公开(公告)号：US11203151B2

公开(公告)日：2021-12-21

申请号：US15945435

申请日：2018-04-04

Applicant: 3D SYSTEMS, INC.

Inventor： Ricardo Solorzano ,  Eza Koch ,  Guillaume Robitaille-Beaumier

IPC: B29C64/209 ,  A61L27/52 ,  B29C64/106 ,  B29C64/112 ,  B29C64/295 ,  B33Y30/00 ,  C12M3/00 ,  C12N5/00 ,  C12N5/071 ,  B29C64/336 ,  B29C64/25

Abstract: The present invention relates to a three-dimensional bioprinter for printing and/or patterning a single type or multiple types of cells into different geometrical arrangements and other three-dimensional structures, such as tissues. The bioprinter comprises multiple heads that can each be loaded with a different cartridge containing a biomaterial or biological material such as cells in a solution or cells in a hydrogel. Each bioprinter head and cartridge has the ability to heat or cool using Peltier technology. The bioprinter also has the ability to auto calibrate on a bed plate configured to accept a petri dish or microtiter plate.

公开(公告)号：US12296529B2

公开(公告)日：2025-05-13

申请号：US17341872

申请日：2021-06-08

Applicant: 3D SYSTEMS, INC.

Inventor： Taciana Leticia Woellner Duarte Pereira ,  Thomas Castner ,  Madeline Winter ,  Ricardo Solorzano

IPC: B29C64/00 ,  B29C64/112 ,  B29C64/209 ,  B29C64/245 ,  B29C64/255 ,  B29C64/264 ,  B29C64/386 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00

Abstract: Disclosed are systems and methods for a bioprinter capable of printing an object having biological components. In some embodiments, the bioprinter includes a modular print bed having a recessed area configured to receive a variable insert and a printer head positioned above the modular print bed. In some embodiments, the printer head has a cartridge for receiving and holding a biomaterial, and an extruder configured to extrude biomaterials from the cartridge onto a portion of the variable insert. The variable insert may include functional elements (e.g., heating, cooling, photocuring) and/or receiving elements (e.g., well plates).

公开(公告)号：US11872745B2

公开(公告)日：2024-01-16

申请号：US16450610

申请日：2019-06-24

Applicant: 3D SYSTEMS, INC.

Inventor： Taciana Leticia Woellner Duarte Pereira ,  Ricardo Solorzano ,  Gabriel David Montoya ,  Margaret Elizabeth Prendergast

IPC: B29C64/112 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/245 ,  B29C64/314 ,  B29B13/08 ,  B33Y40/10 ,  B29K83/00 ,  B33Y80/00 ,  B29L31/40 ,  B29K105/00

CPC classification number: B29C64/112 ,  B29B13/08 ,  B29C64/245 ,  B29C64/314 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/10 ,  B33Y70/00 ,  B29K2083/00 ,  B29K2105/0061 ,  B29L2031/40 ,  B33Y80/00

Abstract: Systems and methods for the dispensing of liquid, and automated layering of liquid hydrogel patterns are disclosed. In some embodiments, the systems and methods described herein may utilize a bioprinter having a brush that is configured to pattern a collagen layer. In some embodiments, the bioprinter may be used to make layered bioprinted materials. In some embodiments, the systems and methods described herein may include a bioprinter having an atomizer needle that is configured to dispense liquid in an automated way. In some embodiments, the disclosed systems and methods may provide modified surfaces upon which materials may be printed using a three-dimensional (3D) bioprinter. In one embodiment, a modified surface may be formed of polydimethylsiloxane (PDMS), silicones and the like.