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    CELL-BASED METHODS FOR DETECTING AND/OR MEASURING BMP-12-RELATED PROTEIN ACTIVITY
    1.
    发明申请
    CELL-BASED METHODS FOR DETECTING AND/OR MEASURING BMP-12-RELATED PROTEIN ACTIVITY 审中-公开
    用于检测和/或测量BMP-12相关蛋白活性的基于细胞的方法

    公开(公告)号：US20090220983A1

    公开(公告)日：2009-09-03

    申请号：US12393628

    申请日：2009-02-26

    申请人： Joanne Archambault ,  Stephen Berasi ,  Andrew Dorner ,  Scott Jelinsky

    发明人： Joanne Archambault ,  Stephen Berasi ,  Andrew Dorner ,  Scott Jelinsky

    IPC分类号： C12Q1/68 ,  C12Q1/02 ,  G01N33/567 ,  G01N33/573

    CPC分类号： C12Q1/6886 ,  C12Q2600/158

    摘要： The invention provides cell-based methods to detect and/or measure the BMP-12-related protein activity of a sample containing a BMP-12-related protein. The methods involve contacting a suitable cell with the sample, and measuring the expression level of at least one BMP-12-related-activity-marker. A dose-dependent increase(s) in the level(s) of the BMP-12-related-activity-markers is indicative of the BMP-12-related protein activity in the sample. The levels of the BMP-12-related-activity-markers of the invention exhibit a dose-responsive increase in response to known BMP-12-related proteins BMP-12, BMP-13, and MP-52, but not to the osteogenic protein, BMP-2.

    摘要翻译： 本发明提供用于检测和/或测量含有BMP-12相关蛋白的样品的BMP-12相关蛋白活性的基于细胞的方法。 所述方法包括使合适的细胞与样品接触，并测量至少一种BMP-12相关活性标记物的表达水平。 BMP-12相关活性标志物水平的剂量依赖性增加指示样品中BMP-12相关的蛋白质活性。 本发明的BMP-12相关活性标志物的水平对已知的BMP-12相关蛋白BMP-12，BMP-13和MP-52的响应性呈现剂量响应性增加，但对成骨 蛋白质，BMP-2。