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公开(公告)号：US20220409734A1
公开(公告)日：2022-12-29
申请号：US17610391
申请日：2020-05-08
发明人： Dylan Bradley ENGLAND , Steve P. LANGSTON , Hong Myung LEE , Liting MA , Zhan SHI , Stepan VYSKOCIL , Jianing WANG , He XU , Yutaka NISHIMOTO , Yumiko ISHII
摘要： The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof. Formula (I):
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公开(公告)号：US20230293522A1
公开(公告)日：2023-09-21
申请号：US18045748
申请日：2022-10-11
发明人： Matthew O. DUFFEY , Dylan ENGLAND , Brian Scott FREEZE , Zhigen HU , Steven LANGSTON , Charles MCINTYRE , Hirotake MIZUTANI , Koji ONO , He XU
IPC分类号： A61K31/506 , C07D409/14 , C07D409/06 , C07D405/06 , C07D471/04 , C07D495/04 , C07D487/04 , C07D491/052 , C07D513/04 , C07D498/04 , C07D493/04 , A61K31/505 , A61K31/34 , C07F9/535 , C07F9/54 , C07F9/6558 , C07F9/655
CPC分类号： A61K31/506 , C07D409/14 , C07D409/06 , C07D405/06 , C07D471/04 , C07D495/04 , C07D487/04 , C07D491/052 , C07D513/04 , C07D498/04 , C07D493/04 , A61K31/505 , A61K31/34 , C07F9/5352 , C07F9/5442 , C07F9/65586 , C07F9/65522
摘要： Disclosed are chemical entities which are compounds of formula (I):
or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra′, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.-
公开(公告)号：US20220249536A1
公开(公告)日：2022-08-11
申请号：US17730924
申请日：2022-04-27
发明人： He XU , Hong Myung LEE , Christopher ARENDT
IPC分类号： A61K31/7084 , A61K47/68 , A61P35/00
摘要： The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.
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公开(公告)号：US20210015915A1
公开(公告)日：2021-01-21
申请号：US17040083
申请日：2019-03-22
发明人： Jeffrey CIAVARRI , Dylan Bradley ENGLAND , Kenneth M. GIGSTAD , Alexandra E. GOULD , Paul GREENSPAN , Yongbo HU , Shi-Chung HUANG , Steven Paul LANGSTON , Hirotake MIZUTANI , Zhan SHI , Stepan VYSKOCIL , He XU
摘要： The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220168330A1
公开(公告)日：2022-06-02
申请号：US17522623
申请日：2021-11-09
发明人： He XU , Hong Myung LEE , Christopher ARENDT
IPC分类号： A61K31/7084 , A61K47/68 , A61P35/00
摘要： The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.
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公开(公告)号：US20230399356A1
公开(公告)日：2023-12-14
申请号：US18336436
申请日：2023-06-16
发明人： He XU , Hong Myung LEE , Christopher ARENDT
IPC分类号： C07H21/00 , A61K47/68 , A61P35/00 , A61K31/7084
CPC分类号： C07H21/00 , A61K47/6849 , A61P35/00 , A61K31/7084 , A61K47/6889
摘要： The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.
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