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公开(公告)号：US20220409734A1
公开(公告)日：2022-12-29
申请号：US17610391
申请日：2020-05-08
发明人： Dylan Bradley ENGLAND , Steve P. LANGSTON , Hong Myung LEE , Liting MA , Zhan SHI , Stepan VYSKOCIL , Jianing WANG , He XU , Yutaka NISHIMOTO , Yumiko ISHII
摘要： The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof. Formula (I):
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公开(公告)号：US20210015915A1
公开(公告)日：2021-01-21
申请号：US17040083
申请日：2019-03-22
发明人： Jeffrey CIAVARRI , Dylan Bradley ENGLAND , Kenneth M. GIGSTAD , Alexandra E. GOULD , Paul GREENSPAN , Yongbo HU , Shi-Chung HUANG , Steven Paul LANGSTON , Hirotake MIZUTANI , Zhan SHI , Stepan VYSKOCIL , He XU
摘要： The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240209017A1
公开(公告)日：2024-06-27
申请号：US18052083
申请日：2022-11-02
发明人： Stepan VYSKOCIL , Jeffrey CIAVARRI , Courtney CULLIS , Dylan Bradley ENGLAND , Alexandra E. GOULD , Paul GREENSPAN , Yongbo HU , Steven LANGSTON , Gang LI , Hirotake MIZUTANI , Masanori OKANIWA
IPC分类号： C07H19/207
CPC分类号： C07H19/207
摘要： The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.
The present disclosure relates to a compound represented by the Formula (I):
wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US20210171565A1
公开(公告)日：2021-06-10
申请号：US16762710
申请日：2018-11-09
发明人： Stepan VYSKOCIL , Jeffrey CIAVARRI , Courtney CULLIS , Dylan Bradley ENGLAND , Alexandra E. GOULD , Paul GREENSPAN , Yongbo HU , Steven LANGSTON , Gang LI , Hirotake MIZUTANI , Masanori OKANIWA
IPC分类号： C07H19/207
摘要： The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases. The present disclosure relates to a compound represented by the Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
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