QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OR PREVENTION OF VIRAL INFECTION

    公开(公告)号:US20180028522A1

    公开(公告)日:2018-02-01

    申请号:US15552921

    申请日:2016-02-19

    IPC分类号: A61K31/47 A61K31/706

    摘要: The present invention relates to a quinoline derivative of formula (I) or anyone of its pharmaceutically acceptable salt, or anyone of its metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient; and then terminating said treatment when: the viral load is low or undetectable; and/or the level of CD4+ cell count is maintained or restored. The present invention further relates to a quinoline derivative of formula (I) as defined in claim 1, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, for which an ineffectiveness or a decline in a prior anti-retroviral treatment effectiveness has been stated and to a quinoline derivative of formula (I) as defined above, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, wherein the patient is infected by a drug-resistant viral strain, and more particularly by a drug-resistant HIV strain.

    COMPOUNDS USEFUL FOR TREATING AIDS
    6.
    发明申请
    COMPOUNDS USEFUL FOR TREATING AIDS 有权
    用于治疗艾滋病的化合物

    公开(公告)号:US20140288120A1

    公开(公告)日:2014-09-25

    申请号:US14256334

    申请日:2014-04-18

    IPC分类号: C07D401/12

    摘要: A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R″ is a hydrogen atom or a (C1-C4)alkyl group; n′ is 1 or 2; n is 1, 2, or 3; R independently represents a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —NR1R2 group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a (C1-C3)fluoroalkoxy, and a (C1-C4)alkoxy group; R′ is a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a (C1-C4)alkoxy group, and a CN group; R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group; with the proviso that when R and R′ are not simultaneously a hydrogen atom: when n is 1, R is not a methyl group in an ortho or para position with respect to N, when R′ is a hydrogen atom, R is not a bromine atom or a chlorine atom, and when R is a hydrogen atom, R is not a methyl or ethyl group, a —COOH group, a —COOC2H5 group, or a bromine atom that is in an ortho position of the bond linked to NR″.

    摘要翻译: 具有下式的化合物或其药学上可接受的盐:其中:R“是氢原子或(C 1 -C 4)烷基; n'为1或2; n为1,2或3; R独立地表示氢原子,卤素原子或选自(C1-C3)烷基,-CN基,羟基,-NR1R2基,-COOR1基,(C1-C3) 氟烷基,-NO 2基,(C1-C3)氟烷氧基和(C1-C4)烷氧基; R'是氢原子,卤素原子或选自(C1-C3)烷基,-COOR1基,-NO2基,-NR1R2基,(C1-C4)烷氧基的基团和 CN组; R1和R2是氢原子或(C1-C3)烷基; 条件是当R和R'不同时为氢原子时:当n为1时,当R'为氢原子时,R不为相对于N的邻位或对位的甲基,R不为 溴原子或氯原子,当R为氢原子时,R不是甲基或乙基,-COOH基团,-COOC2H5基团或与NR键合的邻位的溴原子 “。