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公开(公告)号：US20190062305A1
公开(公告)日：2019-02-28
申请号：US15761735
申请日：2016-09-21
发明人： Gisela BACKFISCH , Margaretha BAKKER , Günter BLAICH , Wilfried BRAJE , Karla DRESCHER , Thomas ERHARD , Andreas HAUPT , Carolin HOFT , Andreas KLING , Viktor LAKICS , Helmut MACK , Frank OELLIEN , Raimund PETER , Frauke POHLKI , Ana Lucia RELO
IPC分类号： C07D401/12 , C07D401/14
摘要： The present invention relates to pyridyl or pyrazinyl compounds carrying a methyl-bound N-amide moiety derived from an α-amino acid of formula I where the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, and to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of the 5-HT2C receptor.
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公开(公告)号：US20170158693A1
公开(公告)日：2017-06-08
申请号：US15435553
申请日：2017-02-17
发明人： Gisela BACKFISCH , Margaretha Henrica Maria BAKKER , Günter BLAICH , Wilfried BRAJE , Karla DRESCHER , Thomas ERHARD , Andreas HAUPT , Hannes KOOLMAN , Viktor LAKICS , Anna LINSENMEIER , Helmut MACK , Raimund PETER , Ana Lucia RELO , Xiaona ZHAO , Jincheng WANG
IPC分类号： C07D471/06
CPC分类号： C07D471/06 , C07D471/04
摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.
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公开(公告)号：US20170112851A1
公开(公告)日：2017-04-27
申请号：US15397902
申请日：2017-01-04
发明人： Gisela BACKFISCH , Margaretha Henrica Maria BAKKER , Günter BLAICH , Wilfried BRAJE , Karla DRESCHER , Thomas ERHARD , Andreas HAUPT , Viktor LAKICS , Anna LINSENMEIER , Helmut MACK , Raimund PETER , Ana Lucia RELO , Lynette SMITH
IPC分类号： A61K31/5513
CPC分类号： A61K31/5513 , C07D471/04 , C07D471/18
摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.
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公开(公告)号：US20180339996A1
公开(公告)日：2018-11-29
申请号：US15778597
申请日：2016-11-24
发明人： Gisela BACKFISCH , Margaretha Henrica Maria BAKKER , Günter BLAICH , Wilfried BRAJE , Karla DRESCHER , Thomas ERHARD , Andreas HAUPT , Carolin HOFT , Viktor LAKICS , Helmut MACK , Frank OELLIEN , Raimund PETER , Ana Lucia RELO
IPC分类号： C07D498/04 , C07D498/14
摘要： The present invention relates to compound of formula (I) (I) wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：US20150259346A1
公开(公告)日：2015-09-17
申请号：US14657916
申请日：2015-03-13
发明人： Gisela BACKFISCH , Margaretha Henrica Maria BAKKER , Günter BLAICH , Wilfried BRAJE , Karla DRESCHER , Thomas ERHARD , Andreas HAUPT , Viktor LAKICS , Anna LINSENMEIER , Helmut MACK , Raimund PETER , Ana Lucia RELO , Lynette SMYTH
IPC分类号： C07D471/18
CPC分类号： A61K31/5513 , C07D471/04 , C07D471/18
摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.
摘要翻译： 本发明涉及携带取代烷基的三环六氢二氮杂喹啉，其制备方法，含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用途 制备用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的药物，用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的方法，以及制备这种化合物的方法 和组合物。
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公开(公告)号：US20150259343A1
公开(公告)日：2015-09-17
申请号：US14657840
申请日：2015-03-13
发明人： Gisela BACKFISCH , Margaretha Henrica Maria BAKKER , Günter BLAICH , Wilfried BRAJE , Karla DRESCHER , Thomas ERHARD , Andreas HAUPT , Hannes KOOLMAN , Viktor LAKICS , Anna LINSENMEIER , Helmut MACK , Raimund PETER , Ana Lucia RELO
IPC分类号： C07D471/06
CPC分类号： C07D471/06 , C07D471/04
摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.
摘要翻译： 本发明涉及携带环状取代基的三环六氢二氮杂喹啉，其制备方法，含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备 用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的药物，用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法，以及制备这种化合物的方法和 组合物。
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