公开(公告)号：US11708637B2

公开(公告)日：2023-07-25

申请号：US16987173

申请日：2020-08-06

Applicant: Bong-Gyoon Han ,  Robert M. Glaeser

Inventor： Bong-Gyoon Han ,  Robert M. Glaeser

IPC: C23F1/18 ,  H01J37/20 ,  C01B32/194 ,  C23F1/08 ,  A61P35/00 ,  A61K9/19 ,  A61K9/51 ,  C07H19/10

CPC classification number: C23F1/18 ,  A61K9/19 ,  A61K9/5169 ,  A61P35/00 ,  C01B32/194 ,  C07H19/10 ,  C23F1/08 ,  H01J37/20 ,  C01B2204/02 ,  C01B2204/04 ,  H01J2235/183 ,  H01J2237/20 ,  H01J2237/26

Abstract: This disclosure provides systems, methods, and apparatus related to graphene. In one aspect, a method includes submerging a frame support in an etching solution that is contained in a container. A growth substrate, a graphene sheet disposed on the growth substrate, and a primary support disposed on the graphene sheet is placed on a surface of the etching solution. The growth substrate is dissolved in the etching solution to leave the graphene sheet and the primary support floating on a surface of the etching solution. The etching solution in the container is replaced with a washing solution. The washing solution is removed from the container so that the graphene sheet becomes disposed on the frame support.

公开(公告)号：US20230012465A9

公开(公告)日：2023-01-12

申请号：US16987173

申请日：2020-08-06

Applicant: Bong-Gyoon Han ,  Robert M. Glaeser

Inventor： Bong-Gyoon Han ,  Robert M. Glaeser

IPC: C23F1/18 ,  H01J37/20 ,  C01B32/194 ,  C23F1/08

Abstract: This disclosure provides systems, methods, and apparatus related to graphene. In one aspect, a method includes submerging a frame support in an etching solution that is contained in a container. A growth substrate, a graphene sheet disposed on the growth substrate, and a primary support disposed on the graphene sheet is placed on a surface of the etching solution. The growth substrate is dissolved in the etching solution to leave the graphene sheet and the primary support floating on a surface of the etching solution. The etching solution in the container is replaced with a washing solution. The washing solution is removed from the container so that the graphene sheet becomes disposed on the frame support.

公开(公告)号：US20060173043A1

公开(公告)日：2006-08-03

申请号：US10564653

申请日：2004-07-15

Applicant: Gyoon Han ,  Hwan Kim ,  Song Park ,  Chang-Woo Lee ,  Sang Han ,  Ki Lee ,  Yung Kho ,  Jin Yang ,  Bum Park ,  Hyang Lee ,  Jeung Han ,  Dong Ryu ,  Jin Lee ,  Tae Chun ,  Yong Kim ,  Hee Lee ,  Bong Lee ,  Jeom Kim ,  Ji Kim ,  Kyunga Yu ,  Sun Kim

Inventor： Gyoon Han ,  Hwan Kim ,  Song Park ,  Chang-Woo Lee ,  Sang Han ,  Ki Lee ,  Yung Kho ,  Jin Yang ,  Bum Park ,  Hyang Lee ,  Jeung Han ,  Dong Ryu ,  Jin Lee ,  Tae Chun ,  Yong Kim ,  Hee Lee ,  Bong Lee ,  Jeom Kim ,  Ji Kim ,  Kyunga Yu ,  Sun Kim

IPC: A61K31/4545 ,  A61K31/454

CPC classification number: A61K31/454 ,  A61K31/4015 ,  A61K31/4545 ,  C07D207/38 ,  C07D211/86 ,  C07D223/10 ,  C07D417/06

Abstract: The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.

Abstract translation: 本发明涉及具有抗癌活性的2-氧代杂环化合物及其制备方法的新用途以及包含其的药物组合物。 本发明提供了用于预防和治疗包括肺癌，骨癌，胰腺癌，皮肤癌，头颈癌，皮肤或眼内黑素瘤，子宫癌，卵巢癌，直肠癌或癌症的癌症疾病的药物组合物 肛门区域，胃癌，结肠癌，乳腺癌，妇科肿瘤，霍奇金病，食道癌，小肠癌，内分泌系统癌，软组织肉瘤，尿道癌，阴茎癌 ，前列腺癌，慢性或急性白血病，儿童实体瘤，淋巴细胞淋巴管，膀胱癌，肾或输尿管癌，或中枢神经系统肿瘤，因此可用作治疗和预防的治疗剂 癌症疾病

