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公开(公告)号：US20230003737A1
公开(公告)日：2023-01-05
申请号：US17901986
申请日：2022-09-02
发明人： David Younger , David Colby , Randolph Lopez , Michael Wittekind
摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
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公开(公告)号：US11466265B2
公开(公告)日：2022-10-11
申请号：US17516237
申请日：2021-11-01
申请人： A-Alpha Bio, Inc.
发明人： David Younger , Randolph Lopez , Arpita Sen , Ryan Emerson
摘要： Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.
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公开(公告)号：US20240363194A1
公开(公告)日：2024-10-31
申请号：US18764600
申请日：2024-07-05
申请人： A-Alpha Bio
发明人： Ryan Emerson , Randolph Lopez , David Younger
CPC分类号： G16B15/30 , C12N15/1037 , G16B35/20
摘要： The present disclosure provides methods for improving libraries for screening protein-protein interactions (PPI) by excluding amino acid substitutions that are predicted to have a redundant or minimal effect on binding between protein binding partners.
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公开(公告)号：US11726097B2
公开(公告)日：2023-08-15
申请号：US17901986
申请日：2022-09-02
申请人： A-Alpha Bio, Inc.
发明人： David Younger , David Colby , Randolph Lopez , Michael Wittekind
CPC分类号： G01N33/6845 , C12N1/16 , C12N15/102 , C12N15/1037 , C12N15/1055 , C12N15/81 , C12N2800/102
摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
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公开(公告)号：US20220380754A1
公开(公告)日：2022-12-01
申请号：US17607801
申请日：2021-04-13
申请人： A-Alpha Bio, Inc.
发明人： David Younger , Randolph Lopez
摘要： Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.
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公开(公告)号：US20240360439A1
公开(公告)日：2024-10-31
申请号：US18291791
申请日：2022-09-09
申请人： A-Alpha Bio, Inc.
发明人： David Younger , Randolph Lopez , Ryan Emerson
IPC分类号： C12N15/10
CPC分类号： C12N15/1068
摘要： Provided are methods for resolving the relationship between unique user-designed and/or random synthetic DNA barcodes and a protein-coding mutated region of interest with enhanced accuracy that is amenable to short-read sequencing platforms. In addition, the methods introduce increased sequence divergence between mutational variants of a region of interest in order to enhance the resolvability of mutational variants within a mutagenic library when error-prone long-read sequencing platforms are used.
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公开(公告)号：US20240309358A1
公开(公告)日：2024-09-19
申请号：US18423075
申请日：2024-01-25
申请人： A-Alpha Bio, Inc.
发明人： David Younger , Randolph Lopez , Ryan Emerson
IPC分类号： C12N15/10
CPC分类号： C12N15/1065
摘要： Provided are methods for resolving the relationship between unique user-designed and/or random synthetic DNA barcodes and a protein-coding mutated region of interest with enhanced accuracy that is amenable to short-read sequencing platforms. In addition, the methods introduce increased sequence divergence between mutational variants of a region of interest in order to enhance the resolvability of mutational variants within a mutagenic library when error-prone long-read sequencing platforms are used.
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公开(公告)号：US20220107326A1
公开(公告)日：2022-04-07
申请号：US17553259
申请日：2021-12-16
发明人： David Younger , David Colby , Randolph Lopez , Michael Wittekind
IPC分类号： G01N33/68
摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
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公开(公告)号：US11474111B2
公开(公告)日：2022-10-18
申请号：US17553259
申请日：2021-12-16
发明人： David Younger , David Colby , Randolph Lopez , Michael Wittekind
摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
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公开(公告)号：US20220251543A1
公开(公告)日：2022-08-11
申请号：US17619506
申请日：2021-06-01
发明人： David Younger , David Colby , Randolph Lopez , Michael Wittekind
摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.
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