公开(公告)号：US20090163583A1

公开(公告)日：2009-06-25

申请号：US11992196

申请日：2006-09-29

申请人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

发明人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

IPC分类号： A61K31/341 ,  B01J19/00

CPC分类号： B01D11/0407 ,  B01D9/0013 ,  B01D9/0022 ,  C07B53/00 ,  C07B61/00 ,  C07B63/00 ,  C07D493/04

摘要： To provide a process and an apparatus by means of which a composition that contains episesamin in a concentration greater than 50 wt % on the basis of the sum weight of sesamin and episesamin can be produced conveniently and at high yield.There are provided a process and an apparatus which comprise the step of applying epimerization to sesamin or a sesamin-containing composition so that at least part of the sesamin is converted to episesamin and the step of selectively crystallizing episesamin by recrystallization and by means of which a composition that contains episesamin in a concentration greater than 50 wt % can be produced conveniently and at high yield.

摘要翻译： 为了提供方法和装置，通过该方法和装置，可以方便地且高产率地制备基于芝麻素和表芝麻素的总重量含有浓度大于50重量％的表芝麻素的组合物。 提供了一种方法和装置，其包括将差向异构化施加于芝麻素或含芝麻素的组合物，使得至少部分芝麻素转化为异芝麻素，以及通过重结晶选择性结晶异芝素的步骤， 含有浓度大于50wt％的表芝麻素的组合物可以方便地且高产率地制备。

公开(公告)号：US07943663B2

公开(公告)日：2011-05-17

申请号：US11992196

申请日：2006-09-29

申请人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

发明人： Yukihiro Aoshima ,  Masaaki Nakai ,  Kenji Katano ,  Asako Okada

IPC分类号： A61K31/36

CPC分类号： B01D11/0407 ,  B01D9/0013 ,  B01D9/0022 ,  C07B53/00 ,  C07B61/00 ,  C07B63/00 ,  C07D493/04

摘要： To provide a process and an apparatus by means of which a composition that contains episesamin in a concentration greater than 50 wt % on the basis of the sum weight of sesamin and episesamin can be produced conveniently and at high yield.There are provided a process and an apparatus which comprise the step of applying epimerization to sesamin or a sesamin-containing composition so that at least part of the sesamin is converted to episesamin and the step of selectively crystallizing episesamin by recrystallization and by means of which a composition that contains episesamin in a concentration greater than 50 wt % can be produced conveniently and at high yield.

摘要翻译： 为了提供方法和装置，通过该方法和装置，可以方便地且高产率地制备基于芝麻素和表芝麻素的总重量含有浓度大于50重量％的表芝麻素的组合物。 提供了一种方法和装置，其包括将差向异构化施加于芝麻素或含芝麻素的组合物，使得至少部分芝麻素转化为异芝麻素，以及通过重结晶选择性结晶异芝素的步骤， 含有浓度大于50wt％的表芝麻素的组合物可以方便地且高产率地制备。

公开(公告)号：US20090092733A1

公开(公告)日：2009-04-09

申请号：US12282702

申请日：2007-03-14

申请人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

发明人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

IPC分类号： A23L3/3544 ,  A23L2/38 ,  A23J1/02

CPC分类号： A61K9/0095 ,  A23L33/105 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/1652 ,  A61K9/2059 ,  A61K31/205 ,  A61K31/36 ,  A23V2250/0612 ,  A23V2250/21

摘要： The object of the present invention is to provide a composition for food and beverage comprising a hygroscopic powdery material having improved hygroscopicity as well as food and beverage containing the composition.The present invention provides compositions for food and beverage comprising a hygroscopic powdery material and a sesamin-class compound(s), more specifically powdery compositions for food and beverage comprising a hygroscopic powdery material and a sesamin-class compound(s) mixed with each other wherein the hygroscopic powdery material has improved hygroscopicity as well as foods and beverages containing the compositions.

