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1.发明授权公开(公告)号：US09642917B2
公开(公告)日：2017-05-09
申请号：US14233739
申请日：2012-07-24
申请人： Dong-Dong Wu , Zhihua Huang , Yuliang Huang , Xiaoqiang Yan
发明人： Dong-Dong Wu , Zhihua Huang , Yuliang Huang , Xiaoqiang Yan
CPC分类号： A61K47/48269 , A61K38/19 , A61K47/642
摘要： The invention discloses the use of the G-CSF dimer in the preparation of a medicament for the treatment of neurodegenerative diseases. Use of the G-CSF dimer of the present invention can significantly increase the number of dopaminergic neuron in the substantia nigra in PD model animals and enhance the function of dopaminergic neurons. In addition, the G-CSF dimer can significantly reduce apoptosis of neuron in hippocampus and improve learning and memory ability of AD model rats. Serum half-life of the G-CSF dimer of the invention is prolonged and the loss of neurons is effectively prevented, providing a better therapeutic effect in treatment of neurodegenerative disease.
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2.发明申请USE OF G-CSF DIMER IN PREPARATION OF MEDICAMENT FOR TREATMENT OF NEURODEGENERATIVE DISEASES 有权G-CSF二聚体在制备用于治疗神经损伤性疾病的药物中的应用公开(公告)号：US20140248234A1
公开(公告)日：2014-09-04
申请号：US14233739
申请日：2012-07-24
申请人： Dong-Dong Wu , Zhihua Huang , Yuliang Huang , Xiaoqiang Yan
发明人： Dong-Dong Wu , Zhihua Huang , Yuliang Huang , Xiaoqiang Yan
IPC分类号： A61K47/48
CPC分类号： A61K47/48269 , A61K38/19 , A61K47/642
摘要： The invention discloses the use of the G-CSF dimer in the preparation of a medicament for the treatment of neurodegenerative diseases. Use of the G-CSF dimer of the present invention can significantly increase the number of dopaminergic neuron in the substantia nigra in PD model animals and enhance the function of dopaminergic neurons. In addition, the G-CSF dimer can significantly reduce apoptosis of neuron in hippocampus and improve learning and memory ability of AD model rats. Serum half-life of the G-CSF dimer of the invention is prolonged and the loss of neurons is effectively prevented, providing a better therapeutic effect in treatment of neurodegenerative disease.
摘要翻译： 本发明公开了G-CSF二聚体在制备用于治疗神经变性疾病的药物中的用途。 本发明的G-CSF二聚体的使用可以显着增加PD模型动物中黑质中多巴胺能神经元的数量，并增强多巴胺能神经元的功能。 此外，G-CSF二聚体可显着减少海马神经元凋亡，提高AD模型大鼠的学习记忆能力。 本发明的G-CSF二聚体的血清半衰期延长，有效地防止了神经元的损失，为治疗神经变性疾病提供了更好的治疗效果。
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3.发明授权Recombinant human G-CSF dimer and use thereof for the treatment of neurological diseases 有权重组人G-CSF二聚体及其用于治疗神经疾病的用途公开(公告)号：US08557546B2
公开(公告)日：2013-10-15
申请号：US13114035
申请日：2011-05-23
申请人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Bill N. C. Sun , Yuliang Huang
发明人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Bill N. C. Sun , Yuliang Huang
IPC分类号： C07K16/00 , C07K14/535 , C12N15/09 , C12N15/24 , A61P25/00
CPC分类号： C07K14/535 , A61K38/193 , C07K2319/00 , C07K2319/30
摘要： This invention relates to a recombinant human G-CSF (rhG-CSF) dimer and its use in the treatment of neurological disorder. In particular, upon ischemic neural injury in animal, this invention can be used to protect neurons with the use of rhG-CSF dimer such that function of injured nerves can be restored. Serum half-life of G-CSF dimer of this invention is prolonged and the biological activity thereof is increased.
摘要翻译： 本发明涉及重组人G-CSF（rhG-CSF）二聚体及其在神经障碍治疗中的应用。 特别地，在动物缺血性神经损伤中，本发明可用于通过使用rhG-CSF二聚体来保护神经元，从而能够恢复受损的神经的功能。 本发明的G-CSF二聚体的血清半衰期延长，其生物活性增加。
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公开(公告)号：US08945528B2
公开(公告)日：2015-02-03
申请号：US13819717
申请日：2011-08-30
申请人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Yuliang Huang
发明人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Yuliang Huang
CPC分类号： A61K38/20 , A61K35/407 , C07K14/54 , Y02A50/463 , Y10S514/883
摘要： This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis virus, and can significantly reduce the increase of transaminase ALT/AST induced by hepatitis virus. In addition, the IL-22 dimer of this invention can effectively treat viral hepatitis.
摘要翻译： 本发明涉及IL-22在病毒性肝炎治疗中的应用。 如本发明实施例所示，IL-22可显着降低肝炎病毒引起的肝损伤，并能显着降低肝炎病毒诱导的转氨酶ALT / AST的增加。 此外，本发明的IL-22二聚体可以有效治疗病毒性肝炎。
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公开(公告)号：US20130171100A1
公开(公告)日：2013-07-04
申请号：US13819717
申请日：2011-08-30
申请人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Yuliang Huang
发明人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Yuliang Huang
IPC分类号： C07K14/54
CPC分类号： A61K38/20 , A61K35/407 , C07K14/54 , Y02A50/463 , Y10S514/883
摘要： This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis virus, and can significantly reduce the increase of transaminase ALT/AST induced by hepatitis virus. In addition, the IL-22 dimer of this invention can effectively treat viral hepatitis.
摘要翻译： 本发明涉及IL-22在病毒性肝炎治疗中的应用。 如本发明实施例所示，IL-22可显着降低肝炎病毒引起的肝损伤，并能显着降低肝炎病毒诱导的转氨酶ALT / AST的增加。 此外，本发明的IL-22二聚体可以有效治疗病毒性肝炎。
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公开(公告)号：US20130165637A1
公开(公告)日：2013-06-27
申请号：US13819716
申请日：2011-08-31
申请人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Bill, N.C. Sun , Yuliang Huang
发明人： Xiaoqiang Yan , Zhihua Huang , Hongzhou Yang , Bill, N.C. Sun , Yuliang Huang
IPC分类号： C07K14/535 , C07K16/46 , C07K14/76
CPC分类号： A61K47/48423 , A61K38/193 , A61K47/6813
摘要： This invention relates to a use of G-CSF dimer in the treatment of neutropenia. In particular, the recombinant human G-CSF of the present invention can enhance the differentiation and development of neutrophils in animal, and thus effectively reduce the severity of the severe neutropenia and shorten the time of severe neutropenia for the post-chemotherapy cancer patients. Serum half-life of G-CSF dimer of this invention is prolonged and the biological activity thereof is increased, providing a better effect in the treatment of neutropenia.
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公开(公告)号：USD912778S1
公开(公告)日：2021-03-09
申请号：US29706257
申请日：2019-09-19
申请人： Zhihua Huang
设计人： Zhihua Huang
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公开(公告)号：USD944932S1
公开(公告)日：2022-03-01
申请号：US29782732
申请日：2021-05-08
申请人： Zhihua Huang
设计人： Zhihua Huang
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公开(公告)号：USD912776S1
公开(公告)日：2021-03-09
申请号：US29705791
申请日：2019-09-16
申请人： Zhihua Huang
设计人： Zhihua Huang
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公开(公告)号：USD940273S1
公开(公告)日：2022-01-04
申请号：US29706258
申请日：2019-09-19
申请人： Zhihua Huang
设计人： Zhihua Huang
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