公开(公告)号：US20230383236A1

公开(公告)日：2023-11-30

申请号：US18295384

申请日：2023-04-04

Applicant: ADVA Biotechnology Ltd.

Inventor： Ohad KARNIELI ,  Noam BERCOVICH

IPC: C12M1/36 ,  C12M1/34 ,  C12M1/00 ,  C12Q1/00 ,  C12Q1/02

CPC classification number: C12M41/48 ,  C12M41/36 ,  C12M41/44 ,  C12M29/10 ,  C12Q1/02 ,  C12M41/34 ,  C12M41/32 ,  C12M41/26 ,  C12Q1/00 ,  C12M41/12

Abstract: Bioreactor systems and controlled operation of bioreactor systems are disclosed herein. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems. The controlled operation of the parameters includes, for example, cell concentration; a rate of flow; a volume; a pH; a temperature; a level of oxygen; a level of carbon dioxide; a level of bicarbonate ion; nutrient compound; and any combination thereof.

公开(公告)号：US20220195375A1

公开(公告)日：2022-06-23

申请号：US17688115

申请日：2022-03-07

Applicant: ADVA Biotechnology Ltd.

Inventor： Ohad KARNIELI ,  Noam BERCOVICH

IPC: C12M1/36 ,  C12M1/34 ,  C12M1/00

Abstract: Bioreactor systems and controlled operation of bioreactor systems are disclosed herein. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems. The controlled operation of the parameters includes, for example, cell concentration; a rate of flow; a volume; a pH; a temperature; a level of oxygen; a level of carbon dioxide; a level of bicarbonate ion; nutrient compound; and any combination thereof.

公开(公告)号：US20210222114A1

公开(公告)日：2021-07-22

申请号：US17153062

申请日：2021-01-20

Applicant: ADVA Biotechnology Ltd.

Inventor： Ohad KARNIELI ,  Noam BERCOVICH

IPC: C12M1/36 ,  C12M1/34 ,  C12M1/00

Abstract: Bioreactor systems and controlled operation of bioreactor systems are disclosed herein. The bioreactor systems can include at least one bioreactor chamber, at least one reservoir, a plurality of sensors, and a fluid circuit. The operational methods disclosed herein are directed towards growing cells or tissue while measuring various parameters, and a controlled operation of the various parameters during the operation of the bioreactor systems. The controlled operation of the parameters includes, for example, cell concentration; a rate of flow; a volume; a pH; a temperature; a level of oxygen; a level of carbon dioxide; a level of bicarbonate ion; nutrient compound; and any combination thereof.