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    Medicament for the treatment of viral skin and tumour diseases
    1.
    发明申请
    Medicament for the treatment of viral skin and tumour diseases 有权
    用于治疗病毒性皮肤和肿瘤疾病的药物

    公开(公告)号：US20050032895A1

    公开(公告)日：2005-02-10

    申请号：US10495889

    申请日：2002-11-18

    申请人： Yunik Chang ,  Robert Lathrop ,  Erwin Bohm ,  Irene Gander-Meisterernst ,  Ulrich Moebius ,  Johanna Holldack ,  Ulrich Moebius

    发明人： Yunik Chang ,  Robert Lathrop ,  Erwin Bohm ,  Irene Gander-Meisterernst ,  Ulrich Moebius ,  Johanna Holldack ,  Ulrich Moebius

    IPC分类号： A61K31/12 ,  A61K31/20 ,  A61K31/23 ,  A61K31/25 ,  A61K31/353 ,  A61K36/18 ,  A61K45/00 ,  A61K45/06 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61P15/00 ,  A61P17/00 ,  A61P17/12 ,  A61P31/12 ,  A61P31/20 ,  A61P31/22

    CPC分类号： A61K9/0014 ,  A61K31/23 ,  A61K31/353 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  Y10S514/934 ,  Y10S514/947 ,  Y10S514/967 ,  Y10S514/969 ,  A61K2300/00

    摘要： The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m—O]nH group with n=1 to 10, preferably n=1 to 5, m==1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2-(R3)]— group, where R3=independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumour diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.

    摘要翻译： 本发明涉及含有通式（1）化合物的药物，其中R1独立地为直链或支链的饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基，优选C1- C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m O] n H基，优选n = 1〜5，m = 1〜5，优选m = 1〜3，-CH 2 - [CH-（OH）] p [CH 2 - （R 3）] - 基，其中R 3 =独立的H或OH，p = 1至7，优选p = 1至4，戊糖基或己糖基团，作为治疗活性剂，单独或与一种或几种其它药剂组合，作为用于治疗病毒的组合制剂 特别是由人乳头瘤病毒（HPV）和/或疱疹病毒引起的皮肤疾病和/或肿瘤疾病以及局部作用的药物制剂及其用途。

    Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent
    2.
    发明申请
    Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent 有权
    在水中悬浮液中含有低浓度过氧化苯甲酰和水混溶性有机溶剂的局部药物制剂

    公开(公告)号：US20090306172A1

    公开(公告)日：2009-12-10

    申请号：US12455525

    申请日：2009-06-03

    申请人： Yunik Chang ,  Gordon J. Dow

    发明人： Yunik Chang ,  Gordon J. Dow

    IPC分类号： A61K31/4025 ,  A61K31/327 ,  A61P17/10

    CPC分类号： A61K31/7056 ,  A61K8/0241 ,  A61K8/042 ,  A61K8/044 ,  A61K8/345 ,  A61K8/38 ,  A61K8/55 ,  A61K9/0014 ,  A61K9/14 ,  A61K31/075 ,  A61K31/235 ,  A61K31/327 ,  A61K45/06 ,  A61K47/10 ,  A61K47/32 ,  A61K2800/33 ,  A61K2800/413 ,  A61Q19/00 ,  A61K2300/00

    摘要： An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.

    摘要翻译： 用于局部施用于皮肤的水性制剂，包括水，水混溶性有机溶剂和过氧化苯甲酰，其中有机溶剂的浓度足以提供过氧化苯甲酰在水性制剂中的稳定悬浮液，而不包含表面活性剂 在制剂中，其中制剂中水和有机溶剂的浓度的比例足以在施用于皮肤后将过氧化苯甲酰保持在制剂中饱和溶解度，并且其中制剂中过氧化苯甲酰的浓度小于5.0 ％和至少1.0％w / w。 制剂还可以含有除了过氧化苯甲酰之外的化学化合物，其有效治疗痤疮。 本发明的水性制剂可用于治疗痤疮和痤疮性红斑痤疮。

    Transdermal drug delivery using a dual permeation enhancer and method of performing the same
    4.
    发明授权
    Transdermal drug delivery using a dual permeation enhancer and method of performing the same 失效
    使用双重渗透增强剂的透皮药物递送及其执行方法

    公开(公告)号：US4956171A

    公开(公告)日：1990-09-11

    申请号：US384342

    申请日：1989-07-21

    申请人： Yunik Chang

    发明人： Yunik Chang

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/14 ,  A61K47/26

    CPC分类号： A61K9/7053 ,  A61K47/14 ,  A61K47/26 ,  A61K9/0014 ,  A61K9/7061 ,  A61K9/7084 ,  Y10S514/946

    摘要： A transdermal drug delivery system with a dual permeation enhancer is described. The transdermal system comprises a body that contains supplies of drug and a dual permeation enhancer comprising sucrose cocoate and methyl laurate, and has a basal surface that contacts an area of skin and transmits the drug and the dual permeation enhancer to the area for absorption thereby. A method for coadministering a drug and a dual permeation enhancer comprising sucrose cocoate and methyl laurate is also described.

