-05-14

    申请人： Perry Bartlett ,  Elizabeth Coulson ,  Samuel Morley ,  Sarah Hulett

    发明人： Perry Bartlett ,  Elizabeth Coulson ,  Samuel Morley ,  Sarah Hulett

    IPC分类号： A61K31/44 ,  A61K31/7088 ,  A61K38/17 ,  A61P25/28

    CPC分类号： A61K31/14 ,  A61K31/445 ,  A61K31/45 ,  A61K31/7088 ,  A61K38/17 ,  A61K45/06

    摘要： The present invention relates generally to a method for preventing, inhibiting or otherwise reducing cell death. More particularly, the present invention contemplates a method for preventing, inhibiting or otherwise reducing neuronal cell death such as during neurodegenerative disease or following trauma The method of the present invention is generally practiced by the administration to a mammalian including a human subject, of an effective amount of an agent which blocks, retards or otherwise impairs ions from entering or passing through an ion channel. In one particular embodiment, the ion channel is a potassium (K) ion (K+) channel. The present invention further provides compositions comprising ion channel blockers and in particular K+ channel blockers. The compositions may also comprise other therapeutic agents such as agents which reduce levels of, or the activity of, a neurotrophin receptor. The present invention further provides methods for promoting cell survival by promoting intracellular cleavage of the neutrophil receptor by generating or introducing intracellular forms of the receptor such as by genetic or protein supplementation means. The present invention further provides a method for determining the likelihood of neurological cell degeneration by determining the level of function of K+ channels wherein an impaired ion channel is indicative of a reduced likelihood of neuronal cell apoptosis. Furthermore, the present invention provides antagonists of K+ channels, such as antagonists of molecules which mediate K+ channel activation via neurotrophin receptors or domains thereof.

    摘要翻译： 本发明一般涉及一种预防，抑制或以其他方式减少细胞死亡的方法。 更具体地，本发明考虑了一种预防，抑制或以其他方式减少神经元细胞死亡的方法，例如在神经退行性疾病期间或之后的创伤。本发明的方法通常通过向哺乳动物（包括人类受试者）施用有效的方法 阻止，阻滞或以其他方式损害离子进入或通过离子通道的试剂的量。 在一个具体实施方案中，离子通道是钾（K）离子（K +）通道。 本发明还提供了包含离子通道阻断剂，特别是K +通道阻断剂的组合物。 组合物还可以包含其它治疗剂，例如降低神经营养因子受体的水平或活性的试剂。 本发明还提供了通过产生或引入细胞内形式的受体，例如通过遗传或蛋白质补充方法来促进细胞内中性粒细胞受体的切割来促进细胞存活的方法。 本发明还提供了一种通过确定K +通道的功能水平来确定神经系统细胞变性的可能性的方法，其中受损的离子通道表示神经元细胞凋亡的可能性降低。 此外，本发明提供K +通道的拮抗剂，例如通过神经营养因子受体或其结构域介导K +通道活化的分子的拮抗剂。

    Method of modulating cell survival and reagents useful for same
    7.
    发明申请
    Method of modulating cell survival and reagents useful for same 有权
    调节细胞存活的方法和对其有用的试剂

    公开(公告)号：US20050090442A1

    公开(公告)日：2005-04-28

    申请号：US10921065

    申请日：2004-08-18

    申请人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    发明人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  A61K38/17 ,  C12N5/00

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

    摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75 NTR）鉴定的区域介导。 本发明进一步提供编码p75 NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑重组肽，多肽和蛋白质以及其包含p75 NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75 NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75 NTR介导的细胞死亡。

    Methods for the treatment and prophylaxis of demeyelinating disease
    8.
    发明申请
    Methods for the treatment and prophylaxis of demeyelinating disease 审中-公开
    治疗和预防脱髓鞘疾病的方法

    公开(公告)号：US20070212372A1

    公开(公告)日：2007-09-13

    申请号：US11799862

    申请日：2007-05-03

    申请人： Kylie Shipham ,  Tamara Bucci ,  Helmut Butzkueven ,  Trevor Kilpatrick ,  Perry Bartlett ,  Merja Soilu-Hanninen

    发明人： Kylie Shipham ,  Tamara Bucci ,  Helmut Butzkueven ,  Trevor Kilpatrick ,  Perry Bartlett ,  Merja Soilu-Hanninen

    IPC分类号： A61K39/00

    CPC分类号： C07K14/4703 ,  A61K38/2093

    摘要： The present invention relates to a method for the treatment and/or prophylaxis of a nervous system disease, demyelinating disease and/or an inflammatory disease of either the central or peripheral nervous system such as but not limited to an encephalopathic condition and even more particularly an encephalomyelopathic condition. The present invention further provides the use of leukemia inhibitory factor or derivatives, homologues or analogues thereof in the treatment and/or prophylaxis of a nervous system disease, demyelinating disease and/or an inflammatory disease of either the central or peripheral nervous system. Leukemia inhibitory factor may be used alone or in combination with one or more other therapeutic molecules.

    摘要翻译： 本发明涉及用于治疗和/或预防神经系统疾病，脱髓鞘疾病和/或中枢神经系统或周围神经系统的炎性疾病的方法，例如但不限于脑病，甚至更特别地， 脑炎病情。 本发明还提供了白血病抑制因子或其衍生物，同系物或类似物在治疗和/或预防神经系统疾病，脱髓鞘疾病和/或中枢神经系统或周围神经系统的炎性疾病中的用途。 白血病抑制因子可以单独使用或与一种或多种其它治疗分子组合使用。