摘要翻译： 本发明的目的是提供一种用于食品和饮料的组合物，其包含具有改善的吸湿性的吸湿粉末材料以及含有该组合物的食品和饮料。 本发明提供了包含吸湿性粉末材料和芝麻素类化合物的食品和饮料组合物，更具体地，包括吸湿粉末材料和芝麻素类化合物彼此混合的食品和饮料的粉末组合物 其中吸湿性粉末材料具有改善的吸湿性以及含有该组合物的食品和饮料。

公开(公告)号：US09408803B2

公开(公告)日：2016-08-09

申请号：US12295078

申请日：2007-03-14

申请人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

发明人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

IPC分类号： A61K31/36 ,  A61K9/08 ,  A61K9/48 ,  A61K47/14

CPC分类号： A61K9/08 ,  A61K9/4858 ,  A61K31/36 ,  A61K47/14

摘要： An object of the invention is to provide compositions containing lignan-class compounds as dissolved at high concentrations. The compositions having lignan-class compounds such as sesamin and episesamin dissolved in solvent oils or fats that contain triglycerides of middle-chain fatty acids having 8-12 carbon atoms, preferably triglycerides of caprylic acid and/or capric acid and/or lauric acid can contain the lignan-class compounds stably at higher concentrations than when other solvents are used and, hence, have high enough value as foods and pharmaceuticals.

摘要翻译： 本发明的目的是提供含有以高浓度溶解的木脂素类化合物的组合物。 溶解在含有8-12个碳原子的中链脂肪酸甘油三酸酯，优选辛酸和/或癸酸和/或月桂酸的甘油三酸酯的溶剂油或脂肪中的木素素类化合物如芝麻素和表芝麻素的组合物可以溶解在溶剂油或脂肪中， 以比其他溶剂使用的浓度更稳定地含有木脂素类化合物，因此具有足够高的价值作为食品和药物。

公开(公告)号：US20090247625A1

公开(公告)日：2009-10-01

申请号：US12295078

申请日：2007-03-14

申请人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

发明人： Masaaki Nakai ,  Yukihiro Aoshima ,  Shuji Endo

IPC分类号： A61K31/36

CPC分类号： A61K9/08 ,  A61K9/4858 ,  A61K31/36 ,  A61K47/14

摘要： An object of the invention is to provide compositions containing lignan-class compounds as dissolved at high concentrations. The compositions having lignan-class compounds such as sesamin and episesamin dissolved in solvent oils or fats that contain triglycerides of middle-chain fatty acids having 8-12 carbon atoms, preferably triglycerides of caprylic acid and/or capric acid and/or lauric acid can contain the lignan-class compounds stably at higher concentrations than when other solvents are used and, hence, have high enough value as foods and pharmaceuticals.

摘要翻译： 本发明的目的是提供含有以高浓度溶解的木脂素类化合物的组合物。 溶解在含有8-12个碳原子的中链脂肪酸甘油三酸酯，优选辛酸和/或癸酸和/或月桂酸的甘油三酸酯的溶剂油或脂肪中的木素素类化合物如芝麻素和表芝麻素的组合物可以溶解在溶剂油或脂肪中， 以比其他溶剂使用的浓度更稳定地含有木脂素类化合物，因此具有足够高的食品和药物价值。

公开(公告)号：US08013175B2

公开(公告)日：2011-09-06

申请号：US12084651

申请日：2006-11-01

申请人： Yukihiro Aoshima ,  Masaaki Nakai

发明人： Yukihiro Aoshima ,  Masaaki Nakai

IPC分类号： C07D307/00 ,  C07D317/00 ,  C07D307/77

CPC分类号： C07D493/04 ,  A61K36/185

摘要： There is disclosed an episesamin refining method in which a mixture of sesamin components that contains sesamin, episesamin and the like is brought into contact with an aqueous medium to form a slurried mixture, and thereafter the solids are separated from the mixture or the slurried mixture is dissolved in a suitable aqueous medium under heating and, thereafter, the solution is slowly cooled to recrystallize, thereby yielding an episesamin-enriched composition with an increased relative episesamin content. By the present invention, episesamin can be conveniently and efficiently refined from a mixture of sesamin components that mainly comprises sesamin and episesamin.

摘要翻译： 公开了一种表芝麻素精制方法，其中将含有芝麻素，表芝麻素等的芝麻素成分的混合物与水性介质接触以形成浆状混合物，然后将固体与混合物分离，或将浆状混合物 在加热下溶解在合适的水性介质中，然后将溶液缓慢冷却至重结晶，从而产生具有增加的相对表芝麻素含量的富含异芝麻素的组合物。 通过本发明，可以从主要包含芝麻素和表芝麻素的芝麻素成分的混合物中方便地有效地提炼表芝麻素。