    摘要翻译： 描述了具有双重渗透增强剂的透皮药物递送系统。 透皮系统包括含有药物供应的身体和包含蔗糖椰子酸酯和月桂酸甲酯的双重渗透增强剂，并且具有接触皮肤区域的基底表面，并将药物和双重渗透促进剂传递到用于吸收的区域。 还描述了一种共纳入药物和包含蔗糖椰子酸酯和月桂酸甲酯的双重渗透增强剂的方法。

    MEDICAMENT FOR THE TREATMENT OF VIRAL SKIN AND TUMOUR DISEASES
    5.
    发明申请
    MEDICAMENT FOR THE TREATMENT OF VIRAL SKIN AND TUMOUR DISEASES 有权
    用于治疗病毒性皮肤病和肿瘤病的药物

    公开(公告)号：US20110009481A1

    公开(公告)日：2011-01-13

    申请号：US12887250

    申请日：2010-09-21

    申请人： Yunik Chang ,  Robert Lathrop ,  Erwin Böhm ,  Irene Gander-Meisterernst ,  Regina Greger ,  Johanna Holldack ,  Ulrich Moebius

    发明人： Yunik Chang ,  Robert Lathrop ,  Erwin Böhm ,  Irene Gander-Meisterernst ,  Regina Greger ,  Johanna Holldack ,  Ulrich Moebius

    IPC分类号： A61K31/353 ,  A61P35/00 ,  A61P17/00

    CPC分类号： A61K9/0014 ,  A61K31/23 ,  A61K31/353 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  Y10S514/934 ,  Y10S514/947 ,  Y10S514/967 ,  Y10S514/969 ,  A61K2300/00

    摘要： The invention relates to a medicament containing a compound of general formula (I), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m-O]nH group with n=1 to 10, preferably n=1 to 5, to m=1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2—R3]- group, where R3=independently H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.

    摘要翻译： 本发明涉及含有通式（I）化合物的药物，其中R 1独立地为直链或支链的，饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基，优选C1- C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m O] n H基，优选n = 1至5，m = 1至5，优选m = 1至3，-CH 2 - [CH-（OH）] p [CH 2 -R 3] - 基，其中R 3独立地为H或OH，p = 7，优选p = 1〜4，戊糖基或己糖基作为治疗活性剂，单独或与一种或几种其它药剂组合，作为tre的组合制剂 特别是由人乳头瘤病毒（HPV）和/或疱疹病毒和局部作用的药物制剂引起的病毒性皮肤病和/或肿瘤疾病的发生及其用途。

    TOPICAL PHARMACEUTICAL FORMULATIONS CONTAINING A LOW CONCENTRATION OF BENZOYL PEROXIDE IN SUSPENSION IN WATER AND A WATER-MISCIBLE ORGANIC SOLVENT
    10.
    发明申请
    TOPICAL PHARMACEUTICAL FORMULATIONS CONTAINING A LOW CONCENTRATION OF BENZOYL PEROXIDE IN SUSPENSION IN WATER AND A WATER-MISCIBLE ORGANIC SOLVENT 有权
    含有过氧化苯甲酰的低浓度在水中的悬浮液和水不溶性有机溶剂的局部药物制剂

    公开(公告)号：US20130012460A1

    公开(公告)日：2013-01-10

    申请号：US13613401

    申请日：2012-09-13

    申请人： Yunik Chang ,  Gordon J. Dow

    发明人： Yunik Chang ,  Gordon J. Dow

    IPC分类号： A61K31/327 ,  A61K31/7056 ,  A61P17/10

    CPC分类号： A61K31/7056 ,  A61K8/0241 ,  A61K8/042 ,  A61K8/044 ,  A61K8/345 ,  A61K8/38 ,  A61K8/55 ,  A61K9/0014 ,  A61K9/14 ,  A61K31/075 ,  A61K31/235 ,  A61K31/327 ,  A61K45/06 ,  A61K47/10 ,  A61K47/32 ,  A61K2800/33 ,  A61K2800/413 ,  A61Q19/00 ,  A61K2300/00

    摘要： An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following, application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.

    摘要翻译： 用于局部施用于皮肤的水性制剂，包括水，水混溶性有机溶剂和过氧化苯甲酰，其中有机溶剂的浓度足以提供过氧化苯甲酰在水性制剂中的稳定悬浮液，而不包含表面活性剂 在制剂中，其中制剂中水和有机溶剂的浓度的比例足以将过氧化苯甲酰保持在制剂中的饱和溶解度，适用于皮肤，并且其中制剂中过氧化苯甲酰的浓度小于 5.0％和至少1.0％w / w。 制剂还可以含有除了过氧化苯甲酰之外的化学化合物，其有效治疗痤疮。 本发明的水性制剂可用于治疗痤疮和痤疮性红斑痤疮。