公开(公告)号：US08889881B2

公开(公告)日：2014-11-18

申请号：US13984567

申请日：2012-02-08

申请人： Hae Young Chung ,  Min Hi Park ,  Young Mi Ha ,  Yu Kyeong Han ,  Ji Young Park ,  Yun Jung Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Yu Min Song ,  Hyung Ryong Moon

发明人： Hae Young Chung ,  Min Hi Park ,  Young Mi Ha ,  Yu Kyeong Han ,  Ji Young Park ,  Yun Jung Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Yu Min Song ,  Hyung Ryong Moon

IPC分类号： C07D277/66 ,  A61Q19/02 ,  A61K31/426 ,  C07D235/18 ,  C07D277/06 ,  A61K8/49 ,  A61Q19/06

CPC分类号： A61K8/49 ,  A61K8/4946 ,  A61K8/4986 ,  A61K31/426 ,  A61K2800/78 ,  A61Q19/02 ,  A61Q19/06 ,  C07D235/18 ,  C07D277/06 ,  C07D277/66

摘要： Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

摘要翻译： 提供具有皮肤美白，抗氧化和PPAR活性的新型化合物及其医疗用途，并且该化合物具有抑制酪氨酸酶的皮肤美白活性，因此可用于皮肤美白药物组合物或 化妆品; 具有抗氧化活性，因此可用于预防和治疗皮肤老化; 并具有PPAR活性，特别是PPARα和PPARγ活性，因此可用于有效预防和治疗肥胖，代谢疾病或心血管疾病的药物组合物或保健食品。

公开(公告)号：US20140037564A1

公开(公告)日：2014-02-06

申请号：US13984567

申请日：2012-02-08

申请人： Hae Young Chung ,  Min Hi Park ,  Young Mi Ha ,  Yu Kyeong Han ,  Ji Young Park ,  Yun Jung Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Yu Min Song ,  Hyung Ryong Moon

发明人： Hae Young Chung ,  Min Hi Park ,  Young Mi Ha ,  Yu Kyeong Han ,  Ji Young Park ,  Yun Jung Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Yu Min Song ,  Hyung Ryong Moon

IPC分类号： A61K8/49 ,  A61Q19/02 ,  C07D277/66

CPC分类号： A61K8/49 ,  A61K8/4946 ,  A61K8/4986 ,  A61K31/426 ,  A61K2800/78 ,  A61Q19/02 ,  A61Q19/06 ,  C07D235/18 ,  C07D277/06 ,  C07D277/66

摘要： Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

摘要翻译： 提供具有皮肤美白，抗氧化和PPAR活性的新型化合物及其医疗用途，并且该化合物具有抑制酪氨酸酶的皮肤美白活性，因此可用于皮肤美白药物组合物或 化妆品; 具有抗氧化活性，因此可用于预防和治疗皮肤老化; 并具有PPAR活性，特别是PPARα和PPARγ活性，因此可用于有效预防和治疗肥胖，代谢疾病或心血管疾病的药物组合物或保健食品。

公开(公告)号：US09216148B2

公开(公告)日：2015-12-22

申请号：US13984573

申请日：2012-02-08

申请人： Hae Young Chung ,  Hyung Ryong Moon ,  Min Hi Park ,  Young Mi Ha ,  Yun Jung Park ,  Ji Young Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Kyung Jin Lee

发明人： Hae Young Chung ,  Hyung Ryong Moon ,  Min Hi Park ,  Young Mi Ha ,  Yun Jung Park ,  Ji Young Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Kyung Jin Lee

IPC分类号： A61K8/49 ,  A61Q19/02 ,  A61Q19/08 ,  C07D277/34

CPC分类号： C07D263/42 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/4946 ,  A61K8/4953 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  C07D207/18 ,  C07D207/448 ,  C07D233/96 ,  C07D239/62 ,  C07D277/34

摘要： Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

摘要翻译： 提供具有皮肤美白，抗氧化和PPAR活性的新型化合物及其医疗用途，并且该化合物具有抑制酪氨酸酶的皮肤美白活性，因此可用于皮肤美白药物组合物或 化妆品; 具有抗氧化活性，因此可用于预防和治疗皮肤老化; 并具有PPAR活性，特别是PPARα和PPARγ活性，因此可用于有效预防和治疗肥胖，代谢疾病或心血管疾病的药物组合物或保健食品。

公开(公告)号：US20140023603A1

公开(公告)日：2014-01-23

申请号：US13984573

申请日：2012-02-08

申请人： Hae Young Chung ,  Hyung Ryong Moon ,  Min Hi Park ,  Young Mi Ha ,  Yun Jung Park ,  Ji Young Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Kyung Jin Lee

发明人： Hae Young Chung ,  Hyung Ryong Moon ,  Min Hi Park ,  Young Mi Ha ,  Yun Jung Park ,  Ji Young Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Kyung Jin Lee

IPC分类号： A61K8/49 ,  A61Q19/02

CPC分类号： C07D263/42 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/4946 ,  A61K8/4953 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  C07D207/18 ,  C07D207/448 ,  C07D233/96 ,  C07D239/62 ,  C07D277/34

摘要： Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.