公开(公告)号：US09918951B2

公开(公告)日：2018-03-20

申请号：US12866001

申请日：2009-02-05

申请人： Yasushi Sakai ,  Shun Kayahashi

发明人： Yasushi Sakai ,  Shun Kayahashi

IPC分类号： A61K9/00 ,  A61K31/198 ,  A61K9/14 ,  A61K47/12 ,  A61K47/18 ,  A23L33/10 ,  A23L33/175

CPC分类号： A61K31/198 ,  A23L33/10 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/145 ,  A61K47/12 ,  A61K47/183 ,  A23V2200/02 ,  A23V2250/31 ,  A23V2250/0606 ,  A23V2250/063 ,  A23V2250/032 ,  A23V2250/056 ,  A23V2250/044 ,  A23V2250/708

摘要： The invention provides a method of improving the preservation stability of glutathione in a solid composition containing glutathione and arginine. In particular, glutathione and arginine are made to be coexistent with an organic acid such as citric acid, tartaric acid, ascorbic acid, malic acid, malonic acid, succinic acid, fumaric acid, maleic acid and the like. The amount of the organic acid to coexistent with glutathione and arginine is generally 0.1-2 parts by weight relative to 1 part by weight of arginine.

公开(公告)号：US08859807B2

公开(公告)日：2014-10-14

申请号：US12444298

申请日：2007-10-04

申请人： Yasushi Sakai ,  Aki Kato ,  Masao Kimura

发明人： Yasushi Sakai ,  Aki Kato ,  Masao Kimura

IPC分类号： C07C323/39 ,  A61K47/18 ,  A61K38/06

CPC分类号： A61K47/183 ,  A61K38/063

摘要： The present invention relates to a method of improving the preservation stability of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. In addition, the present invention relates to a production method of a glutathione preparation, which is characterized by mixing glutathione and an arginine-acidic amino acid salt. By the production method, a glutathione preparation that resists quality deterioration can be provided. Moreover, the present invention relates to a preservation method of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. By the preservation method, quality deterioration of glutathione during preservation can be suppressed.

摘要翻译： 本发明涉及一种提高谷胱甘肽保存稳定性的方法，其特征在于允许谷胱甘肽与精氨酸 - 酸性氨基酸盐共存。 此外，本发明涉及谷胱甘肽制剂的制备方法，其特征在于将谷胱甘肽和精氨酸 - 酸性氨基酸盐混合。 通过该制造方法，可以提供抗恶化的谷胱甘肽制剂。 此外，本发明涉及谷胱甘肽的保存方法，其特征在于允许谷胱甘肽与精氨酸 - 酸性氨基酸盐共存。 通过保存方法，可以抑制保存期间谷胱甘肽的质量恶化。

公开(公告)号：US20100255174A1

公开(公告)日：2010-10-07

申请号：US12743172

申请日：2008-11-17

申请人： Yasushi Sakai ,  Takeshi Ikeda ,  Ayako Kamimura

发明人： Yasushi Sakai ,  Takeshi Ikeda ,  Ayako Kamimura

IPC分类号： A23L2/52 ,  A23L2/42

CPC分类号： A61K47/12 ,  A23L2/52 ,  A23L2/68 ,  A23L33/175 ,  A61K31/198

摘要： The invention provides an easy-to-drink beverage that contains citrulline, wherein the generation of bad odors due to storage or heating is suppressed. In particular, the invention provides a beverage that contains citrulline and citric acid, as well as sodium citrate or disodium hydrogen phosphate.

