公开(公告)号：US20160106728A1

公开(公告)日：2016-04-21

申请号：US14787885

申请日：2014-05-01

Applicant: ACADEMIA SINICA

Inventor： Che-Kun James Shen ,  Yu-Chi Chou ,  Tsann-Long Su

IPC: A61K31/473 ,  A61K9/00

CPC classification number: A61K31/473 ,  A61K9/0053 ,  A61K45/06 ,  C07D221/14 ,  G01N33/5044 ,  G01N2333/805 ,  G01N2800/52 ,  A61K2300/00

Abstract: Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.

Abstract translation: 化合物，药物组合物和治疗贫血和地贫贫血或镰状细胞性贫血的方法。

公开(公告)号：US10562976B2

公开(公告)日：2020-02-18

申请号：US16166220

申请日：2018-10-22

Applicant: Academia Sinica

Inventor： An-Suei Yang ,  Wei-Ying Kuo ,  Hung-Ju Hsu ,  Hong-Sen Chen ,  Yu-Chi Chou ,  Yueh-Liang Tsou ,  Hung-Pin Peng ,  Jhih-Wei Jian ,  Chung-Ming Yu ,  Yi-Kai Chiu ,  Ing-Chein Chen ,  Chao-Ping Tung ,  Michael Hsiao ,  Hwei-Jiung Wang

IPC: A61K39/00 ,  A61K39/38 ,  A61K39/395 ,  C07K16/30 ,  A61K47/68 ,  A61P35/00 ,  C07K16/32

Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.

公开(公告)号：US20170290820A1

公开(公告)日：2017-10-12

申请号：US15496883

申请日：2017-04-25

Applicant: Academia Sinica

Inventor： Che-Kun James Shen ,  Yu-Chi Chou ,  Tsann-Long Su

IPC: A61K31/473 ,  G01N33/50 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K31/473 ,  A61K9/0053 ,  A61K45/06 ,  C07D221/14 ,  G01N33/5044 ,  G01N2333/805 ,  G01N2800/52 ,  A61K2300/00

Abstract: Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.

公开(公告)号：US09662324B2

公开(公告)日：2017-05-30

申请号：US14787885

申请日：2014-05-01

Applicant: Academia Sinica

Inventor： Che-Kun James Shen ,  Yu-Chi Chou ,  Tsann-Long Su

IPC: A61K31/473 ,  A61K9/00 ,  A61K45/06 ,  G01N33/50 ,  C07D221/14

CPC classification number: A61K31/473 ,  A61K9/0053 ,  A61K45/06 ,  C07D221/14 ,  G01N33/5044 ,  G01N2333/805 ,  G01N2800/52 ,  A61K2300/00

Abstract: Compounds, pharmaceutical compositions, and methods for treating anemia (β-thalassemia anemia or sickle cell anemia.