公开(公告)号：US11897943B2

公开(公告)日：2024-02-13

申请号：US17397915

申请日：2021-08-09

申请人： ADMA Biologics, Inc.

发明人： James Mond ,  Adam S. Grossman

IPC分类号： C07K16/12 ,  C07K16/06 ,  A61K9/00 ,  A61K35/16

CPC分类号： C07K16/1275 ,  A61K9/0019 ,  A61K35/16 ,  C07K16/06 ,  C07K16/065 ,  C07K2317/10 ,  C07K2317/21

摘要： The present invention relates to compositions and methods for the treatment of infection caused by Streptococcus pneumonia. In particular, the invention provides human hyperimmune globulin and compositions thereof for preventing or treating pneumococcal infection. The invention provides methods of producing hyperimmune globulin containing high titers of opsonophagocytic anti-pneumococcal antibodies, compositions containing same, and methods of using the compositions for the prevention and treatment of pneumococcal infection. The invention further provides methods of preventing or treating pneumococcal infection (e.g., upper respiratory infections (e.g., bronchitis, otitis, sinusitis, etc.)) in immunocompromised subjects via administration of hyperimmune globulin compositions of the invention (e.g., containing a high titer of opsonophagocytic anti-pneumococcal antibodies) to immunocompromised subjects.

公开(公告)号：US20210130441A1

公开(公告)日：2021-05-06

申请号：US16901993

申请日：2020-06-15

申请人： ADMA Biologics, Inc.

发明人： Adam S. Grossman ,  James Mond ,  Jerrold B. Grossman ,  Dov A. Goldstein

IPC分类号： C07K16/06 ,  A61K39/395 ,  A61K39/42 ,  C07K16/08 ,  C07K16/10 ,  A61K39/155 ,  A61K45/06 ,  G01N33/68 ,  C07K16/12

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

公开(公告)号：US09969793B2

公开(公告)日：2018-05-15

申请号：US15811486

申请日：2017-11-13

申请人： ADMA Biologics, Inc.

发明人： Adam S. Grossman ,  James Mond ,  Jerrold B. Grossman ,  Dov A. Goldstein

IPC分类号： A61K39/42 ,  C07K16/06 ,  A61K39/395 ,  A61K45/06 ,  C07K16/08 ,  C07K16/10 ,  C07K16/12 ,  G01N33/68 ,  A61K39/155 ,  A61K39/00

CPC分类号： C07K16/06 ,  A61K39/155 ,  A61K39/39516 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/507 ,  C07K16/08 ,  C07K16/10 ,  C07K16/1009 ,  C07K16/1027 ,  C07K16/1203 ,  C07K16/1232 ,  C07K16/1242 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1282 ,  C07K16/1285 ,  C07K16/1289 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/76 ,  G01N33/6854 ,  Y02A50/466 ,  Y02A50/469

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

公开(公告)号：US20160115221A1

公开(公告)日：2016-04-28

申请号：US14790872

申请日：2015-07-02

申请人： ADMA Biologics, Inc.

发明人： Adam S. Grossman ,  Jerrold B. Grossman ,  James Mond ,  Dov A. Goldstein

IPC分类号： C07K16/06 ,  C07K16/12 ,  C07K16/10

CPC分类号： C07K16/06 ,  A61K39/155 ,  A61K39/39516 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/507 ,  C07K16/08 ,  C07K16/10 ,  C07K16/1009 ,  C07K16/1027 ,  C07K16/1203 ,  C07K16/1232 ,  C07K16/1242 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1282 ,  C07K16/1285 ,  C07K16/1289 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/76 ,  G01N33/6854 ,  Y02A50/466 ,  Y02A50/469

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

公开(公告)号：US20210277093A1

公开(公告)日：2021-09-09

申请号：US17196846

申请日：2021-03-09

申请人： ADMA Biologics, Inc.

发明人： James Mond ,  Adam S. Grossman

IPC分类号： C07K16/10 ,  G01N33/569 ,  A61P31/14 ,  A61K45/06 ,  A61K39/42

摘要： Embodiments of the present disclosure relate generally to compositions and methods for the treatment and/or prevention of pathogenic viral infections, e.g., coronavirus infections. In particular, the present disclosure provides human plasma compositions and immunoglobulin prepared therefrom containing select antibody titers specific for coronavirus (e.g., SARS CoV-2), methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions for prophylactic administration and/or therapeutic treatment (e.g., passive immunization or immune-prophylaxis).

公开(公告)号：US09815886B2

公开(公告)日：2017-11-14

申请号：US14592727

申请日：2015-01-08

申请人： ADMA Biologics, Inc.

