USE OF INTERLEUKIN-22 IN TREATING VIRAL HEPATITIS
    2.
    发明申请
    USE OF INTERLEUKIN-22 IN TREATING VIRAL HEPATITIS 有权
    在治疗病毒性肝炎方面应用INTERLEUKIN-22

    公开(公告)号:US20130171100A1

    公开(公告)日:2013-07-04

    申请号:US13819717

    申请日:2011-08-30

    IPC分类号: C07K14/54

    摘要: This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis virus, and can significantly reduce the increase of transaminase ALT/AST induced by hepatitis virus. In addition, the IL-22 dimer of this invention can effectively treat viral hepatitis.

    摘要翻译: 本发明涉及IL-22在病毒性肝炎治疗中的应用。 如本发明实施例所示,IL-22可显着降低肝炎病毒引起的肝损伤,并能显着降低肝炎病毒诱导的转氨酶ALT / AST的增加。 此外,本发明的IL-22二聚体可以有效治疗病毒性肝炎。

    USE OF G-CSF DIMER IN PREPARATION OF MEDICAMENT FOR TREATMENT OF NEURODEGENERATIVE DISEASES
    5.
    发明申请
    USE OF G-CSF DIMER IN PREPARATION OF MEDICAMENT FOR TREATMENT OF NEURODEGENERATIVE DISEASES 有权
    G-CSF二聚体在制备用于治疗神经损伤性疾病的药物中的应用

    公开(公告)号:US20140248234A1

    公开(公告)日:2014-09-04

    申请号:US14233739

    申请日:2012-07-24

    IPC分类号: A61K47/48

    摘要: The invention discloses the use of the G-CSF dimer in the preparation of a medicament for the treatment of neurodegenerative diseases. Use of the G-CSF dimer of the present invention can significantly increase the number of dopaminergic neuron in the substantia nigra in PD model animals and enhance the function of dopaminergic neurons. In addition, the G-CSF dimer can significantly reduce apoptosis of neuron in hippocampus and improve learning and memory ability of AD model rats. Serum half-life of the G-CSF dimer of the invention is prolonged and the loss of neurons is effectively prevented, providing a better therapeutic effect in treatment of neurodegenerative disease.

    摘要翻译: 本发明公开了G-CSF二聚体在制备用于治疗神经变性疾病的药物中的用途。 本发明的G-CSF二聚体的使用可以显着增加PD模型动物中黑质中多巴胺能神经元的数量,并增强多巴胺能神经元的功能。 此外,G-CSF二聚体可显着减少海马神经元凋亡,提高AD模型大鼠的学习记忆能力。 本发明的G-CSF二聚体的血清半衰期延长,有效地防止了神经元的损失,为治疗神经变性疾病提供了更好的治疗效果。