公开(公告)号：US20240218432A1

公开(公告)日：2024-07-04

申请号：US18287560

申请日：2022-04-20

Applicant: 10x Genomics, Inc.

Inventor： Paulius Mielinis

IPC: C12Q1/6841

CPC classification number: C12Q1/6841

Abstract: Provided herein are methods of testing a biological sample for efficacy of detection of a target nucleic acid where the method includes RNA templated ligation including generating a sequence that is complementary to the hybridized ligation product that includes labelled nucleotides and detecting a signal corresponding to the ligation product on the substrate, thereby determining the efficacy of detection of the target nucleic acid.

公开(公告)号：US20230287481A1

公开(公告)日：2023-09-14

申请号：US18324720

申请日：2023-05-26

Applicant: 10x Genomics, Inc.

Inventor： Anna-Maria Katsori ,  Christina Galonska ,  Paulius Mielinis ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6874

CPC classification number: C12Q1/6837 ,  C12Q1/6874

Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids fragmented with a transposase enzyme, optionally complexed to an antibody-binding moiety (e.g., an antibody-binding protein) bound to an antibody for at least one chromatin protein, in a biological sample.

公开(公告)号：US20230175045A1

公开(公告)日：2023-06-08

申请号：US18074081

申请日：2022-12-02

Applicant: 10x Genomics, Inc.

Inventor： Anna-Maria Katsori ,  Christina Galonska ,  Paulius Mielinis ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6874

CPC classification number: C12Q1/6837 ,  C12Q1/6874

Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids fragmented with a transposase enzyme, optionally complexed to an antibody-binding moiety (e.g., an antibody-binding protein) bound to an antibody for at least one chromatin protein, in a biological sample.

公开(公告)号：US20230313279A1

公开(公告)日：2023-10-05

申请号：US18023963

申请日：2021-09-16

Applicant: 10x Genomics, Inc.

Inventor： Stefania Giacomello ,  Paulius Mielinis ,  Marlon Stoeckius

IPC: C12Q1/6841 ,  C12Q1/6874

CPC classification number: C12Q1/6841 ,  C12Q1/6874 ,  C12Q2600/16 ,  C12Q1/6876

Abstract: Provided herein are methods of determining a location of an analyte in a biological sample and devices that include a plurality of wells, where a well of the plurality of wells comprises a surface comprising a plurality of capture probes.