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公开(公告)号：US11707533B2
公开(公告)日：2023-07-25
申请号：US16940326
申请日：2020-07-27
发明人： Yun-Hee Park , Ho Young Song , Hyun Min Ryu , Sung Min Kim , Ju Yuel Baek , Ji Hye Oh , Nara Han , Hyoung Rae Kim , Kyung Eun Park , Hyeun Joung Lee , Ju Young Lee , Dae Hyuck Kang , Young-Jae Yang , Ji-Na You , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Jinwon Jung , Juhee Kim , Bora Lee , Daehae Song , Byungje Sung , Donghoon Yeom , Jaehyun Eom , Youngeun Hong , Jinhyung Ahn , Yangsoon Lee , Kyungjin Park , Jiseon Yoo , Minji Park
CPC分类号： A61K47/6849 , A61K47/6803 , A61P35/00 , C07K16/2803
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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公开(公告)号：US20230405139A1
公开(公告)日：2023-12-21
申请号：US18209299
申请日：2023-06-13
发明人： Yun-Hee Park , Ho Young Song , Hyun Min Ryu , Sung Min Kim , Ju Yuel Baek , Ji Hye Oh , Nara Han , Hyoung Rae Kim , Kyung Eun Park , Hyeun Joung Lee , Ju Young Lee , Dae Hyuck Kang , Young-Jae Yang , Ji-na You , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Jinwon Jung , Juhee Kim , Bora Lee , Daehae Song , Byungje Sung , Donghoon Yeom , Jaehyun Eom , Youngeun Hong , Jinhyung Ahn , Yangsoon Lee , Kyungjin Park , Jiseon Yoo , Minji Park
CPC分类号： A61K47/6849 , A61P35/00 , A61K47/6803 , C07K16/2803
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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公开(公告)号：US20140161829A1
公开(公告)日：2014-06-12
申请号：US14181648
申请日：2014-02-15
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
IPC分类号： A61K47/48
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).
摘要翻译： 本发明提供了具有可被类异戊二烯转移酶识别的氨基酸基序的蛋白质 - 活性剂缀合物。 本发明还提供含有缀合物的组合物。 本发明还提供了使用结合物将活性剂递送至靶细胞的方法，以及使用缀合物治疗有此需要的受试者（例如需要活性剂的受试者）的方法。
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公开(公告)号：US20220339291A1
公开(公告)日：2022-10-27
申请号：US16964965
申请日：2020-03-05
发明人： Chang Sik Park , Min Ji Choi , Tae Ik Jang , Yun-Hee Park , Ho Young Song , Ju Yuel Baek , Sung Min Kim , Hyeun Joung Lee , Ju Young Lee , Hyoung Rae Kim , Kun Jung Lee , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Sang Pil Lee , Ji-Young Shin , Sunha Yoon , Yunseon Choi , Jae Eun Park , Jisu Lee , Bum-Chan Park , Young Woo Park
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically, uses for such ADCs in producing drugs for treatment and/or prevention of proliferative and/or angiogenetic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding with DLK1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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公开(公告)号：US10583197B2
公开(公告)日：2020-03-10
申请号：US15612766
申请日：2017-06-02
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).
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公开(公告)号：US20150105541A1
公开(公告)日：2015-04-16
申请号：US14517616
申请日：2014-10-17
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
IPC分类号： A61K47/48
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent)
摘要翻译： 本发明提供了具有可被类异戊二烯转移酶识别的氨基酸基序的蛋白质 - 活性剂缀合物。 本发明还提供含有缀合物的组合物。 本发明还提供了使用结合物将活性剂递送至靶细胞的方法，以及使用缀合物治疗有需要的受试者（例如，需要活性剂的受试者）的方法，
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公开(公告)号：US20140187756A1
公开(公告)日：2014-07-03
申请号：US14181649
申请日：2014-02-15
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agent. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods.
摘要翻译： 本发明提供了制备抗体 - 活性剂缀合物的方法。 缀合物包含抗体，氨基酸基序的半胱氨酸残基，其可被位于抗体的羧基末端或之后的类异戊二烯转移酶识别，与半胱氨酸残基可操作地连接的类异戊二烯单元和活性剂。 本发明还提供包含通过该方法制备的抗体 - 活性剂缀合物的组合物。
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公开(公告)号：US20230270868A1
公开(公告)日：2023-08-31
申请号：US18113948
申请日：2023-02-24
发明人： Ho Young Song , Sung Min Kim , Hyoungrae Kim , Kyung Eun Park , Chul-Woong Chung , Yun-Hee Park , Hyo Jung Choi , Su In Lee , Juyuel Baek , Hyeun Joung Lee , Ju Young Lee , Ji Hye Oh , Jeiwook Chae , Yeong Soo Oh , Yong Zu Kim
CPC分类号： A61K47/552 , A61P35/00
摘要： The present invention relates to a pyrrolobenzodiazepine dimer prodrug and a ligand-linker conjugate compound thereof, a composition containing these, and therapeutic use thereof particularly as an anticancer drug. The stability of the compounds themselves and the stability thereof in plasma are excellent and the compounds are advantageous in terms of manifestation of toxicity, and thus the compounds are industrially useful in that it is possible to target proliferative diseases such as cancer, to perform a specific treatment, to maximize the drug efficacy, and to minimize the occurrence of side effects.
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公开(公告)号：US20200289662A1
公开(公告)日：2020-09-17
申请号：US16812690
申请日：2020-03-09
发明人： YongZu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent)
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公开(公告)号：US09669107B2
公开(公告)日：2017-06-06
申请号：US14517616
申请日：2014-10-17
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).
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