公开(公告)号：US20220409734A1

公开(公告)日：2022-12-29

申请号：US17610391

申请日：2020-05-08

申请人： Yutaka NISHIMOTO ,  Yumiko ISHII ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Dylan Bradley ENGLAND ,  Steve P. LANGSTON ,  Hong Myung LEE ,  Liting MA ,  Zhan SHI ,  Stepan VYSKOCIL ,  Jianing WANG ,  He XU ,  Yutaka NISHIMOTO ,  Yumiko ISHII

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00

摘要： The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof. Formula (I):

公开(公告)号：US20130243859A1

公开(公告)日：2013-09-19

申请号：US13991052

申请日：2011-12-02

申请人： Yasushi Mima ,  Tetsuya Kawano ,  Yumiko Ishii

发明人： Yasushi Mima ,  Tetsuya Kawano ,  Yumiko Ishii

IPC分类号： A61K9/24 ,  A61K31/4439 ,  A61K31/616

摘要： The present invention relates to a multi-layer orally disintegrating tablet having (1) an enteric fine granule-containing layer containing a proton pump inhibitor and (2) an acetylsalicylic acid-containing layer, which shows high stability of the active ingredients (proton pump inhibitor, aspirin) and expresses the pharmacological effects of the active ingredients stably and rapidly after administration.

摘要翻译： 本发明涉及一种多层口腔崩解片，其具有（1）含有质子泵抑制剂的肠溶微粒含有层和（2）含有活性成分（质子泵）的高稳定性的乙酰水杨酸含有层 抑制剂，阿斯匹林），并在给药后稳定且快速地表达活性成分的药理作用。