公开(公告)号：US09181572B2

公开(公告)日：2015-11-10

申请号：US13830976

申请日：2013-03-14

Applicant: ABBVIE INC.

Inventor： Kartik Subramanian ,  Mayda Perez ,  Xiaobei Zeng ,  Chee Furng Wong ,  Christopher Chumsae

IPC: C12P21/08 ,  C12P21/00 ,  C07K16/00 ,  C07K16/28 ,  C12N5/00

CPC classification number: C07K16/241 ,  C07K16/00 ,  C07K16/2803 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/40 ,  C07K2317/526 ,  C12N5/0018 ,  C12N2500/22 ,  C12N2500/32 ,  C12N2511/00 ,  C12P21/00

Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.

Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制由宿主细胞表达的赖氨酸变体的分布或数量的组合物和方法，以及用于控制宿主细胞中存在的赖氨酸变体的量的组合物和方法 纯化制剂。

公开(公告)号：US20130280274A1

公开(公告)日：2013-10-24

申请号：US13830976

申请日：2013-03-14

Applicant: ABBVIE INC.

Inventor： Kartik Subramanian ,  Mayda Perez ,  Xiaobei Zeng ,  Chee Furng Wong

IPC: C12P21/00

CPC classification number: C07K16/241 ,  C07K16/00 ,  C07K16/2803 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/40 ,  C07K2317/526 ,  C12N5/0018 ,  C12N2500/22 ,  C12N2500/32 ,  C12N2511/00 ,  C12P21/00

Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.

Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制由宿主细胞表达的赖氨酸变体的分布或数量的组合物和方法，以及用于控制宿主细胞中存在的赖氨酸变体的量的组合物和方法 纯化制剂。