发明人： Adam S. Grossman ,  James Mond ,  Jerrold B. Grossman ,  Dov A. Goldstein

IPC分类号： A61K39/42 ,  C07K16/06 ,  A61K39/395 ,  C07K16/08 ,  C07K16/10 ,  A61K45/06 ,  G01N33/68 ,  C07K16/12 ,  A61K39/155 ,  A61K39/00

CPC分类号： C07K16/06 ,  A61K39/155 ,  A61K39/39516 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/507 ,  C07K16/08 ,  C07K16/10 ,  C07K16/1009 ,  C07K16/1027 ,  C07K16/1203 ,  C07K16/1232 ,  C07K16/1242 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1282 ,  C07K16/1285 ,  C07K16/1289 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/76 ,  G01N33/6854 ,  Y02A50/466 ,  Y02A50/469

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

公开(公告)号：US20190241646A1

公开(公告)日：2019-08-08

申请号：US16384334

申请日：2019-04-15

申请人： ADMA Biologics, Inc.

发明人： James Mond ,  Adam S. Grossman

IPC分类号： C07K16/12 ,  C07K16/06 ,  A61K35/16 ,  A61K9/00

CPC分类号： C07K16/1275 ,  A61K9/0019 ,  A61K35/16 ,  C07K16/06 ,  C07K16/065 ,  C07K2317/10 ,  C07K2317/21

摘要： The present invention relates to compositions and methods for the treatment of infection caused by Streptococcus pneumonia. In particular, the invention provides human hyperimmune globulin and compositions thereof for preventing or treating pneumococcal infection. The invention provides methods of producing hyperimmune globulin containing high titers of opsonophagocytic anti-pneumococcal antibodies, compositions containing same, and methods of using the compositions for the prevention and treatment of pneumococcal infection. The invention further provides methods of preventing or treating pneumococcal infection (e.g., upper respiratory infections (e.g., bronchitis, otitis, sinusitis, etc.)) in immunocompromised subjects via administration of hyperimmune globulin compositions of the invention (e.g., containing a high titer of opsonophagocytic anti-pneumococcal antibodies) to immunocompromised subjects.

公开(公告)号：US20180258159A1

公开(公告)日：2018-09-13

申请号：US15978692

申请日：2018-05-14

申请人： ADMA Biologics, Inc.

发明人： Adam S. Grossman ,  James Mond ,  Jerrold B. Grossman ,  Dov A. Goldstein

IPC分类号： C07K16/06 ,  C07K16/08 ,  C07K16/10 ,  C07K16/12 ,  A61K45/06 ,  G01N33/68

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

公开(公告)号：US20180086818A1

公开(公告)日：2018-03-29

申请号：US15811486

申请日：2017-11-13

申请人： ADMA Biologics, Inc.

发明人： Adam S. Grossman ,  James Mond ,  Jerrold B. Grossman ,  Dov A. Goldstein

IPC分类号： C07K16/06 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  C07K16/08 ,  C07K16/10 ,  C07K16/12 ,  G01N33/68

CPC分类号： C07K16/06 ,  A61K39/155 ,  A61K39/39516 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/507 ,  C07K16/08 ,  C07K16/10 ,  C07K16/1009 ,  C07K16/1027 ,  C07K16/1203 ,  C07K16/1232 ,  C07K16/1242 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1282 ,  C07K16/1285 ,  C07K16/1289 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/76 ,  G01N33/6854 ,  Y02A50/466 ,  Y02A50/469

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

公开(公告)号：US20160114037A1

公开(公告)日：2016-04-28

申请号：US14592727

申请日：2015-01-08

申请人： ADMA Biologics, Inc.

发明人： Adam S. Grossman ,  James Mond ,  Jerrold B. Grossman ,  Dov A. Goldstein

IPC分类号： A61K39/42 ,  C07K16/10 ,  G01N33/68 ,  A61K45/06

CPC分类号： C07K16/06 ,  A61K39/155 ,  A61K39/39516 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/507 ,  C07K16/08 ,  C07K16/10 ,  C07K16/1009 ,  C07K16/1027 ,  C07K16/1203 ,  C07K16/1232 ,  C07K16/1242 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1282 ,  C07K16/1285 ,  C07K16/1289 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/76 ,  G01N33/6854 ,  Y02A50/466 ,  Y02A50/469

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

摘要翻译： 本发明涉及用于治疗免疫缺陷（例如原发性免疫缺陷病）的组合物和方法。 特别地，本发明提供了包含对多种呼吸道病原体特异的选择性抗体滴度的人血浆免疫球蛋白组合物，鉴定用于组合物中的人供体和供体样品的方法，制备组合物的方法和使用组合物的方法（例如， ，用于预防性给药和/或治疗性治疗（例如，被动免疫（例如，免疫预防）））。