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公开(公告)号:US08133683B2
公开(公告)日:2012-03-13
申请号:US12358884
申请日:2009-01-23
申请人: Yu-Wei Wu , Yu-Hui Tsai
发明人: Yu-Wei Wu , Yu-Hui Tsai
IPC分类号: G01N33/53
CPC分类号: G01N33/54326 , G01N33/58 , G01N33/6803
摘要: The invention develops a high-throughput screening method based on charcoal-sorbent peptide binding assay (CPBA) which does not need a solid phase and can simultaneously detect plural target biomolecules in a sample. The method of the invention can achieve high-throughput screening of biomolecules (such as antibodies and antigens) with a molecular weight of more than 10 KD.
摘要翻译: 本发明开发了基于不需要固相并可以同时检测样品中多个目标生物分子的木炭 - 吸附肽结合测定(CPBA)的高通量筛选方法。 本发明的方法可以实现分子量大于10KD的生物分子(如抗体和抗原)的高通量筛选。
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公开(公告)号:US20100022753A1
公开(公告)日:2010-01-28
申请号:US12179584
申请日:2008-07-25
申请人: Yu-Wei Wu , Yu-Hui Tsai
发明人: Yu-Wei Wu , Yu-Hui Tsai
CPC分类号: C07H21/00 , C07K1/1077 , C07K1/13
摘要: A method for modifying a thiol group is provided. The method includes: providing a first material containing at least one sulfhydryl group; providing a second material containing at least one thiourea group; and reacting the first material with the second material in the presence of copper (II) ions to quickly form a disulfide bond between the sulfhydryl group and the thiourea group, wherein the disulfide bond can be easily reduced.
摘要翻译: 提供了修饰硫醇基团的方法。 该方法包括:提供含有至少一个巯基的第一材料; 提供含有至少一个硫脲基团的第二种材料; 并且在铜(II)离子存在下使第一材料与第二材料反应,以在巯基和硫脲基团之间快速形成二硫键,其中二硫键可以容易地还原。
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公开(公告)号:US20100190189A1
公开(公告)日:2010-07-29
申请号:US12358884
申请日:2009-01-23
申请人: Yu-Wei Wu , Yu-Hui Tsai
发明人: Yu-Wei Wu , Yu-Hui Tsai
IPC分类号: G01N33/53
CPC分类号: G01N33/54326 , G01N33/58 , G01N33/6803
摘要: The invention develops a high-throughput screening method based on charcoal-sorbent peptide binding assay (CPBA) which does not need a solid phase and can simultaneously detect plural target biomolecules in a sample. The method of the invention can achieve high-throughput screening of biomolecules (such as antibodies and antigens) with a molecular weight of more than 10 KD.
摘要翻译: 本发明开发了基于不需要固相并可以同时检测样品中多个目标生物分子的木炭 - 吸附肽结合测定(CPBA)的高通量筛选方法。 本发明的方法可以实现分子量大于10KD的生物分子(如抗体和抗原)的高通量筛选。
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公开(公告)号:US20130030045A1
公开(公告)日:2013-01-31
申请号:US13567934
申请日:2012-08-06
申请人: Yu-Hui TSAI , Yu-Wei Wu , Yu-Hsiang Lin , Wen-Fu Lai , Shih-Ching Chen
发明人: Yu-Hui TSAI , Yu-Wei Wu , Yu-Hsiang Lin , Wen-Fu Lai , Shih-Ching Chen
IPC分类号: A61K31/353 , A61P19/10
CPC分类号: A61K31/353
摘要: The invention discloses a method of preventing and treating osteoporosis. The method comprises a step of enhancing osteoblast differentiation and inhibiting osteoclast differentiation by administering a pharmaceutically effective amount of a composition comprising 6-hydroxy flavone compound or 7-methoxy flavone compound, or at least one pharmaceutically acceptable salt thereof to a subject.
摘要翻译: 本发明公开了一种预防和治疗骨质疏松症的方法。 该方法包括通过向受试者施用药学有效量的包含6-羟基黄酮化合物或7-甲氧基黄酮化合物或其至少一种药学上可接受的盐的组合物来增强成骨细胞分化和抑制破骨细胞分化的步骤。
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