公开(公告)号：US08993543B2

公开(公告)日：2015-03-31

申请号：US13883847

申请日：2011-12-20

申请人： Kumi Ishikawa ,  Shigeru Koga ,  Yasushi Kohno ,  Kiyoshi Fujii ,  Ken Yoshikawa

发明人： Kumi Ishikawa ,  Shigeru Koga ,  Yasushi Kohno ,  Kiyoshi Fujii ,  Ken Yoshikawa

IPC分类号： C07F9/38 ,  C07F9/09 ,  C07F9/40

CPC分类号： C07F9/38 ,  C07F9/091 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/4015

摘要： [Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity.[Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.

摘要翻译： [问题]提供可用作具有优异的S1P3拮抗剂活性的药物的二苯硫醚衍生物。 发明人已经发现，通式（1）表示的二苯硫醚衍生物（其中，R1表示碳原子数1〜6的烷氧基，R2表示丙基或烯丙基，X表示亚甲基或氧原子 ，Z表示卤素原子）作为具有S1P3拮抗剂活性的化合物的生产的广泛研究的结果，具有优异的S1P3拮抗剂活性。

公开(公告)号：US08701475B2

公开(公告)日：2014-04-22

申请号：US13568481

申请日：2012-08-07

申请人： Yasushi Kohno

发明人： Yasushi Kohno

IPC分类号： G01M15/04

CPC分类号： G01F1/684 ,  G01F1/6842 ,  G01F5/00

摘要： An air flow measuring device includes a housing, flow sensor, and a humidity sensor. The housing defines a bypass flow passage through which intake it passes. A part of intake air is taken into the bypass flow passage to pass through the bypass flow passage. The flow sensor includes a sensing part disposed in the bypass flow passage, and produces a signal which is in accordance with the flow rate of intake air as a result of heat transfer between intake air taken into the bypass flow passage and the sensing part. The humidity sensor includes a sensing part exposed to the intake passage, and projects from an outer wall of the housing into the intake passage. The humidity sensor produces a signal which is in accordance with humidity of intake ail flowing through the intake passage.

摘要翻译： 气流测量装置包括壳体，流量传感器和湿度传感器。 外壳限定了一个旁路流通道，通过该通道进入它。 进气的一部分被吸入旁通流路以通过旁通流路。 流量传感器包括设置在旁通流路中的感测部，并且产生与进入旁通流路的吸入空气和感测部之间的热传递结果相对应的进气流量的信号。 湿度传感器包括暴露于进气通道的感测部分，并且从外壳的外壁突出到进气通道中。 湿度传感器产生的信号与进气通道中的进气通道的湿度相一致。

公开(公告)号：US20140018335A1

公开(公告)日：2014-01-16

申请号：US13980599

申请日：2012-01-24

申请人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

发明人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

IPC分类号： C07D209/08 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C07D405/14 ,  C07D405/06 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/40 ,  C07D417/14 ,  A61K31/444 ,  C07D401/06 ,  C07D409/14

CPC分类号： C07D209/08 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K45/06 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K2300/00

摘要： The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a pyridine ring, a furan ring, or the like; Y1 represents a C1-6 alkylene group; Y2 represents a single bond or the like; R1 represents —C(═O)—NH—SO2R6, an acidic 5-membered hetero ring group, or the like; R2 represents an optionally substituted phenyl group, an optionally substituted 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], and a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.

摘要翻译： 本发明提供了具有EP1受体拮抗作用的本发明通式（I）表示的化合物：其中A表示吡啶环，呋喃环等; Y1表示C1-6亚烷基; Y2表示单键等; R 1表示-C（= O）-NH-SO 2 R 6，酸性5元杂环基等; R 2表示任选取代的苯基，任选取代的5元芳族杂环基等; R3表示卤素原子，C1-6烷氧基等; R 4表示氢原子，卤素原子等; R5表示氢原子等; 和R6表示C1-6烷基等〕及其药学上可接受的盐。 此外，本发明的化合物（I）可以用作治疗或预防LUTS，特别是OAB的各种症状的药剂。

公开(公告)号：US08476261B2

公开(公告)日：2013-07-02

申请号：US12678120

申请日：2008-09-12

申请人： Oana Cociorva ,  Yasumichi Fukuda ,  Yasushi Kohno ,  Bei Li ,  Kyoko Okada ,  Ayako Nakamura ,  Masahiro Nomura ,  Shigeki Seto ,  Anna Katrin Szardenings ,  Kazuhiro Yumoto

发明人： Oana Cociorva ,  Yasumichi Fukuda ,  Yasushi Kohno ,  Bei Li ,  Kyoko Okada ,  Ayako Nakamura ,  Masahiro Nomura ,  Shigeki Seto ,  Anna Katrin Szardenings ,  Kazuhiro Yumoto

IPC分类号： A61K31/5386

CPC分类号： C07D498/06 ,  A61J1/00 ,  C07D498/10 ,  C07D498/20

摘要： Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases. In Formula (I): X1 is O or NR8; A is bond or substituted or unsubstituted C1-C2 alkylene, wherein the substituents when present are selected from one to four Q2 groups; where Q2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2.