摘要翻译： 本发明提供一种含有瓜氨酸的容易饮用饮料，其中抑制由储存或加热引起的不良气味的产生。 特别地，本发明提供含有瓜氨酸和柠檬酸以及柠檬酸钠或磷酸氢二钠的饮料。

公开(公告)号：US20090053798A1

公开(公告)日：2009-02-26

申请号：US11909391

申请日：2006-03-30

申请人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

发明人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

IPC分类号： C12N1/04 ,  A23L1/48

CPC分类号： C12N1/04

摘要： The present invention relates to a method of improving storage stability of dried microorganisms, such as dried lactic acid bacteria, by allowing the dried microorganisms to coexist with an L-arginine acidic amino acid salt, a composition comprising dried microorganisms and an L-arginine acidic amino acid salt and a process for producing the same, and a method of storing dried microorganisms in the presence of an L-arginine acidic amino acid salt. The storage stability of dried microorganisms can be improved by allowing the dried microorganisms to coexist with an L-arginine acidic amino acid salt.

摘要翻译： 本发明涉及通过使干燥的微生物与L-精氨酸酸性氨基酸盐共存，包含干燥的微生物的组合物和L-精氨酸的酸性化合物来提高干燥的微生物如干燥的乳酸菌的储存稳定性的方法 氨基酸盐及其制备方法，以及在L-精氨酸酸性氨基酸盐存在下储存干燥的微生物的方法。 通过使干燥的微生物与L-精氨酸酸性氨基酸盐共存，可以提高干燥微生物的储存稳定性。

公开(公告)号：US07404635B2

公开(公告)日：2008-07-29

申请号：US11802857

申请日：2007-05-25

申请人： Yasushi Sakai

发明人： Yasushi Sakai

IPC分类号： G02C1/02

CPC分类号： G02C1/02

摘要： A method is provided for securely holding a spectacle lens. Without using screwing members such as a screw and a nut, and extra parts such as a bush, a cylindrical pin and a slip-off preventive pin, a spectacle lens can surely be held. A taper pin is provided projecting on a lens holding member for holding a spectacle lens, and a taper hole having approximately the same size as the taper pin is provided on the spectacle lens. The taper pin is directly press-fitted into the taper hole, thereby holding the spectacle lens by a press-contact between an inner circumferential surface of the taper hole and an outer circumferential surface of the taper pin. The taper pin is press-fitted in a thickness direction of the spectacle lens.

摘要翻译： 提供了一种可靠地保持眼镜镜片的方法。 不使用诸如螺钉和螺母的螺纹构件，以及诸如衬套，圆柱销和防脱销的额外部件，可以可靠地保持眼镜镜片。 设置在用于保持眼镜片的透镜保持构件上突出的锥形销，并且在眼镜镜片上设置有与锥形销大致相同尺寸的锥形孔。 锥形销被直接压入锥形孔中，从而通过锥形孔的内周面和锥形销的外周面之间的压接而保持眼镜镜片。 锥形销在眼镜镜片的厚度方向上压配合。

公开(公告)号：US20080062583A1

公开(公告)日：2008-03-13

申请号：US11896486

申请日：2007-08-31

申请人： Shunji Takenoiri ,  Yasushi Sakai

发明人： Shunji Takenoiri ,  Yasushi Sakai

IPC分类号： G11B5/33

CPC分类号： G11B5/1278 ,  G11B5/65 ,  G11B5/66 ,  G11B5/7325

摘要： A perpendicular magnetic recording medium composed of a nonmagnetic substrate having a surface onto which are provided a plurality of layers including, in the order recited, a soft underlayer; a nonmagnetic coupling layer; a hard magnetic pinning layer which is antiferromagnetically coupled to the soft underlayer at ambient temperature via the nonmagnetic coupling layer and which has an axis of easy magnetization which extends in a direction which is perpendicular to that of the surface of the nonmagnetic substrate; a nonmagnetic intermediate layer; and a magnetic recording layer. Such a perpendicular magnetic recording medium has an improved medium performance, with reduced noise originating from the presence of the soft underlayer, and no erasure of recorded magnetization when influenced by an external magnetic field.

