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公开(公告)号:US5874572A
公开(公告)日:1999-02-23
申请号:US817205
申请日:1997-06-16
申请人: Jung Woo Kim , Nam Hee Choi , Sang Chul Lee , Gang Sun Choi , Yun Beom Ham , Don Wha Lee , Kyeong Bok Min
发明人: Jung Woo Kim , Nam Hee Choi , Sang Chul Lee , Gang Sun Choi , Yun Beom Ham , Don Wha Lee , Kyeong Bok Min
IPC分类号: C12P35/06 , A61K38/00 , A61P37/06 , C07K1/14 , C07K1/16 , C07K7/64 , C12P21/04 , C12R1/645 , C07D257/00 , C07D259/00
CPC分类号: C07K7/645
摘要: A process for the isolation of cyclosporin A comprising the steps of: adding a lower alkanol solvent to a culture fluid of a mutant of Tolypocladium inflatum to form a mixture, filtering the mixture to form an extract, transferring the extract to methylene chloride as a solvent therefor, and column chromatographing the resultant product on silica gel.
摘要翻译: PCT No.PCT / KR95 / 00095 Sec。 371日期:1997年6月16日 102(e)日期1997年6月16日PCT提交1995年7月31日PCT公布。 公开号WO96 / 12031 日期1996年04月25日一种分离环孢菌素A的方法,包括以下步骤:将低级链烷醇溶剂加入到致炎球菌突变体的培养液中以形成混合物,过滤混合物以形成提取物,将提取物转移至 二氯甲烷作为溶剂,并将所得产物在硅胶上进行色谱分离。
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公开(公告)号:US5734048A
公开(公告)日:1998-03-31
申请号:US554699
申请日:1995-11-07
申请人: Jung Woo Kim , Nam Hee Choi , Gang Sun Choi , Don Wha Lee
发明人: Jung Woo Kim , Nam Hee Choi , Gang Sun Choi , Don Wha Lee
IPC分类号: C07D498/02 , C07D503/00 , C07D503/18 , A61K31/42
CPC分类号: C07D503/00
摘要: According to the present invention, a process for manufacturing alkali metal salt of clavulanic acid wherein impure clavulanic acid in aqueous solution is extracted by a solvent mixture of ketone and alkyl acetate under acidic condition, treated in a conventional manner, and a solution of alkali metal salt of alkanoic acid dissolved in ketone or alkanol solvent is added to obtain pure alkali metal salt of clavulanic acid is provided. Since the process according to the present invention omits a step of formation of amine salt, an economic and simple method for manufacturing alkali metal salt of clavulanic acid in a high yield without excessive use of solvent is provided.
摘要翻译: 根据本发明,在酸性条件下,用常规方法处理的酮和烷基乙酸酯的溶剂混合物提取其中不溶的克拉维酸在水溶液中的不溶性克拉维酸的制备方法和碱金属盐溶液 加入溶解在酮或链烷醇溶剂中的链烷酸盐,得到纯碱的克拉维酸碱金属盐。 由于根据本发明的方法省略了形成胺盐的步骤,因此提供了一种经济且简单的以高产率制备克拉维酸碱金属盐而不过度使用溶剂的方法。
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公开(公告)号:US06649755B1
公开(公告)日:2003-11-18
申请号:US10111636
申请日:2002-04-26
IPC分类号: C07H506
CPC分类号: C07H15/203
摘要: Disclosed herein is a process for preparing highly pure acarbose of formula (I) useful as medicine for the treatment of diabetes. The disclosed process comprises prepurifying an acarbose-containing solution using a synthetic adsorbent to produce a prepurified acarbose having an acarbose content of a predetermined level or more; and contacting the prepurified acarbose with a monodispersed, strongly acid cation exchanger, in one step, to absorb acarbose.
摘要翻译: 本文公开了一种制备用作治疗糖尿病药物的式(I)的高纯度阿卡波糖的方法。 所公开的方法包括使用合成吸附剂对含阿卡波糖的溶液进行预净化以产生具有预定水平或更高水平的阿卡波糖含量的预纯化阿卡波糖; 并在一个步骤中将预纯化的阿卡波糖与单分散的强酸阳离子交换剂接触以吸收阿卡波糖。
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公开(公告)号:US07405267B2
公开(公告)日:2008-07-29
申请号:US10621353
申请日:2003-07-18
申请人: Tae-Won Kang , Byoung-Taek Choi , Gang-Sun Choi , Yong-Rack Choi , Sung-Ho Hwang
发明人: Tae-Won Kang , Byoung-Taek Choi , Gang-Sun Choi , Yong-Rack Choi , Sung-Ho Hwang
CPC分类号: C07K9/008
摘要: Disclosed is a method for purifying teicoplanin A2 comprising: (i) a primary pre-purification step of purifying a filtrate of fermentation broth of a strain using a synthetic adsorbent; (ii) a secondary pre-purification step of purifying the primary pre-purification solution using a cation exchange resin having a high cross-linkage, a catalytic resin or a chelate resin; (iii) a final purification step of purifying the secondary pre-purification solution using a reversed phase resin; and (iv) a powder-forming step. According to the present invention, it is possible to obtain teicoplanin A2 with a higher purity through a relatively simple process without using an excessive amount of an organic solvent.
摘要翻译: 公开了一种纯化泰可菌素A 2 O 2的方法,其包括:(i)使用合成吸附剂纯化菌株发酵液的滤液的初级预纯化步骤; (ii)使用具有高交联键的阳离子交换树脂,催化树脂或螯合树脂来纯化所述初级预纯化溶液的二次预纯化步骤; (iii)使用反相树脂纯化二次预纯化溶液的最终纯化步骤; 和(iv)粉末形成步骤。 根据本发明,可以通过相对简单的方法获得具有较高纯度的替考拉宁A 2 N 2,而不使用过量的有机溶剂。
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