摘要翻译： 本文提供式I的螺环氨基喹诺酮和含有该化合物的组合物。 本文提供的化合物和组合物可用于预防，改善或治疗GSK-3抑制剂介导的疾病。 式（I）中，X 1为O或NR 8; A是键或取代或未取代的C 1 -C 2亚烷基，其中当存在时的取代基选自1至4个Q 2基团; 其中Q2是烷基或卤代烷基; p为0或1; q为0〜2的整数。

公开(公告)号：US20130036806A1

公开(公告)日：2013-02-14

申请号：US13568481

申请日：2012-08-07

申请人： Yasushi KOHNO

发明人： Yasushi KOHNO

IPC分类号： G01M15/04

CPC分类号： G01F1/684 ,  G01F1/6842 ,  G01F5/00

摘要： An air flow measuring device includes a housing, flow sensor, and a humidity sensor. The housing defines a bypass flow passage through which intake it passes. A part of intake air is taken into the bypass flow passage to pass through the bypass flow passage. The flow sensor includes a sensing part disposed in the bypass flow passage, and produces a signal which is in accordance with the flow rate of intake air as a result of heat transfer between intake air taken into the bypass flow passage and the sensing part. The humidity sensor includes a sensing part exposed to the intake passage, and projects from an outer wall of the housing into the intake passage. The humidity sensor produces a signal which is in accordance with humidity of intake ail flowing through the intake passage.

摘要翻译： 气流测量装置包括壳体，流量传感器和湿度传感器。 外壳限定了一个旁路流通道，通过该通道进入它。 进气的一部分被吸入旁通流路以通过旁通流路。 流量传感器包括设置在旁通流路中的感测部，并且产生与进入旁通流路的吸入空气和感测部之间的热传递结果相对应的进气流量的信号。 湿度传感器包括暴露于进气通道的感测部分，并且从外壳的外壁突出到进气通道中。 湿度传感器产生的信号与进气通道中的进气通道的湿度相一致。

公开(公告)号：US20120247202A1

公开(公告)日：2012-10-04

申请号：US13438148

申请日：2012-04-03

申请人： Yasushi KOHNO ,  Hiromi Ariyoshi

发明人： Yasushi KOHNO ,  Hiromi Ariyoshi

IPC分类号： G01F1/69

CPC分类号： G01F1/699 ,  G01F1/6842

摘要： A thermal type air flow meter, which detects a flow rate of air flowing in an air passage, includes a sensor portion having a heating element in an air passage, a temperature control unit. The temperature control unit includes a first arm serially connecting a first resistive element and a heater temperature detection resistor which detects a temperature of the heating element, a second arm serially connecting a second resistive element and an air temperature detection resistor which detects a temperature of air flowing in the air passage, and a voltage supply unit which supplies first and second voltages respectively to the first and second arms. The voltage supply unit includes a voltage adjusting portion which can adjust at least one of the first and second voltages such that the detection temperature difference between the heater temperature detection resistor and the air temperature detection resistor becomes constant.

摘要翻译： 检测在空气通道中流动的空气的流量的热式空气流量计包括在空气通道中具有加热元件的传感器部分，温度控制单元。 温度控制单元包括串联连接第一电阻元件和检测加热元件的温度的加热器温度检测电阻器的第一臂，串联连接第二电阻元件的第二臂和检测空气温度的空气温度检测电阻器 在空气通道中流动;以及电压供应单元，其分别向第一和第二臂提供第一和第二电压。 电压供给单元包括电压调整部，其能够调整第一和第二电压中的至少一个，使得加热器温度检测电阻和空气温度检测电阻之间的检测温度差变为恒定。

公开(公告)号：US20120240668A1

公开(公告)日：2012-09-27

申请号：US13412644

申请日：2012-03-06

申请人： Yasushi GOKA ,  Yasushi Kohno ,  Takashi Ooga

发明人： Yasushi GOKA ,  Yasushi Kohno ,  Takashi Ooga

IPC分类号： G01M15/04

CPC分类号： G01F1/6842 ,  G01F1/72 ,  G01F5/00

摘要： An air flow measurement device arranged in an intake passage includes a bypass passage having an inlet from which a part of a main flow of an intake air is introduced, and an outlet from which the introduced intake air flows out. A sensor is located in the bypass passage to generate an electrical signal, and the bypass passage communicates with the intake passage through a hole portion. The outlet is open toward a downstream side of the intake passage in a flow direction of the main flow of the intake air. The hole portion is located within an outlet projected area that is provided by projecting an open area of the outlet in straight and toward upstream in the flow direction of the main flow on a projection surface perpendicular to the flow direction of the main flow.

