公开(公告)号：US5897837A

公开(公告)日：1999-04-27

申请号：US796546

申请日：1997-02-06

Applicant: Yoshiteru Mizuno

Inventor： Yoshiteru Mizuno

IPC: G01N35/04 ,  G01N35/10 ,  B01L3/02

CPC classification number: G01N35/109 ,  G01N2035/1076 ,  G01N35/028 ,  G01N35/1004 ,  Y10T436/2575

Abstract: A dispensing device, which may be used with an immunoassay apparatus, includes at least two dispensing pipettes for sucking and discharging liquid; a pipette elevating device for selectively raising and lowering each pipette along an elevating path thereof; a base for holding the pipette elevating device; a base moving device for moving the base; a washing vessel in which each pipette is alternately immersed to be cleaned; and a washing vessel moving device for allowing the washing vessel to selectively move between locations in the elevating paths of the pipettes.

Abstract translation: 可与免疫测定装置一起使用的分配装置包括用于吸取和排出液体的至少两个分配移液管; 一个移液管升降装置，用于沿其升降路径选择性地升高和降低每个移液管; 用于固定移液管升降装置的基座; 用于移动基座的基座移动装置; 洗涤容器，其中每个移液管交替浸入待清洁; 以及洗涤容器移动装置，用于允许洗涤容器选择性地在移液管的升降路径中的位置之间移动。

公开(公告)号：US5215714A

公开(公告)日：1993-06-01

申请号：US709062

申请日：1991-05-30

Applicant: Satoru Okada ,  Yoshiteru Mizuno ,  Takayoshi Izumi ,  Toshihiro Otani

Inventor： Satoru Okada ,  Yoshiteru Mizuno ,  Takayoshi Izumi ,  Toshihiro Otani

IPC: G01N35/10

CPC classification number: G01N35/1009 ,  G01N2035/1025 ,  G01N2035/1086 ,  G01N35/1004

Abstract: A buffer solution is sampled from a buffer solution vessel and is dispensed into a reaction vessel on a reaction table by first sampling/dispensing means, and a specimen containing an antigen or antibody to be measured is sampled from a specimen vessel and is dispensed into the reaction vessel by second sampling/dispensing means. A reagent containing insoluble carriers to which is bonded an antibody or antigen that specifically reacts with the antigen or antibody in the specimen is sampled from a reagent vessel and dispensed into the reaction vessel by third sampling/dispensing means. The entire reaction table is shaken continuously during mixing of the buffer solution, reagent and specimen, and the reaction vessel is maintained in an isothermal state. A stable antigen-antibody reaction in the resulting reaction solution is thus promoted to form an agglutinate of the insoluble carriers. The reaction solution is sampled from the reaction vessel and dispensed into a sample chamber by fourth sampling/dispensing means. The dispensed reaction solution is transferred to a detector through which the insoluble carriers are passed and in which a signal is generated based upon a difference in terms of electrical or optical characteristics. The degree of agglutination of the insoluble carriers is obtained as a numerical value, thus making it possible to quantify the antigen or antibody of interest contained in the specimen.

Abstract translation: 缓冲溶液从缓冲溶液容器中取样，并通过第一取样/分配装置分配到反应台上的反应容器中，并从样品容器中取出含有待测量的抗原或抗体的样品，并将其分配到 反应容器通过第二采样/分配装置。 从试剂容器中取出含有与试样中的抗原或抗体特异性反应的抗体或抗原结合的不溶性载体的试剂，并通过第三取样/分注装置分配到反应容器中。 在缓冲溶液，试剂和试样的混合过程中，整个反应台连续摇动，反应容器保持在等温状态。 因此促进所得反应溶液中的稳定的抗原 - 抗体反应形成不溶性载体的凝集物。 反应溶液从反应容器中取样并通过第四取样/分配装置分配到样品室中。 分配的反应溶液转移到不可溶载体通过的检测器，并且基于电或光学特性的差异产生信号。 获得不溶性载体的凝集度作为数值，从而可以定量试样中包含的感兴趣的抗原或抗体。

公开(公告)号：US5593893A

公开(公告)日：1997-01-14

申请号：US404604

申请日：1995-03-15

Applicant: Masayuki Kobashi ,  Noriaki Koeda ,  Yoshiteru Mizuno ,  Satoru Okada

Inventor： Masayuki Kobashi ,  Noriaki Koeda ,  Yoshiteru Mizuno ,  Satoru Okada

IPC: G01N35/10

CPC classification number: G01N35/1009 ,  G01N2035/1006 ,  G01N2035/1025 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/2575

Abstract: A dispensing device having a flexible tube provided with a pipetting nozzle at an end, a washing solution supplier supplying washing solution to the flexible tube and the pipetting nozzle, a syringe connected to another end of the flexible tube and a control section for controlling the driving of the syringe. The control section of the present invention includes a syringe driving compensator by which the washing solution is supplied into or discharged out of the syringe in an amount compensate for the variation in the inner volume of the tube caused by reduction in the liquid pressure when the washing solution is transmitted from the washing solution supplier into the flexible tube. The liquid surface of the washing solution contained in the pipetting nozzle is maintained at a constant level by actuating the driving compensator in response to the completion of washing of the pipetting nozzle with the washing solution.

Abstract translation: 一种分配装置，其具有在端部设置有移液喷嘴的柔性管，向柔性管提供洗涤溶液的洗涤溶液供应器和移液喷嘴，连接到柔性管的另一端的注射器和用于控制驱动的控制部分 的注射器。 本发明的控制部分包括注射器驱动补偿器，通过该注射器驱动补偿器将洗涤溶液供给到注射器中或从注射器排出，其量补偿当洗涤时液体压力降低引起的管内容积的变化 溶液从洗涤液供应商传输到柔性管中。 包含在移液喷嘴中的洗涤溶液的液体表面响应于用洗涤溶液洗涤移液喷嘴的完成而致动驱动补偿器而保持恒定的水平。