公开(公告)号：US20220409734A1

公开(公告)日：2022-12-29

申请号：US17610391

申请日：2020-05-08

申请人： Yutaka NISHIMOTO ,  Yumiko ISHII ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Dylan Bradley ENGLAND ,  Steve P. LANGSTON ,  Hong Myung LEE ,  Liting MA ,  Zhan SHI ,  Stepan VYSKOCIL ,  Jianing WANG ,  He XU ,  Yutaka NISHIMOTO ,  Yumiko ISHII

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00

摘要： The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof. Formula (I):

公开(公告)号：US20180036250A1

公开(公告)日：2018-02-08

申请号：US15553852

申请日：2016-02-25

申请人： Takeda Pharmaceutical Company Limited

发明人： Ikuro YAMANE ,  Yukihiro NOMURA ,  Yutaka NISHIMOTO ,  Wataru HOSHINA

IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K31/519

CPC分类号： A61K9/2031 ,  A61K9/20 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2886 ,  A61K31/519 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

摘要： Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizing the compound in a solid preparation.A tablet containing not less than 25 mass % of the compound; a solid preparation containing (1) the compound, and (2) a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate; a method of stabilizing the compound in a tablet, including adding not less than 25 mass % of the compound; and a method of stabilizing the compound, including adding a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate to a solid preparation containing the compound.

公开(公告)号：US20200000730A1

公开(公告)日：2020-01-02

申请号：US16432091

申请日：2019-06-05

申请人： Takeda Pharmaceutical Company Limited

发明人： Ikuro YAMANE ,  Yukihiro NOMURA ,  Yutaka NISHIMOTO ,  Wataru HOSHINA

IPC分类号： A61K9/20 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K31/519 ,  A61K9/28

摘要： Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizing the compound in a solid preparation.A tablet containing not less than 25 mass % of the compound; a solid preparation containing (1) the compound, and (2) a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate; a method of stabilizing the compound in a tablet, including adding not less than 25 mass % of the compound; and a method of stabilizing the compound, including adding a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate to a solid preparation containing the compound.