公开(公告)号：US20090156838A1

公开(公告)日：2009-06-18

申请号：US12084651

申请日：2006-11-01

申请人： Yukihiro Aoshima ,  Masaaki Nakai

发明人： Yukihiro Aoshima ,  Masaaki Nakai

IPC分类号： C07D319/08

CPC分类号： C07D493/04 ,  A61K36/185

摘要： There is disclosed an episesamin refining method in which a mixture of sesamin components that contains sesamin, episesamin and the like is brought into contact with an aqueous medium to form a slurried mixture, and thereafter the solids are separated from the mixture or the slurried mixture is dissolved in a suitable aqueous medium under heating and, thereafter, the solution is slowly cooled to recrystallize, thereby yielding an episesamin-enriched composition with an increased relative episesamin content. By the present invention, episesamin can be conveniently and efficiently refined from a mixture of sesamin components that mainly comprises sesamin and episesamin.

摘要翻译： 公开了一种表芝麻素精制方法，其中将含有芝麻素，表芝麻素等的芝麻素成分的混合物与水性介质接触以形成浆状混合物，然后将固体与混合物分离，或将浆状混合物 在加热下溶解在合适的水性介质中，然后将溶液缓慢冷却至重结晶，从而产生具有增加的相对表芝麻素含量的富含异芝麻素的组合物。 通过本发明，可以从主要包含芝麻素和表芝麻素的芝麻素成分的混合物中方便地有效地提炼表芝麻素。

公开(公告)号：US08309745B2

公开(公告)日：2012-11-13

申请号：US12872872

申请日：2010-08-31

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

IPC分类号： C07D311/62

CPC分类号： C07D311/62 ,  A23L33/105

摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.

摘要翻译： 本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有 掺入其中的这种脂肪酶活性抑制剂。 本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。 本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。 本发明的另一个目的是提供抗氧化剂。 为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。 结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。 本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

公开(公告)号：US20080275258A1

公开(公告)日：2008-11-06

申请号：US11597291

申请日：2005-05-26

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

IPC分类号： C07D311/04

CPC分类号： C07D311/62 ,  A23L33/105

摘要： It is intended to provide a lipase activity inhibitor which shows a high inhibitory activity on pancreatic lipase, regulates the absorption of fat from meals and/or contributes to the regulation or prevention of obesity, a food and a drink containing the same, and a tea-origin lipase inhibitor being highly preferable and not worsening taste. It is also intended to provide a method of producing the lipase inhibitor. It is further intended to provide antioxidative agent. To overcome these problems, an epigallocatechin dimer (oolong homo bis flavans) or trimer is added to foods or drinks. Thus, the absorption of fat from meals can be regulated and an antioxidative effect can be obtained. The above compounds can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.

摘要翻译： 旨在提供对胰脂肪酶具有高抑制活性的脂肪酶活性抑制剂，调节从膳食中吸收脂肪和/或有助于调节或预防肥胖症的食物和饮料，以及茶 - 原料脂肪酶抑制剂是非常优选的，而不是恶化味道。 还旨在提供一种生产脂肪酶抑制剂的方法。 还旨在提供抗氧化剂。 为了克服这些问题，向食物或饮料中加入表没食子儿茶素二聚体（乌龙同双双黄烷）或三聚体。 因此，可以调节从膳食中吸收脂肪，并且可以获得抗氧化作用。 上述化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

公开(公告)号：US07095199B2

公开(公告)日：2006-08-22

申请号：US11225316

申请日：2005-09-12

申请人： Motohisa Hirose ,  Takashi Kondo ,  Masaaki Nakai ,  Taizo Kikuchi

发明人： Motohisa Hirose ,  Takashi Kondo ,  Masaaki Nakai ,  Taizo Kikuchi

IPC分类号： H02P1/04

CPC分类号： B60S1/0896 ,  B60S1/0818 ,  B60S1/0833

摘要： An automatic vehicle wiper system including a wiper, a speed sensor which measures vehicle speed, a rainfall measuring device which measures amount of rainfall during predetermined intervals, a calculating device which calculates a wiping action frequency of the wiper as first data, depending on the amount of rainfall measured by the rainfall measuring device, a memory device which stores the first data calculated by the calculating device as second data when the vehicle speed measured by the speed sensor decreases to equal to or less than a predetermined value, and a wiping action frequency determining device which determines the wiping action frequency of the wiper by comparing the first data and the second data when the vehicle speed measured by the speed sensor becomes equal to or greater than a predetermined value after it has been confirmed that the vehicle has stopped.