公开(公告)号：US06767418B1

公开(公告)日：2004-07-27

申请号：US09551171

申请日：2000-04-17

申请人： Tao Zhang ,  Kazuya Sato ,  Kei Kurosaka ,  Yuzi Ogata ,  Xinmin Wang ,  Takashi Kaneko ,  Yuu Kasori

发明人： Tao Zhang ,  Kazuya Sato ,  Kei Kurosaka ,  Yuzi Ogata ,  Xinmin Wang ,  Takashi Kaneko ,  Yuu Kasori

IPC分类号： C22C1400

CPC分类号： A61L27/306 ,  A61L27/06 ,  A61L31/022 ,  A61L31/18 ,  Y10S623/90

摘要： A Ti—Zr type alloy manifesting excellent plastic workability at normal temperature fit for the use in general industry, allowing improvement in corrosion resistance fit for the use in medical treatment, offering improved corrosion resistance in an acidic solution, particularly a HCl solution, and having flexibility as evinced by a low Young's modulus on a par with a bone; and a medical appliance such as a guide wire to be directly inserted into a blood vessel of a human body under the X-ray fluoroscopy and a stent retained in a human body for a long time, which are made of the Ti—Zr type alloy are provided. The Ti—Zr type alloy of the present invention consists of 25 to 50% by weight of Ti, 25 to 60% by weight of Zr, 5 to 30% by weight of Nb, and 5 to 40% by weight of Ta, provided that the weight ratio of Zr to Ti be in the range of 0.5 to 1.5 and the weight ratio of Nb to Ta be in the range of 0.125 to 1.5. The medical appliance of the present invention comprises a part formed of a Ti—Zr type alloy which consists of 25 to 50% by weight of Ti, 25 to 60% by weight of Zr, 5 to 30% by weight of Nb, and 5 to 40% by weight of Ta, provided that the weight ratio of Zr to Ti fall in the range of 0.5 to 1.5 and the weight ratio of Nb to Ta fall in the range of 0.125 to 1.5.

摘要翻译： 在普通工业中适用于普通工业的具有优异塑性加工性能的Ti-Zr型合金，可提高适用于医疗用途的耐腐蚀性，在酸性溶液，特别是HCl溶液中提供改善的耐腐蚀性，并具有 灵活性由与骨骼相当的低杨氏模量所证明; 以及在X射线荧光透视下直接插入人体的血管中的导线等医疗用具，长时间保持在人体内的支架，其由Ti-Zr型合金 被提供。 本发明的Ti-Zr型合金由25〜50重量％的Ti，25〜60重量％的Zr，5〜30重量％的Nb和5〜40重量％的Ta组成， Zr与Ti的重量比在0.5〜1.5的范围内，Nb与Ta的重量比在0.125〜1.5的范围。 本发明的医疗器具包括由Ti-Zr型合金形成的部分，其由25〜50重量％的Ti，25〜60重量％的Zr，5〜30重量％的Nb和5 至40重量％，条件是Zr与Ti的重量比落在0.5至1.5的范围内，Nb与Ta的重量比落在0.125至1.5的范围内。

公开(公告)号：US06495101B1

公开(公告)日：2002-12-17

申请号：US09168105

申请日：1998-10-08

申请人： Kenji Yokoyama ,  Takao Anzai ,  Atsuo Okumura ,  Yuu Kasori

发明人： Kenji Yokoyama ,  Takao Anzai ,  Atsuo Okumura ,  Yuu Kasori

IPC分类号： A61M114

CPC分类号： B01D67/0088 ,  B01D63/021 ,  B01D63/025 ,  Y10S128/23 ,  Y10S261/28

摘要： A hollow fiber membrane oxygenator of external blood circulation type has a housing and a lot of porous hollow fiber membranes for gas transfer housed in the housing. In the oxygenator, blood flows along the outer side of the hollow fiber membranes, whereas oxygen-containing gas flows along the inner side thereof. An outer surface or outer layer of the hollow fiber membrane as a blood-contacting portion is coated with synthetic polymer mainly formed of alkoxyalkyl(meta)acrylate containing a C(1-4)alkoxy group and a C(1-4)alkyl group. An intermediate layer and inner layer of the hollow fiber membranes contain substantially no synthetic polymer.

摘要翻译： 外部血液循环型中空纤维膜氧合器具有容纳在壳体中的壳体和大量用于气体传递的多孔中空纤维膜。 在氧合器中，血液沿着中空纤维膜的外侧流动，而含氧气体沿着其内侧流动。 作为血液接触部分的中空纤维膜的外表面或外层涂覆有主要由含有C（1-4）烷氧基和C（1-4）烷基的烷氧基烷基（甲基）丙烯酸酯形成的合成聚合物 。 中空纤维膜的中间层和内层基本上不含合成聚合物。