摘要:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要翻译:本发明涉及阿尔茨海默病的预防药物或补救剂,或淀粉样蛋白原纤维形成抑制剂,其包括作为活性成分的下列通式(I)的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药学上允许的盐,其作为阿尔茨海默病的预防剂或治疗药物是有价值的,或作为淀粉样蛋白原纤维形成抑制剂:(其中,R 1和R 2, Z 1和Z 2是H,烷基,烷氧基,卤代烷基或卤代; Z 3是烷氧基,SH,烷硫基,NH 2,一或二烷基氨基,OH或卤素; Z 4和Z 5是H或卤素; A是4,6-嘧啶-1,3-二基,1,3,5-三嗪-2,6-二基等)。
摘要:
Applied voltage to the contact charging sheet 71 has been controlled in the following various ways: a) the voltage at the photosensitive layer 10 at a point of time whereat it has passed the contact charging sheet 71 is caused to interlock with grid voltage so as not to exceed predetermined voltage to be electrified by the Scorotron charger 2; b) the applied voltage is caused to interlock with the output from the transfer unit 5 so that there is no portion which reaches the Scorotron charger 2 while the potential polarity has been reversed at the transfer unit 5; c) reduction in the film thickness of the photosensitive layer 10 is corrected in consideration of the cumulative number of sheets for image formation; d) the size of printing sheet is added; e) at the time of termination, a portion of the photosensitive layer 10, into which current has flowed at the transfer unit 5, is caused to stop always after passing the contact charging sheet 71; f) the contact charging sheet 71 is cleaned by means of AC component; and g) the applied voltage is switched while formation of an electrostatic latent image and the like are not performed. Thereby, the surface potential at the photosensitive drum 1 is prevented from becoming ununiform.
摘要:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要:
In an imaging cartridge for forming images at least including a corona charging device and an object to be charged, a discharging electrode unit in the corona charging device is supported in such a manner that the electrode unit can be separately detached therefrom and installed thereto without being obstructed by the object to be charged or by a grid electrode from a side opposite to the member to be charged.
摘要:
A charging device K is provided with a flexible electrode 12 and a flexible intermediate member M disposed between the flexible electrode 12 and a charge-receiving member 10, with the flexible intermediate member M being in contact with the charge-receiving member 10. The flexible intermediate member M includes a flexible insulated member 11 and semiconductive member 14 so as to charge the charge-receiving member 10 via a discharge from electrode 12. The absolute value of the difference between the potential of the flexible electrode 12 during discharge and the potential in the vicinity of at least the area of discharge of the flexible electrode 12 among areas in which the flexible intermediate member is in contact with the charge-receiving member 10, is less than the absolute value of the difference between the potential of the charge-receiving member and the potential of the flexible electrode during discharge.
摘要:
Grid wires arranged in an axial direction of a photoconductive drum have a positional relation with projecting electrodes arranged at regular intervals in an axial direction of the photoconductive drum at a position opposite to the surface of the photoconductive drum wherein the grid wires and the projecting electrodes positioned adjacent to each other are equally arranged in distance to uniformly discharge an electric charge to the surface of the photoconductive drum from each of the projecting electrodes so that uniform charging can be accomplished in an axial direction of the photoconductive drum.
摘要:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要:
Pharmaceutical compositions and methods of treatment are provided for treating amyloidosis, containing, as an active ingredient, at least one nitrogen-containing heteroaryl compound represented by the following general formula or a pharmacologically permitted salt thereof; together with nitrogen-containing heteroaryl derivatives, and pharmacologically permitted salts thereof: where, R1, R2, Z1-Z5, and A are as defined herein.
摘要:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要翻译:本发明涉及阿尔茨海默病的预防药物或补救剂,或淀粉样蛋白原纤维形成抑制剂,其包括作为活性成分的下列通式(I)的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药理学上允许的盐,其作为阿尔茨海默氏病的预防剂或治疗剂是有价值的,或作为淀粉样蛋白原纤维形成抑制剂:(其中R 1, 和R 2是H或烷基; Z 1和Z 2是H,烷基,烷氧基,卤代烷基或卤代; Z 3 烷氧基,SH,烷硫基,NH 2,单或二烷基氨基,OH或卤素; Z 4和Z 5 >为H或卤素; A为4,6-嘧啶-1,3-二基,1,3,5-三嗪-2,6-二基等)。
摘要:
This invention relates to the charging member portion of an image forming apparatus. A plurality of charging members are disclosed that maintain a uniform spacing between a charge-receiving member and the discharging portion of the charging members' electrodes despite surface irregularities and surface waviness on the charge-receiving member. One charging member is in the form of a flexible sheet provided with ventilation holes in a non-contacting portion thereof, permitting the air produced by the rotation of the charge-receiving member to escape through the holes to suppress the lifting of the charging member. Pressure fins can be added to the charging member on the downstream of the ventilation holes for further suppressing any lifting. Another charging member includes a semiconductive member or a electret member on at least the surface of the charging member on the side opposite the charge-receiving member. This permits the charging member to be electrostatically attracted to the charge-receiving member.