摘要翻译： 由具有表面的非磁性基板构成的垂直磁记录介质设置有多个层，所述多个层按顺序包括柔性底层; 非磁耦合层; 硬磁性钉扎层，其在环境温度下通过非磁性耦合层反铁磁耦合到软底层，并且具有沿与垂直于非磁性基底的表面垂直的方向延伸的易磁化轴; 非磁性中间层; 和磁记录层。 这样的垂直磁记录介质具有改进的介质性能，具有源于软底层的存在的降低的噪声，并且在被外部磁场影响时不会擦除记录的磁化。

公开(公告)号：US07332522B2

公开(公告)日：2008-02-19

申请号：US10473867

申请日：2002-03-28

申请人： Yasushi Sakai ,  Shun Kayahashi ,  Erika Hashizume ,  Ryusuke Nakagiri

发明人： Yasushi Sakai ,  Shun Kayahashi ,  Erika Hashizume ,  Ryusuke Nakagiri

IPC分类号： A61K31/34 ,  A61K31/343

CPC分类号： A61K31/365 ,  A23L33/10 ,  A61K31/366 ,  C07D307/88 ,  C07D311/76

摘要： A liver function protecting or improving agent which comprises a compound represented by the formula (I) {in the formula (I), R1, R2, R3, R4, R5, R6, R7, R8 and R9 may be the same or different, and represent hydrogen, halogen, hydroxy, alkoxy or alkyl; and RA represents the formula (II) [in the formula (II), R10 and R11 may be the same or different, and represent hydrogen or halogen, or R10 and R11 together represent a binding] or the formula (III) [in the formula (III), R12 represents hydrogen, halogen, hydroxy, alkoxy, cyano or alkyl, R13 and R14 may be the same or different, and represent hydrogen or halogen, or R13 and R14 together represent a binding]} or a glycoside thereof or a pharmaceutically acceptable salt thereof.

摘要翻译： 一种肝功能保护或改善剂，其包含由式（I）表示的化合物（在式（I）中，R 1，R 2，R 2，R 2， R 4，R 4，R 5，R 6，R 7，R 7， 8和R 9可以相同或不同，表示氢，卤素，羟基，烷氧基或烷基; 并且R A表示式（II）[在式（II）中，R 10和R 11可以相同或不同， 并且表示氢或卤素，或者R 10和R 11一起代表结合]或式（III）[在式（III）中，R 12 代表氢，卤素，羟基，烷氧基，氰基或烷基，R 13和R 14可以相同或不同，表示氢或卤素，或 R 13和R 14一起代表其结合的}}或其糖苷或其药学上可接受的盐。

公开(公告)号：US20060258746A1

公开(公告)日：2006-11-16

申请号：US11272107

申请日：2005-11-08

申请人： Toshikazu Kamiya ,  Takeshi Shibasaki ,  Asuka Otofuji ,  Yasushi Sakai ,  Akemi Ogawa ,  Miho Komatsu

发明人： Toshikazu Kamiya ,  Takeshi Shibasaki ,  Asuka Otofuji ,  Yasushi Sakai ,  Akemi Ogawa ,  Miho Komatsu

IPC分类号： A61K31/198

CPC分类号： A61K31/198

摘要： A person, who has symptoms including difficulty in going to sleep, feeling languid after waked up or having a hard time awaking, is desirous of a medicament and a nutritional food that can alleviate the symptoms and improve his or her health. Specifically, one object of the present invention is to provide an orally administered agent, a food and drink, or a food additive which can be used for improving the process of going to sleep and waking. An orally administered agent, a food and drink, or a food additive for improving the process of going to sleep and waking, containing ornithine or a salt thereof as an active ingredient can be provided according to the present invention.

摘要翻译： 患有睡眠困难，睡眠觉醒或醒来困难等症状的人，希望能够减轻症状，改善身体健康的药物和营养食品。 具体地说，本发明的一个目的是提供可用于改善睡眠和醒来过程的口服制剂，食品和饮料或食品添加剂。 根据本发明，可以提供含有鸟氨酸或其盐作为活性成分的口服给药剂，食品饮料或用于改善睡眠和醒来过程的食品添加剂。

