公开(公告)号：US09134290B2

公开(公告)日：2015-09-15

申请号：US13640312

申请日：2011-04-14

Applicant: Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

Inventor： Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

IPC: G01N33/18 ,  G01N33/00 ,  G01N21/75 ,  G01N21/00

CPC classification number: G01N21/78 ,  G01N21/75 ,  G01N33/18 ,  G01N33/1826 ,  Y10T436/19 ,  Y10T436/193333

Abstract: A real-time, on-line method and analytical system for determining halohydrocarbons in water which operate by (1) extracting on-line samples; (2) purging volatile halohydrocarbons from the water (e.g., with air or nitrogen); (3) carrying the purge gas containing the analytes of interest over a porous surface where the analytes are adsorbed; (4) recovering the analytes from the porous surface with heat (thermal desorption) or solvent (solvent elution) to drive the analytes into an organic chemical mixture; (5) generating an optical change (e.g., color change) in dependence upon a reaction involving the analytes and a pyridine derivative; and (6) measuring optical characteristics associated with the reaction to quantify the volatile halogenated hydrocarbon concentration.

Abstract translation: 一种用于测定水中卤代烃的实时在线方法和分析系统，其操作为（1）提取在线样品; （2）从水中（例如用空气或氮气）吹扫挥发性卤代烃; （3）在分析物被吸附的多孔表面上携带含有感兴趣分析物的吹扫气体; （4）用热（热解吸）或溶剂（溶剂洗脱）从多孔表面回收分析物，以将分析物驱使到有机化学混合物中; （5）根据涉及分析物的反应和吡啶衍生物产生光学变化（例如，颜色变化）; 和（6）测量与反应相关的光学特性以量化挥发性卤代烃浓度。

公开(公告)号：US20130029427A1

公开(公告)日：2013-01-31

申请号：US13640312

申请日：2011-04-14

Applicant: Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

Inventor： Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

IPC: G01N21/75

CPC classification number: G01N21/78 ,  G01N21/75 ,  G01N33/18 ,  G01N33/1826 ,  Y10T436/19 ,  Y10T436/193333

Abstract: A real-time, on-line method and analytical system for determining halohydrocarbons in water which operate by (1) extracting on-line samples; (2) purging volatile halohydrocarbons from the water (e.g., with air or nitrogen); (3) carrying the purge gas containing the analytes of interest over a porous surface where the analytes are adsorbed; (4) recovering the analytes from the porous surface with heat (thermal desorption) or solvent (solvent elution) to drive the analytes into an organic chemical mixture; (5) generating an optical change (e.g., color change) in dependence upon a reaction involving the analytes and a pyridine derivative; and (6) measuring optical characteristics associated with the reaction to quantify the volatile halogenated hydrocarbon concentration.

Abstract translation: 一种用于测定水中卤代烃的实时在线方法和分析系统，其操作为（1）提取在线样品; （2）从水中（例如用空气或氮气）吹扫挥发性卤代烃; （3）在分析物被吸附的多孔表面上携带含有感兴趣分析物的吹扫气体; （4）用热（热解吸）或溶剂（溶剂洗脱）从多孔表面回收分析物，以将分析物驱动到有机化学混合物中; （5）根据涉及分析物的反应和吡啶衍生物产生光学变化（例如，颜色变化）; 和（6）测量与反应相关的光学特性以量化挥发性卤代烃浓度。

公开(公告)号：US07358486B1

公开(公告)日：2008-04-15

申请号：US11323081

申请日：2005-12-30

Applicant: Ye Han

Inventor： Ye Han

IPC: H01J49/04

CPC classification number: H01J49/165 ,  H01J49/0031

Abstract: A method, system, and mixture for simultaneously cleaning and reconditioning at least a part of a sampling pathway of an inline automated mass spectrometry system are disclosed. A sampling pathway including a probe or a nebulizer, in one example, may be simultaneously reconditioned and cleaned by mixing an isotopically enriched species and/or natural abundant species with a cleaning solution, and then cleaning the sampling pathway with the spiked cleaning solution through various means and procedures.

Abstract translation: 公开了用于同时清洁和修复在线自动化质谱系统的至少一部分取样通道的方法，系统和混合物。 在一个实例中，包括探针或雾化器的采样路径可以通过将同位素富集的物种和/或天然丰富物质与清洁溶液混合，同时进行再生和清洁，然后通过各种方法用加标清洗溶液清洗取样通道 手段和程序。

公开(公告)号：US07335877B1

公开(公告)日：2008-02-26

申请号：US11323080

申请日：2005-12-30

Applicant: Ye Han ,  Yuzhong Wang ,  Wenjing Yang

Inventor： Ye Han ,  Yuzhong Wang ,  Wenjing Yang

IPC: H01J49/04

CPC classification number: H01J49/165

Abstract: An apparatus and method for improved inline and automated chemical analysis is provided, in particular disclosing signal optimization for an electrospray ionization mass spectrometer apparatus. A substantially inert pathway for ion analysis is provided by using substantially inert metals or polymers for pathway parts. Other enhancements and advantages are also disclosed, including an advantageous probe profile and metal foil cover.

Abstract translation: 提供了用于改进在线和自动化学分析的装置和方法，特别是公开了电喷雾离子化质谱仪装置的信号优化。 通过使用基本惰性的金属或聚合物作为通路部分，提供了用于离子分析的基本惰性的途径。 还公开了其它增强和优点，包括有利的探针轮廓和金属箔盖。

公开(公告)号：US20060097144A1

公开(公告)日：2006-05-11

申请号：US11301476

申请日：2005-12-12

Applicant: Howard Kingston ,  Marc Anderson ,  Ye Han

Inventor： Howard Kingston ,  Marc Anderson ,  Ye Han

IPC: B01D59/44

CPC classification number: H01J49/0031 ,  H01J49/0009 ,  H01J49/04

Abstract: In one embodiment, a method of analysis of a solution is provided including the acts of: (a) mixing a spike with a sample of the solution to allow equilibrium to occur therebetween; (b) ionizing the equilibrated diluted sample and spike in an atmospheric pressure ionizer (API) to produce ions; (c) processing the ions in a mass spectrometer to provide a ratio response; (d) characterizing the concentration of a constituent in the sample using the ratio response; and (e) cyclically repeating acts (a) through (d) under machine control to automatically monitor the concentration of the constituent in the solution over time.

Abstract translation: 在一个实施例中，提供了一种解决方案的分析方法，其包括以下动作：（a）将尖峰与溶液样品混合以使它们之间发生平衡; （b）将平衡的稀释样品和大气压离子发生器（API）中的尖峰电离以产生离子; （c）在质谱仪中处理离子以提供比例响应; （d）使用比率响应来表征样品中成分的浓度; 和（e）在机器控制下循环重复动作（a）至（d），以便随时间自动监测溶液中成分的浓度。