公开(公告)号：US20230338535A1

公开(公告)日：2023-10-26

申请号：US18343349

申请日：2023-06-28

申请人： Janssen Pharmaceuticals, Inc. ,  AC Immune SA

发明人： Andrea Pfeifer ,  Andreas Muhs ,  Wendy Galpern

IPC分类号： A61K39/00 ,  A61K9/127

CPC分类号： A61K39/4637 ,  A61K39/4611 ,  A61K9/1271 ,  A61K2039/55555 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55572 ,  A61K2039/55561 ,  A61K2039/57

摘要： Methods for inducing a sustained immune response against phosphorylated Tau in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist, a helper T-cell epitope, a lipidated CpG oligonucleotide, and a Tau phosphopeptide presented on the surface of the liposome to thereby obtain the sustained immune response.

公开(公告)号：US20230381108A1

公开(公告)日：2023-11-30

申请号：US18316829

申请日：2023-05-12

申请人： AC Immune SA ,  Janssen Pharmaceuticals, Inc.

发明人： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren Bosch ,  Marija Vukicevic Verhille ,  Nicolas Piot ,  Saroj Raj Ghimire ,  Elizabeth Anne Ramsburg ,  Donata De Marco ,  Charlotte Sadaka

IPC分类号： A61K9/127 ,  A61P25/28 ,  A61K39/00

CPC分类号： A61K9/1271 ,  A61P25/28 ,  A61K39/0007 ,  A61K2039/545 ,  A61K2039/627 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/6018 ,  A61K2039/55516

摘要： Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

公开(公告)号：US11684576B2

公开(公告)日：2023-06-27

申请号：US16785011

申请日：2020-02-07

申请人： AC Immune SA ,  Janssen Pharmaceuticals, Inc.

发明人： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren Bosch ,  Marija Vukicevic Verhille ,  Nicolas Piot ,  Saroj Raj Ghimire ,  Elizabeth Anne Ramsburg ,  Donata De Marco ,  Charlotte Sadaka

IPC分类号： A61K9/127 ,  A61P25/28 ,  A61K39/00

CPC分类号： A61K9/1271 ,  A61K39/0007 ,  A61P25/28 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/6018 ,  A61K2039/627

摘要： Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

公开(公告)号：US20240270829A1

公开(公告)日：2024-08-15

申请号：US18395150

申请日：2023-12-22

申请人： AC Immune SA

发明人： Andrea Pfeifer ,  Andreas Muhs ,  Rime Madani ,  Pavel Vasilyevich Belichenko ,  William Charles Mobley

IPC分类号： C07K16/18 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/55555 ,  A61K2039/6018

摘要： The present invention provides means for treating, alleviating and preventing amyloid-related pathology in young to middle-aged subjects with Down's syndrome (DS). In particular, the present invention provides antigenic peptide fragments derived from amyloid protein or amyloid-like protein for use in the preventive treatment of amyloid-related pathology in young to middle-aged subjects with Down's syndrome.

公开(公告)号：US20220226447A1

公开(公告)日：2022-07-21

申请号：US17612921

申请日：2020-05-20

申请人： AC Immune SA

发明人： Andrea Pfeifer ,  Andreas Muhs (Deceased)

IPC分类号： A61K39/00 ,  A61K39/39 ,  A61P25/28

摘要： A liposomal vaccine composition comprising: a. A β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome that comprises, consists essentially of or consists of amino acids 1-15 of Aβ, b. An adjuvant comprising monophosphoryl lipid A (MPLA) is used for inducing an anti-Aβ immune response in a human subject without inducing a serious adverse event. The β-amyloid (Aβ)-derived peptide antigen (SEQ ID NO: 1) is administered in an amount of 300-2000 μg, preferably around 1000 μg. The MPLA is administered in an amount of 15-600 μg, preferably around 175 μg. The liposomal vaccine composition is administered intramuscularly or subcutaneously.