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    COMPOUNDS USEFUL FOR TREATING AIDS
    1.
    发明申请
    COMPOUNDS USEFUL FOR TREATING AIDS 有权
    用于治疗艾滋病的化合物

    公开(公告)号：US20140288120A1

    公开(公告)日：2014-09-25

    申请号：US14256334

    申请日：2014-04-18

    申请人： SOCIETE SPLICOS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  UNIVERSITE MONTPELLIER 2

    发明人： Jamal TAZI ,  Florence MAHUTEAU ,  Romain NAJMAN ,  Didier SCHERRER ,  Noelie CAMPOS ,  Aude GARCEL

    IPC分类号： C07D401/12

    CPC分类号： C07D403/12 ,  A61K31/4709 ,  A61K31/4985 ,  C07D213/74 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D241/44 ,  C07D401/12

    摘要： A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R″ is a hydrogen atom or a (C1-C4)alkyl group; n′ is 1 or 2; n is 1, 2, or 3; R independently represents a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —NR1R2 group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a (C1-C3)fluoroalkoxy, and a (C1-C4)alkoxy group; R′ is a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a (C1-C4)alkoxy group, and a CN group; R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group; with the proviso that when R and R′ are not simultaneously a hydrogen atom: when n is 1, R is not a methyl group in an ortho or para position with respect to N, when R′ is a hydrogen atom, R is not a bromine atom or a chlorine atom, and when R is a hydrogen atom, R is not a methyl or ethyl group, a —COOH group, a —COOC2H5 group, or a bromine atom that is in an ortho position of the bond linked to NR″.

    摘要翻译： 具有下式的化合物或其药学上可接受的盐：其中：R“是氢原子或（C 1 -C 4）烷基; n'为1或2; n为1,2或3; R独立地表示氢原子，卤素原子或选自（C1-C3）烷基，-CN基，羟基，-NR1R2基，-COOR1基，（C1-C3） 氟烷基，-NO 2基，（C1-C3）氟烷氧基和（C1-C4）烷氧基; R'是氢原子，卤素原子或选自（C1-C3）烷基，-COOR1基，-NO2基，-NR1R2基，（C1-C4）烷氧基的基团和 CN组; R1和R2是氢原子或（C1-C3）烷基; 条件是当R和R'不同时为氢原子时：当n为1时，当R'为氢原子时，R不为相对于N的邻位或对位的甲基，R不为 溴原子或氯原子，当R为氢原子时，R不是甲基或乙基，-COOH基团，-COOC2H5基团或与NR键合的邻位的溴原子 “。

    QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OR PREVENTION OF VIRAL INFECTION
    7.
    发明申请
    QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OR PREVENTION OF VIRAL INFECTION 审中-公开

    公开(公告)号：US20180028522A1

    公开(公告)日：2018-02-01

    申请号：US15552921

    申请日：2016-02-19

    申请人： ABIVAX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  UNIVERSITE DE MONTPELLIER

    发明人： Didier SCHERRER ,  Aude GARCEL ,  Noelie CAMPOS ,  Jamal TAZI ,  Audrey VAUTRIN ,  Florence MAHUTEAU ,  Romain NAJMAN ,  Pauline FORNARELLI

    IPC分类号： A61K31/47 ,  A61K31/706

    摘要： The present invention relates to a quinoline derivative of formula (I) or anyone of its pharmaceutically acceptable salt, or anyone of its metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient; and then terminating said treatment when: the viral load is low or undetectable; and/or the level of CD4+ cell count is maintained or restored. The present invention further relates to a quinoline derivative of formula (I) as defined in claim 1, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, for which an ineffectiveness or a decline in a prior anti-retroviral treatment effectiveness has been stated and to a quinoline derivative of formula (I) as defined above, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, wherein the patient is infected by a drug-resistant viral strain, and more particularly by a drug-resistant HIV strain.

    COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES
    8.
    发明申请
    COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES 有权
    用于治疗由逆转录病毒引起的疾病的化合物

    公开(公告)号：US20160151348A1

    公开(公告)日：2016-06-02

    申请号：US14902935

    申请日：2014-07-04

    申请人： ABIVAX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  UNIVERSITE DE MONTPELLIER

    发明人： Jamal TAZI ,  Florence MAHUTEAU-BETZER ,  Romain NAJMAN ,  Didier SCHERRER ,  Noëlie CAMPOS ,  Aude GARCEL

    IPC分类号： A61K31/4709 ,  A61K31/497 ,  A61K31/498 ,  A61K31/47

    CPC分类号： A61K31/4709 ,  A61K31/47 ,  A61K31/497 ,  A61K31/498 ,  A61K31/506

    摘要： Methods for preventing or treating retroviral infection not HIV and/or for preventing, inhibiting or treating a disease caused by the retroviral infection include contacting a cell with compound (I) wherein: means a pyridazine, pyrimidine or pyrazine group, R independently represent a hydrogen atom, halogen atom or group chosen among a —CN, hydroxyl, —COOR1, (C1-C3)fluoroalkyl, (C1-C3)fluoroalkoxy, —NO2, —NR1R2, (C1-C4)alkoxy, phenoxy and (C1-C3)alkyl group, the alkyl being optionally mono-substituted by hydroxyl group, n is 1, 2 or 3, n′ is 1 or 2, R′ is a hydrogen atom, halogen atom or group chosen among (C1-C3)alkyl group, hydroxyl group, —COOR1 group, —NO2 group, —NR1R2 group, morpholinyl or morpholino group, N-methylpiperazinyl group, (C1-C3)fluoroalkyl group, (C1-C4)alkoxy group and —CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C.

    摘要翻译： 用于预防或治疗逆转录病毒感染而不是HIV和/或用于预防，抑制或治疗由逆转录病毒感染引起的疾病的方法包括使细胞与化合物（I）接触，其中：表示哒嗪，嘧啶或吡嗪基，R独立地表示氢 原子，卤素原子或选自-CN，羟基，-COOR1，（C1-C3）氟烷基，（C1-C3）氟烷氧基，-NO2，-NR1R2，（C1-C4）烷氧基，苯氧基和（C1-C3） ）烷基，烷基任选被羟基单取代，n为1,2或3，n'为1或2，R'为氢原子，卤素原子或选自（C1-C3）烷基中的基团 ，羟基，-COOR1基，-NO2基，-NR1R2基，吗啉基或吗啉基，N-甲基哌嗪基，（C1-C3）氟烷基，（C1-C4）烷氧基和-CN基，Z是N或 C，Y为N或C，X为N或C，W为N或C，T为N或C，U为N或C。