公开(公告)号：US06863951B2

公开(公告)日：2005-03-08

申请号：US10626525

申请日：2003-07-25

申请人： Yasushi Sakai

发明人： Yasushi Sakai

IPC分类号： H01H13/14 ,  H01H11/00 ,  H01H13/02 ,  H01H13/702 ,  B32B3/24 ,  B29C45/14 ,  H01H1/10

CPC分类号： H01H13/702 ,  H01H2227/036 ,  H01H2229/047 ,  Y10T428/24273 ,  Y10T428/24281 ,  Y10T428/24289 ,  Y10T428/24339

摘要： Disclosed is a film key sheet with a key top protruding from a resin film which allows a further reduction in thickness and provides a sufficient degree of clarity in visually recognizing a display portion thereof, and a method for manufacturing such a film key sheet. The film key sheet has a film removal hole piercing through the resin film, with a hole edge portion raised from the surface of the resin film being secured to the side surface of the key top. Thus, no resin film exists on the upper and bottom surfaces of the key top, so that it is possible to achieve a further reduction in thickness independently of the foldability of the resin film and drawing accuracy and to provide clarity in visual recognition of a display portion at the bottom of the key top.

摘要翻译： 公开了一种具有从树脂膜突出的键顶的胶片键盘，其允许进一步减小厚度并且在视觉上识别其显示部分时提供足够的清晰度，以及制造这种胶片键盘的方法。 胶片按键板具有穿过树脂膜的膜去除孔，从树脂膜的表面凸出的孔边缘部固定在键顶的侧面。 因此，在键顶的上表面和下表面上不存在树脂膜，从而可以独立于树脂膜的折叠性和拉伸精度而进一步降低厚度，并且提供显示器的视觉识别的清晰度 部分在键顶的底部。

公开(公告)号：US20050037238A1

公开(公告)日：2005-02-17

申请号：US10934555

申请日：2004-09-07

申请人： Yasushi Sakai ,  Akihiro Ohtsuki ,  Keiji Ohkubo ,  Kazuo Enomoto ,  Sadayuki Watanabe ,  Takahiko Tamaki ,  Kiyoshi Kuga ,  Eiichi Miyashita ,  Ryo Taguchi

发明人： Yasushi Sakai ,  Akihiro Ohtsuki ,  Keiji Ohkubo ,  Kazuo Enomoto ,  Sadayuki Watanabe ,  Takahiko Tamaki ,  Kiyoshi Kuga ,  Eiichi Miyashita ,  Ryo Taguchi

IPC分类号： C23C14/14 ,  C23C14/34 ,  G11B5/64 ,  G11B5/667 ,  G11B5/73 ,  G11B5/851 ,  H01F10/13 ,  H01F41/18 ,  B05D5/12 ,  B05D1/36 ,  B05D3/08

CPC分类号： G11B5/667 ,  G11B5/7325 ,  G11B5/851

摘要： The present invention provides a method for easily obtaining a perpendicular magnetic recording medium having the desired magnetic properties by sputtering, and a magnetic recording medium obtained by this method. The perpendicular magnetic recording medium of the present invention is a perpendicular magnetic recording medium comprising at least a soft magnetic underlayer, an underlayer, a magnetic recording layer, a protective layer, and a liquid lubricant layer sequentially laminated on a nonmagnetic substrate, wherein the magnetic recording layer is a rare earth-transition metal alloy amorphous film formed by sputtering, and the formation of the magnetic recording layer by sputtering is performed using a film-forming gas incorporating 2% or more, but 60% or less of an H2 gas. The present invention also discloses a method for producing the perpendicular magnetic recording medium.

摘要翻译： 本发明提供一种通过溅射容易地获得具有所需磁特性的垂直磁记录介质的方法和通过该方法获得的磁记录介质。 本发明的垂直磁记录介质是至少包括依次层压在非磁性基板上的软磁性底层，底层，磁记录层，保护层和液体润滑剂层的垂直磁记录介质，其中磁性 记录层是通过溅射形成的稀土 - 过渡金属合金非晶膜，并且通过溅射形成磁记录层是使用包含2％以上但60％以下的H 2气的成膜气体进行的。 本发明还公开了一种垂直磁记录介质的制造方法。