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    Bioflavonoids as plasma high density lipoprotein level increasing agent
    7.
    发明授权
    Bioflavonoids as plasma high density lipoprotein level increasing agent 有权
    生物类黄酮作为血浆高密度脂蛋白增高剂

    公开(公告)号：US6133241A

    公开(公告)日：2000-10-17

    申请号：US177448

    申请日：1998-10-22

    Applicant: Song-Hae Bok ,  Tae-Sook Jeong ,  Surk-Sik Moon ,  Yong-Kook Kwon ,  Byung-Hwa Hyun ,  Chul-Ho Lee ,  Yang-Kyu Choi ,  Myung-Sook Choi ,  Sung-Gyu Kim ,  Og-Sung Moon ,  Sae-Bom Lee ,  Eun-Sook Lee ,  Byung-Tae Ahn

    Inventor： Song-Hae Bok ,  Tae-Sook Jeong ,  Surk-Sik Moon ,  Yong-Kook Kwon ,  Byung-Hwa Hyun ,  Chul-Ho Lee ,  Yang-Kyu Choi ,  Myung-Sook Choi ,  Sung-Gyu Kim ,  Og-Sung Moon ,  Sae-Bom Lee ,  Eun-Sook Lee ,  Byung-Tae Ahn

    IPC: A23L1/30 ,  A23L2/00 ,  A61K31/352 ,  A61K31/70

    CPC classification number: A61K31/7048 ,  A23L2/00 ,  A23L33/105 ,  A61K31/352 ,  A23V2002/00

    Abstract: A method for increasing the plasma high density lipoprotein(HDL) level in a mammal comprises administering a bioflavonoid of formula(I) or plant extract containing same thereto: ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5.sub.7 R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each independently hydrogen; a hydroxy group; a C.sub.1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.2-10 or C.sub.16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; a rutinosyl group; or a rhaminosyl group; andX is a single or double bond.

    Abstract translation: 一种用于增加哺乳动物血浆高密度脂蛋白（HDL）水平的方法包括施用式（I）的生物类黄酮或含有其的植物提取物：其中，R1，R2，R3，R4，R57，R6，R7，R8和R9 各自独立地为氢; 羟基; 任选地被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自羟基，烷氧基，芳氧基的取代基取代的苯基所取代的C1-9烷氧基 ，卤素，硝基和酰氨基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C5-9环烷氧基; 被选自羟基，烷氧基，芳氧基，卤素，硝基和酰胺基的1〜3个取代基取代的C5-9环烷基羰基氧基; 任选被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个取代基取代的取代基取代的C 2-10或C16-18酰氧基，所述取代基选自羟基 ，烷氧基，芳氧基，卤素和硝基; 芸香酰基; 或者一个去甲基团; X是单键或双键。

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