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公开(公告)号：US06649755B1
公开(公告)日：2003-11-18
申请号：US10111636
申请日：2002-04-26
IPC分类号： C07H506
CPC分类号： C07H15/203
摘要： Disclosed herein is a process for preparing highly pure acarbose of formula (I) useful as medicine for the treatment of diabetes. The disclosed process comprises prepurifying an acarbose-containing solution using a synthetic adsorbent to produce a prepurified acarbose having an acarbose content of a predetermined level or more; and contacting the prepurified acarbose with a monodispersed, strongly acid cation exchanger, in one step, to absorb acarbose.
摘要翻译： 本文公开了一种制备用作治疗糖尿病药物的式（I）的高纯度阿卡波糖的方法。 所公开的方法包括使用合成吸附剂对含阿卡波糖的溶液进行预净化以产生具有预定水平或更高水平的阿卡波糖含量的预纯化阿卡波糖; 并在一个步骤中将预纯化的阿卡波糖与单分散的强酸阳离子交换剂接触以吸收阿卡波糖。
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公开(公告)号：US07405267B2
公开(公告)日：2008-07-29
申请号：US10621353
申请日：2003-07-18
申请人： Tae-Won Kang , Byoung-Taek Choi , Gang-Sun Choi , Yong-Rack Choi , Sung-Ho Hwang
发明人： Tae-Won Kang , Byoung-Taek Choi , Gang-Sun Choi , Yong-Rack Choi , Sung-Ho Hwang
CPC分类号： C07K9/008
摘要： Disclosed is a method for purifying teicoplanin A2 comprising: (i) a primary pre-purification step of purifying a filtrate of fermentation broth of a strain using a synthetic adsorbent; (ii) a secondary pre-purification step of purifying the primary pre-purification solution using a cation exchange resin having a high cross-linkage, a catalytic resin or a chelate resin; (iii) a final purification step of purifying the secondary pre-purification solution using a reversed phase resin; and (iv) a powder-forming step. According to the present invention, it is possible to obtain teicoplanin A2 with a higher purity through a relatively simple process without using an excessive amount of an organic solvent.
摘要翻译： 公开了一种纯化泰可菌素A 2 O 2的方法，其包括：（i）使用合成吸附剂纯化菌株发酵液的滤液的初级预纯化步骤; （ii）使用具有高交联键的阳离子交换树脂，催化树脂或螯合树脂来纯化所述初级预纯化溶液的二次预纯化步骤; （iii）使用反相树脂纯化二次预纯化溶液的最终纯化步骤; 和（iv）粉末形成步骤。 根据本发明，可以通过相对简单的方法获得具有较高纯度的替考拉宁A 2 N 2，而不使用过量的有机溶剂。
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