公开(公告)号：US20170002331A1

公开(公告)日：2017-01-05

申请号：US15101586

申请日：2014-12-02

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Boon Hwa Andre Choo ,  Jiyun Zheng

IPC: C12N5/16 ,  C12N5/00 ,  C07K16/18

CPC classification number: C12N5/163 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/73 ,  C12N5/0081

Abstract: An antibody that binds a glycosylated protein is disclosed, wherein the glycosylation comprises the glycan motif Fucα1-2Galβ1-3GlcNAc1-3Galβ1 or Fucα1-2Galβ1-3GlcNAc. Antibodies that are cytotoxic against undifferentiated pluripotent cells are also disclosed.

Abstract translation: 公开了结合糖基化蛋白质的抗体，其中糖基化包括聚糖基序Fucα1-2Galβ1-3GlcNAc1-3Galβ1或Fucα1-2Galβ1-3GlcNAc。 还公开了对未分化多能细胞具有细胞毒性的抗体。

公开(公告)号：US11512292B2

公开(公告)日：2022-11-29

申请号：US16545736

申请日：2019-08-20

Applicant: Agency for Science, Technology and Research

Inventor： Boon Hwa Andre Choo ,  Jiyun Zheng

IPC: C07K16/18 ,  C12N5/16 ,  C07K16/44 ,  C12N5/00

Abstract: An antibody that binds a glycosylated protein is disclosed, wherein the glycosylation comprises the glycan motif Fucα1-2Galβ1-3GlcNAcβ1-3Galβ1 or Fucα1-2Galβ1-3GlcNAc. Antibodies that are cytotoxic against undifferentiated pluripotent cells are also disclosed.

公开(公告)号：US10428312B2

公开(公告)日：2019-10-01

申请号：US15101586

申请日：2014-12-02

Applicant: Agency for Science, Technology and Research

Inventor： Boon Hwa Andre Choo ,  Jiyun Zheng

IPC: C07K16/00 ,  C12N5/16 ,  C07K16/18 ,  C07K16/44 ,  C12N5/00

Abstract: An antibody that binds a glycosylated protein is disclosed, wherein the glycosylation comprises the glycan motif Fucα1-2Galβ1-3GlcNAc1-3Galβ1 or Fucα1-2Galβ1-3GlcNAc. Antibodies that are cytotoxic against undifferentiated pluripotent cells are also disclosed.