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    METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES
    1.
    发明公开
    METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES 审中-公开

    公开(公告)号：US20230233549A1

    公开(公告)日：2023-07-27

    申请号：US18184364

    申请日：2023-03-15

    Applicant: Academia Sinica

    Inventor： Rong-Jie CHEIN ,  Pan-Chyr YANG ,  Chi-Huey WONG ,  Ming-Shiu LIN ,  Ting-Jen CHENG ,  Ting-Hung Rachel CHOU

    IPC: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

    CPC classification number: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

    Abstract: Provided herein are compounds of Formula (I). The disclosure provides new compounds, compositions, and methods for treating, delaying, and/or preventing the adverse effects of proliferative diseases, such as cancers including, for example, lung cancer, breast cancer, ovarian cancer, prostate cancer, head cancer, neck cancer, head and neck cancer, or leukemia (e.g., cancer resistant to treatment by one or more microtubule-targeting agents (e.g., cancer resistant to multiple drugs associated with P-glycoprotein (P-gp) overexpression)). Provided are methods of inhibiting polymerization of a cancer cell microtubule in a subject in need thereof or a cell, tissue, or biological sample, binding β-tubulin, inhibiting microtubule assembly and, inducing apoptosis in a cancer cell resistant to multiple drugs in a tissue, biological sample, or subject. Also provided in the present disclosure are pharmaceutical compositions, kits, and methods of using the compounds for treating any of the target diseases described herein.

    4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF
    8.
    发明申请
    4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF 审中-公开

    公开(公告)号：US20200330449A1

    公开(公告)日：2020-10-22

    申请号：US16831346

    申请日：2020-03-26

    Applicant: Academia Sinica

    Inventor： Rong-Jie CHEIN ,  Pan-Chyr YANG ,  Chi-Huey WONG ,  Ming-Shiu LIN ,  Ting-Jen CHENG ,  Ting-Hung CHOU

    IPC: A61K31/47 ,  C07D215/233 ,  A61K45/06 ,  A61P35/00

    Abstract: Compounds of Formula (I) and methods for treating, delaying, and/or preventing the adverse effects of proliferative diseases, such as cancers including, for example, lung cancer, breast cancer, ovarian cancer, prostate cancer, head cancer, neck cancer, head and neck cancer, or leukemia (e.g., cancer resistant to treatment by one or more microtubule-targeting agents, e.g., cancer resistant to multiple drugs associated with P-glycoprotein (P-gp) overexpression). Methods of inhibiting polymerization of a cancer cell microtubule in a subject in need thereof or a cell, tissue, or biological sample, binding p-tubulin, inhibiting microtubule assembly and, inducing apoptosis in a cancer cell resistant to multiple drugs in a tissue, biological sample, or subject. Pharmaceutical compositions, kits, and methods of using the compounds for treating any of the target diseases described herein.

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