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    Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
    4.
    发明授权
    Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 有权
    某些三氟甲基取代的醇的立体选择性合成

    公开(公告)号：US07507843B2

    公开(公告)日：2009-03-24

    申请号：US10955165

    申请日：2004-09-30

    申请人： Jinhua J. Song ,  Zhulin Tan ,  Jinghua Xu ,  Nathan K. Yee ,  Chris H. Senanayake

    发明人： Jinhua J. Song ,  Zhulin Tan ,  Jinghua Xu ,  Nathan K. Yee ,  Chris H. Senanayake

    IPC分类号： C07D301/27

    CPC分类号： C07D303/22

    摘要： A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.

    摘要翻译： 用于立体选择性合成式X化合物的方法，其中：R 1是芳基或杂芳基，各自任选地独立地被1至3个取代基取代，其中R 1的每个取代基独立地是C 1 -C 5烷基，C 2 -C 5烯基，C 2 -C 5炔基，C 3 -C 8环烷基，杂环基，芳基，杂芳基，C 1 -C 5烷氧基，C 2 -C 5烯氧基，C 2 -C 5炔氧基，芳氧基，C 1 -C 5烷酰氧基，C 1 -C 5烷酰基，芳酰基，三氟甲基，三氟甲氧基或C 1 -C 5烷硫基，其中R 1的每个取代基任选地被一至三个选自甲基，甲氧基，氟，氯，羟基，氧代，氰基或氨基的取代基独立地取代。 并且R 2和R 3各自独立地为氢或C 1 -C 5烷基，或者R 2和R 3与它们通常连接的碳原子一起形成C 3 -C 8螺环烷基环。