公开(公告)号：US20070167486A1

公开(公告)日：2007-07-19

申请号：US10557085

申请日：2004-05-17

申请人： Yung Kho ,  Gyoon Han ,  Ho Lee ,  Bum Park ,  Hyo Chun ,  Hwan Kim ,  Song Park ,  Sang Han ,  Dong Ryu ,  Tae Chun ,  Jin Lee ,  Chang Lee ,  Ki Lee ,  Hee Lee

发明人： Yung Kho ,  Gyoon Han ,  Ho Lee ,  Bum Park ,  Hyo Chun ,  Hwan Kim ,  Song Park ,  Sang Han ,  Dong Ryu ,  Tae Chun ,  Jin Lee ,  Chang Lee ,  Ki Lee ,  Hee Lee

IPC分类号： A61K31/4545 ,  A61K31/445 ,  A61K31/454 ,  C07D401/02

CPC分类号： C07D207/26 ,  C07D207/38 ,  C07D211/86 ,  C07D409/06

摘要： The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

摘要翻译： 本发明涉及新的2-氧代环状化合物及其制备方法和包含其的药物组合物。 本发明提供了用于预防和治疗炎性疾病的药物组合物，其包括由风湿性疾病引起的疼痛或炎症，例如类风湿性关节炎，脊椎动物病变，痛风，骨关节炎，系统性红斑狼疮和幼年关节炎以及炎性综合征，例如， 肌炎，牙龈炎，滑膜炎，强直性脊柱炎，爆发性炎症，烧伤和瘢痕，炎性克罗恩病，I型糖尿病。 因此，它可以用作治疗和预防炎性疾病的治疗剂。

公开(公告)号：US20060173043A1

公开(公告)日：2006-08-03

申请号：US10564653

申请日：2004-07-15

申请人： Gyoon Han ,  Hwan Kim ,  Song Park ,  Chang-Woo Lee ,  Sang Han ,  Ki Lee ,  Yung Kho ,  Jin Yang ,  Bum Park ,  Hyang Lee ,  Jeung Han ,  Dong Ryu ,  Jin Lee ,  Tae Chun ,  Yong Kim ,  Hee Lee ,  Bong Lee ,  Jeom Kim ,  Ji Kim ,  Kyunga Yu ,  Sun Kim

发明人： Gyoon Han ,  Hwan Kim ,  Song Park ,  Chang-Woo Lee ,  Sang Han ,  Ki Lee ,  Yung Kho ,  Jin Yang ,  Bum Park ,  Hyang Lee ,  Jeung Han ,  Dong Ryu ,  Jin Lee ,  Tae Chun ,  Yong Kim ,  Hee Lee ,  Bong Lee ,  Jeom Kim ,  Ji Kim ,  Kyunga Yu ,  Sun Kim

IPC分类号： A61K31/4545 ,  A61K31/454

CPC分类号： A61K31/454 ,  A61K31/4015 ,  A61K31/4545 ,  C07D207/38 ,  C07D211/86 ,  C07D223/10 ,  C07D417/06

摘要： The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.

摘要翻译： 本发明涉及具有抗癌活性的2-氧代杂环化合物及其制备方法的新用途以及包含其的药物组合物。 本发明提供了用于预防和治疗包括肺癌，骨癌，胰腺癌，皮肤癌，头颈癌，皮肤或眼内黑素瘤，子宫癌，卵巢癌，直肠癌或癌症的癌症疾病的药物组合物 肛门区域，胃癌，结肠癌，乳腺癌，妇科肿瘤，霍奇金病，食道癌，小肠癌，内分泌系统癌，软组织肉瘤，尿道癌，阴茎癌 ，前列腺癌，慢性或急性白血病，儿童实体瘤，淋巴细胞淋巴管，膀胱癌，肾或输尿管癌，或中枢神经系统肿瘤，因此可用作治疗和预防的治疗剂 癌症疾病