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    QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OR PREVENTION OF VIRAL INFECTION
    6.
    发明申请
    QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OR PREVENTION OF VIRAL INFECTION 审中-公开

    公开(公告)号：US20180028522A1

    公开(公告)日：2018-02-01

    申请号：US15552921

    申请日：2016-02-19

    申请人： ABIVAX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  UNIVERSITE DE MONTPELLIER

    发明人： Didier SCHERRER ,  Aude GARCEL ,  Noelie CAMPOS ,  Jamal TAZI ,  Audrey VAUTRIN ,  Florence MAHUTEAU ,  Romain NAJMAN ,  Pauline FORNARELLI

    IPC分类号： A61K31/47 ,  A61K31/706

    摘要： The present invention relates to a quinoline derivative of formula (I) or anyone of its pharmaceutically acceptable salt, or anyone of its metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient; and then terminating said treatment when: the viral load is low or undetectable; and/or the level of CD4+ cell count is maintained or restored. The present invention further relates to a quinoline derivative of formula (I) as defined in claim 1, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, for which an ineffectiveness or a decline in a prior anti-retroviral treatment effectiveness has been stated and to a quinoline derivative of formula (I) as defined above, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, wherein the patient is infected by a drug-resistant viral strain, and more particularly by a drug-resistant HIV strain.

    COMPOUNDS USEFUL FOR TREATING AIDS
    8.
    发明申请
    COMPOUNDS USEFUL FOR TREATING AIDS 有权
    用于治疗艾滋病的化合物

    公开(公告)号：US20140288120A1

    公开(公告)日：2014-09-25

    申请号：US14256334

    申请日：2014-04-18

    申请人： SOCIETE SPLICOS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  UNIVERSITE MONTPELLIER 2

    发明人： Jamal TAZI ,  Florence MAHUTEAU ,  Romain NAJMAN ,  Didier SCHERRER ,  Noelie CAMPOS ,  Aude GARCEL

    IPC分类号： C07D401/12

    CPC分类号： C07D403/12 ,  A61K31/4709 ,  A61K31/4985 ,  C07D213/74 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D241/44 ,  C07D401/12

    摘要： A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R″ is a hydrogen atom or a (C1-C4)alkyl group; n′ is 1 or 2; n is 1, 2, or 3; R independently represents a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —NR1R2 group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a (C1-C3)fluoroalkoxy, and a (C1-C4)alkoxy group; R′ is a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a (C1-C4)alkoxy group, and a CN group; R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group; with the proviso that when R and R′ are not simultaneously a hydrogen atom: when n is 1, R is not a methyl group in an ortho or para position with respect to N, when R′ is a hydrogen atom, R is not a bromine atom or a chlorine atom, and when R is a hydrogen atom, R is not a methyl or ethyl group, a —COOH group, a —COOC2H5 group, or a bromine atom that is in an ortho position of the bond linked to NR″.

    摘要翻译： 具有下式的化合物或其药学上可接受的盐：其中：R“是氢原子或（C 1 -C 4）烷基; n'为1或2; n为1,2或3; R独立地表示氢原子，卤素原子或选自（C1-C3）烷基，-CN基，羟基，-NR1R2基，-COOR1基，（C1-C3） 氟烷基，-NO 2基，（C1-C3）氟烷氧基和（C1-C4）烷氧基; R'是氢原子，卤素原子或选自（C1-C3）烷基，-COOR1基，-NO2基，-NR1R2基，（C1-C4）烷氧基的基团和 CN组; R1和R2是氢原子或（C1-C3）烷基; 条件是当R和R'不同时为氢原子时：当n为1时，当R'为氢原子时，R不为相对于N的邻位或对位的甲基，R不为 溴原子或氯原子，当R为氢原子时，R不是甲基或乙基，-COOH基团，-COOC2H5基团或与NR键合的邻位的溴原子 “。