公开(公告)号：US08013175B2

公开(公告)日：2011-09-06

申请号：US12084651

申请日：2006-11-01

申请人： Yukihiro Aoshima ,  Masaaki Nakai

发明人： Yukihiro Aoshima ,  Masaaki Nakai

IPC分类号： C07D307/00 ,  C07D317/00 ,  C07D307/77

CPC分类号： C07D493/04 ,  A61K36/185

摘要： There is disclosed an episesamin refining method in which a mixture of sesamin components that contains sesamin, episesamin and the like is brought into contact with an aqueous medium to form a slurried mixture, and thereafter the solids are separated from the mixture or the slurried mixture is dissolved in a suitable aqueous medium under heating and, thereafter, the solution is slowly cooled to recrystallize, thereby yielding an episesamin-enriched composition with an increased relative episesamin content. By the present invention, episesamin can be conveniently and efficiently refined from a mixture of sesamin components that mainly comprises sesamin and episesamin.

摘要翻译： 公开了一种表芝麻素精制方法，其中将含有芝麻素，表芝麻素等的芝麻素成分的混合物与水性介质接触以形成浆状混合物，然后将固体与混合物分离，或将浆状混合物 在加热下溶解在合适的水性介质中，然后将溶液缓慢冷却至重结晶，从而产生具有增加的相对表芝麻素含量的富含异芝麻素的组合物。 通过本发明，可以从主要包含芝麻素和表芝麻素的芝麻素成分的混合物中方便地有效地提炼表芝麻素。

公开(公告)号：US20090156838A1

公开(公告)日：2009-06-18

申请号：US12084651

申请日：2006-11-01

申请人： Yukihiro Aoshima ,  Masaaki Nakai

发明人： Yukihiro Aoshima ,  Masaaki Nakai

IPC分类号： C07D319/08

CPC分类号： C07D493/04 ,  A61K36/185

摘要： There is disclosed an episesamin refining method in which a mixture of sesamin components that contains sesamin, episesamin and the like is brought into contact with an aqueous medium to form a slurried mixture, and thereafter the solids are separated from the mixture or the slurried mixture is dissolved in a suitable aqueous medium under heating and, thereafter, the solution is slowly cooled to recrystallize, thereby yielding an episesamin-enriched composition with an increased relative episesamin content. By the present invention, episesamin can be conveniently and efficiently refined from a mixture of sesamin components that mainly comprises sesamin and episesamin.

摘要翻译： 公开了一种表芝麻素精制方法，其中将含有芝麻素，表芝麻素等的芝麻素成分的混合物与水性介质接触以形成浆状混合物，然后将固体与混合物分离，或将浆状混合物 在加热下溶解在合适的水性介质中，然后将溶液缓慢冷却至重结晶，从而产生具有增加的相对表芝麻素含量的富含异芝麻素的组合物。 通过本发明，可以从主要包含芝麻素和表芝麻素的芝麻素成分的混合物中方便地有效地提炼表芝麻素。

公开(公告)号：US07943663B2

公开(公告)日：2011-05-17

申请号：US11992196

申请日：2006-09-29

申请人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

发明人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

IPC分类号： A61K31/36

CPC分类号： B01D11/0407 ,  B01D9/0013 ,  B01D9/0022 ,  C07B53/00 ,  C07B61/00 ,  C07B63/00 ,  C07D493/04

摘要： To provide a process and an apparatus by means of which a composition that contains episesamin in a concentration greater than 50 wt % on the basis of the sum weight of sesamin and episesamin can be produced conveniently and at high yield.There are provided a process and an apparatus which comprise the step of applying epimerization to sesamin or a sesamin-containing composition so that at least part of the sesamin is converted to episesamin and the step of selectively crystallizing episesamin by recrystallization and by means of which a composition that contains episesamin in a concentration greater than 50 wt % can be produced conveniently and at high yield.

摘要翻译： 为了提供方法和装置，通过该方法和装置，可以方便地且高产率地制备基于芝麻素和表芝麻素的总重量含有浓度大于50重量％的表芝麻素的组合物。 提供了一种方法和装置，其包括将差向异构化施加于芝麻素或含芝麻素的组合物，使得至少部分芝麻素转化为异芝麻素，以及通过重结晶选择性结晶异芝素的步骤， 含有浓度大于50wt％的表芝麻素的组合物可以方便地且高产率地制备。

公开(公告)号：US20090118363A1

公开(公告)日：2009-05-07

申请号：US12295833

申请日：2007-04-03

申请人： Yukihiro Aoshima ,  Junko Tsuji

发明人： Yukihiro Aoshima ,  Junko Tsuji

IPC分类号： A61K8/49 ,  A61Q5/00 ,  A61Q15/00

CPC分类号： C07D493/04 ,  A23K20/111 ,  A23K20/158 ,  A23K50/40

摘要： Methods for treating coats and/or body odors of animals are provided. Foods and beverages for nonhuman animals that can be used in the methods are provided.Foods and beverages containing a sesamin-class compound(s) of 1 wt % or above and an additive acceptable as a food or beverage are provided. Methods for treating coats and/or body odors of nonhuman animals comprising administering to the nonhuman animals foods or beverages for nonhuman animals containing an effective amount of the sesamin-class compound(s) needed to treat the coats and/or the body odors of the nonhuman animals are provided. Preferably, the sesamin-class compound(s) are dissolved in fat or oil.