摘要翻译： 布置在进气通道中的气流测量装置包括旁通通道，其具有引入进气的主流的一部分的入口和引入的进气的出口。 传感器位于旁路通道中以产生电信号，并且旁路通道通过孔部与进气通道连通。 出口在进气主流的流动方向上朝向进气通道的下游侧开口。 孔部位于通过在垂直于主流的流动方向的突出表面上在主流的流动方向上以直线向上游突出的出口的开口区域而设置的出口突出区域。

公开(公告)号：US20120101745A1

公开(公告)日：2012-04-26

申请号：US13280625

申请日：2011-10-25

申请人： Yasushi Kohno ,  Takao Ban ,  Akitoshi Mizutani

发明人： Yasushi Kohno ,  Takao Ban ,  Akitoshi Mizutani

IPC分类号： G06F19/00

CPC分类号： F02D41/18 ,  F02D41/28 ,  F02D2041/286 ,  F02D2041/288 ,  G01F1/6842 ,  G01F1/696 ,  G01F1/72

摘要： A flow measuring device includes a flow rate detecting part, an analog/digital conversion part, and a signal processing part. The flow rate detecting part detects a flow rate of air flowing through the passage, and outputs a flow voltage signal, which is a voltage in accordance with the flow rate. The analog/digital conversion part converts the flow voltage signal from the flow rate detecting part into digital data, which is flow digital data. The signal processing part performs calculation processing upon the flow digital data, which includes averaging of a predetermined number of consecutive pieces of the flow digital data, and outputs the averaged flow digital data as a flow rate signal. The predetermined number is equal to or larger than two.

摘要翻译： 流量测量装置包括流量检测部分，模拟/数字转换部分和信号处理部分。 流量检测部检测流过通路的空气的流量，并输出作为与流量对应的电压的流量电压信号。 模拟/数字转换部分将来自流量检测部分的流量电压信号转换成数字数据，这是流量数字数据。 信号处理部分对流数字数据执行计算处理，其包括预定数量的连续的流数字数据的平均值，并将平均流量数字数据作为流量信号输出。 预定数量等于或大于2。

公开(公告)号：US20120085163A1

公开(公告)日：2012-04-12

申请号：US13242130

申请日：2011-09-23

申请人： Junzo Yamaguchi ,  Yasushi Kohno

发明人： Junzo Yamaguchi ,  Yasushi Kohno

IPC分类号： G01F1/69

CPC分类号： G01F1/00

摘要： A first conductive line, through which a midpoint electric potential of a first series circuit of a bridge circuit is outputted, is branched from a first midpoint connection on a sensor chip. A second conductive line, through which a midpoint electric potential of a second series circuit of the bridge circuit is outputted, is branched from a second midpoint connection on the sensor chip. The output point of the midpoint electric potential of the first series circuit is provided at a midpoint between two temperature sensor resistors, and the first midpoint connection is provided on a center line of a heater resistor. The output point of the midpoint electric potential of the second series circuit is provided at a midpoint between two temperature sensor resistors, and the second midpoint connection is provided on the center line of the heater resistor.

摘要翻译： 输出桥接电路的第一串联电路的中点电位的第一导线从传感器芯片上的第一中点连接分支。 输出桥电路的第二串联电路的中点电位的第二导线从传感器芯片上的第二中点连接分支。 第一串联电路的中点电位的输出点设置在两个温度传感器电阻之间的中点处，并且第一中点连接设置在加热电阻器的中心线上。 第二串联电路的中点电位的输出点设置在两个温度传感器电阻之间的中点处，第二中点连接设置在加热电阻器的中心线上。

公开(公告)号：US20110233923A1

公开(公告)日：2011-09-29

申请号：US13073744

申请日：2011-03-28

申请人： Masayuki KOUKETSU ,  Hiroshi ITAFUJI ,  Shinji HAYAKAWA ,  Yasushi KOHNO

发明人： Masayuki KOUKETSU ,  Hiroshi ITAFUJI ,  Shinji HAYAKAWA ,  Yasushi KOHNO

IPC分类号： F16L39/00 ,  F16L9/18

CPC分类号： F16L59/065 ,  F16L39/005 ,  F16L59/182 ,  H01L21/67017

摘要： This invention provides a connected structure of vacuum double pipes. The connected structure comprises a plurality of vacuum double pipes and a joint configured to connect the plurality of vacuum double pipes. The vacuum passage is open at both end in an extension direction of the inner pipe and sealed between the both ends. The joint includes an inner pipe joint unit having inner pipe connectors and an outer pipe joint unit having outer pipe connectors. The evacuation passage is sealed between the outer pipe connectors that connect the vacuum passages of the outer pipes.

摘要翻译： 本发明提供真空双管的连接结构。 连接结构包括多个真空双管和连接多个真空双管的接头。 真空通道在内管的延伸方向的两端开口，并在两端之间密封。 接头包括具有内管连接器的内管接头单元和具有外管连接器的外管接头单元。 在连接外管的真空通道的外管连接器之间密封排气通道。