公开(公告)号：US20070167486A1

公开(公告)日：2007-07-19

申请号：US10557085

申请日：2004-05-17

Applicant: Yung Kho ,  Gyoon Han ,  Ho Lee ,  Bum Park ,  Hyo Chun ,  Hwan Kim ,  Song Park ,  Sang Han ,  Dong Ryu ,  Tae Chun ,  Jin Lee ,  Chang Lee ,  Ki Lee ,  Hee Lee

Inventor： Yung Kho ,  Gyoon Han ,  Ho Lee ,  Bum Park ,  Hyo Chun ,  Hwan Kim ,  Song Park ,  Sang Han ,  Dong Ryu ,  Tae Chun ,  Jin Lee ,  Chang Lee ,  Ki Lee ,  Hee Lee

IPC: A61K31/4545 ,  A61K31/445 ,  A61K31/454 ,  C07D401/02

CPC classification number: C07D207/26 ,  C07D207/38 ,  C07D211/86 ,  C07D409/06

Abstract: The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

Abstract translation: 本发明涉及新的2-氧代环状化合物及其制备方法和包含其的药物组合物。 本发明提供了用于预防和治疗炎性疾病的药物组合物，其包括由风湿性疾病引起的疼痛或炎症，例如类风湿性关节炎，脊椎动物病变，痛风，骨关节炎，系统性红斑狼疮和幼年关节炎以及炎性综合征，例如， 肌炎，牙龈炎，滑膜炎，强直性脊柱炎，爆发性炎症，烧伤和瘢痕，炎性克罗恩病，I型糖尿病。 因此，它可以用作治疗和预防炎性疾病的治疗剂。

公开(公告)号：US20210047740A1

公开(公告)日：2021-02-18

申请号：US16987173

申请日：2020-08-06

Applicant: Bong-Gyoon Han ,  Robert M. Glaeser

Inventor： Bong-Gyoon Han ,  Robert M. Glaeser

IPC: C23F1/18 ,  H01J37/20 ,  C01B32/194 ,  C23F1/08

Abstract: This disclosure provides systems, methods, and apparatus related to graphene. In one aspect, a method includes submerging a frame support in an etching solution that is contained in a container. A growth substrate, a graphene sheet disposed on the growth substrate, and a primary support disposed on the graphene sheet is placed on a surface of the etching solution. The growth substrate is dissolved in the etching solution to leave the graphene sheet and the primary support floating on a surface of the etching solution. The etching solution in the container is replaced with a washing solution. The washing solution is removed from the container so that the graphene sheet becomes disposed on the frame support.

公开(公告)号：US20120043208A1

公开(公告)日：2012-02-23

申请号：US13176704

申请日：2011-07-05

Applicant: Jian Jin ,  Mark D. Biggin ,  Robert A. Nordmeyer ,  Ming Dong ,  Earl W. Cornell ,  Megan Choi ,  Halina Ewa Witkowski ,  Bong-Gyoon Han ,  Robert M. Glaeser

Inventor： Jian Jin ,  Mark D. Biggin ,  Robert A. Nordmeyer ,  Ming Dong ,  Earl W. Cornell ,  Megan Choi ,  Halina Ewa Witkowski ,  Bong-Gyoon Han ,  Robert M. Glaeser

IPC: G01N33/559 ,  C25B7/00 ,  G01N27/447

CPC classification number: G01N27/44756 ,  G01N27/44769

Abstract: A multi-channel gel electrophoresis apparatus for efficiently collecting molecules isolated by gel electrophoresis so they can be further analyzed, identified, or used as reagents or medications. The apparatus using a novel “tagless” strategy that combines multi-dimensional separation of endogenous complexes with mass spectrometric monitoring of their composition. In this procedure, putative protein complexes are identified based on the co-migration of collections of polypeptides through multiple orthogonal separation steps. A majority of E. coli proteins are shown to remain in stable complexes during fractionation of a crude extract through three chromatographic steps.

Abstract translation: 一种用于有效收集通过凝胶电泳分离的分子的多通道凝胶电泳装置，因此可以进一步分析，鉴定或用作试剂或药物。 该装置使用将内源性复合物的多维分离与其组成的质谱监测相结合的新型“无标记”策略。 在该方法中，基于通过多个正交分离步骤的多肽集合的共同迁移来鉴定推定的蛋白质复合物。 显示大部分大肠杆菌蛋白质通过三个色谱步骤在粗提取物分馏期间保持在稳定的络合物中。