摘要翻译： 提供了用于处理动物的外套和/或身体气味的方法。 提供了可用于方法的非人类动物的食物和饮料。 提供含有1重量％以上的芝麻素类化合物和作为食品或饮料可接受的添加剂的食品和饮料。 用于处理非人动物的外套和/或身体气味的方法包括向非人类动物施用含有有效量的芝麻素类化合物的非人动物的食物或饮料，以治疗所述外衣和/或身体气味所需的芝麻素类化合物 提供非人类动物。 优选地，将芝麻素类化合物溶解在脂肪或油中。

公开(公告)号：US20090092733A1

公开(公告)日：2009-04-09

申请号：US12282702

申请日：2007-03-14

申请人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

发明人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

IPC分类号： A23L3/3544 ,  A23L2/38 ,  A23J1/02

CPC分类号： A61K9/0095 ,  A23L33/105 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/1652 ,  A61K9/2059 ,  A61K31/205 ,  A61K31/36 ,  A23V2250/0612 ,  A23V2250/21

摘要： The object of the present invention is to provide a composition for food and beverage comprising a hygroscopic powdery material having improved hygroscopicity as well as food and beverage containing the composition.The present invention provides compositions for food and beverage comprising a hygroscopic powdery material and a sesamin-class compound(s), more specifically powdery compositions for food and beverage comprising a hygroscopic powdery material and a sesamin-class compound(s) mixed with each other wherein the hygroscopic powdery material has improved hygroscopicity as well as foods and beverages containing the compositions.

摘要翻译： 本发明的目的是提供一种用于食品和饮料的组合物，其包含具有改善的吸湿性的吸湿粉末材料以及含有该组合物的食品和饮料。 本发明提供了包含吸湿性粉末材料和芝麻素类化合物的食品和饮料组合物，更具体地，包括吸湿粉末材料和芝麻素类化合物彼此混合的食品和饮料的粉末组合物 其中吸湿性粉末材料具有改善的吸湿性以及含有该组合物的食品和饮料。

公开(公告)号：US20090163583A1

公开(公告)日：2009-06-25

申请号：US11992196

申请日：2006-09-29

申请人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

发明人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

IPC分类号： A61K31/341 ,  B01J19/00

CPC分类号： B01D11/0407 ,  B01D9/0013 ,  B01D9/0022 ,  C07B53/00 ,  C07B61/00 ,  C07B63/00 ,  C07D493/04

摘要： To provide a process and an apparatus by means of which a composition that contains episesamin in a concentration greater than 50 wt % on the basis of the sum weight of sesamin and episesamin can be produced conveniently and at high yield.There are provided a process and an apparatus which comprise the step of applying epimerization to sesamin or a sesamin-containing composition so that at least part of the sesamin is converted to episesamin and the step of selectively crystallizing episesamin by recrystallization and by means of which a composition that contains episesamin in a concentration greater than 50 wt % can be produced conveniently and at high yield.

摘要翻译： 为了提供方法和装置，通过该方法和装置，可以方便地且高产率地制备基于芝麻素和表芝麻素的总重量含有浓度大于50重量％的表芝麻素的组合物。 提供了一种方法和装置，其包括将差向异构化施加于芝麻素或含芝麻素的组合物，使得至少部分芝麻素转化为异芝麻素，以及通过重结晶选择性结晶异芝素的步骤， 含有浓度大于50wt％的表芝麻素的组合物可以方便地且高产率地制备。

公开(公告)号：US09408803B2

公开(公告)日：2016-08-09

申请号：US12295078

申请日：2007-03-14

申请人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

发明人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

IPC分类号： A61K31/36 ,  A61K9/08 ,  A61K9/48 ,  A61K47/14

CPC分类号： A61K9/08 ,  A61K9/4858 ,  A61K31/36 ,  A61K47/14

摘要： An object of the invention is to provide compositions containing lignan-class compounds as dissolved at high concentrations. The compositions having lignan-class compounds such as sesamin and episesamin dissolved in solvent oils or fats that contain triglycerides of middle-chain fatty acids having 8-12 carbon atoms, preferably triglycerides of caprylic acid and/or capric acid and/or lauric acid can contain the lignan-class compounds stably at higher concentrations than when other solvents are used and, hence, have high enough value as foods and pharmaceuticals.

摘要翻译： 本发明的目的是提供含有以高浓度溶解的木脂素类化合物的组合物。 溶解在含有8-12个碳原子的中链脂肪酸甘油三酸酯，优选辛酸和/或癸酸和/或月桂酸的甘油三酸酯的溶剂油或脂肪中的木素素类化合物如芝麻素和表芝麻素的组合物可以溶解在溶剂油或脂肪中， 以比其他溶剂使用的浓度更稳定地含有木脂素类化合物，因此具有足够高的价值作为食品和药物。

公开(公告)号：US20090247625A1

公开(公告)日：2009-10-01

申请号：US12295078

申请日：2007-03-14

申请人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

发明人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

IPC分类号： A61K31/36

CPC分类号： A61K9/08 ,  A61K9/4858 ,  A61K31/36 ,  A61K47/14

摘要： An object of the invention is to provide compositions containing lignan-class compounds as dissolved at high concentrations. The compositions having lignan-class compounds such as sesamin and episesamin dissolved in solvent oils or fats that contain triglycerides of middle-chain fatty acids having 8-12 carbon atoms, preferably triglycerides of caprylic acid and/or capric acid and/or lauric acid can contain the lignan-class compounds stably at higher concentrations than when other solvents are used and, hence, have high enough value as foods and pharmaceuticals.

摘要翻译： 本发明的目的是提供含有以高浓度溶解的木脂素类化合物的组合物。 溶解在含有8-12个碳原子的中链脂肪酸甘油三酸酯，优选辛酸和/或癸酸和/或月桂酸的甘油三酸酯的溶剂油或脂肪中的木素素类化合物如芝麻素和表芝麻素的组合物可以溶解在溶剂油或脂肪中， 以比其他溶剂使用的浓度更稳定地含有木脂素类化合物，因此具有足够高的食品和药物价值。